Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

The Hallmarks of Cancer

2000 • 27,569 citations

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 6,495 citations

Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

1994 • 2,375 citations

STATs in oncogenesis

2000 • 1,723 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

Chronic Myeloid Leukemia — Advances in Biology and New Approaches to Treatment

2003 • 962 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

B lymphocyte-specific, Cre-mediated mutagenesis in mice

1997 • 696 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo

2000 • 594 citations

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

2001 • 573 citations

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

2003 • 441 citations

Essential role of STAT3 for embryonic stem cell pluripotency

1999 • 404 citations

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

2002 • 389 citations

Expression of ALK1 and p80 in Inflammatory Myofibroblastic Tumor and Its Mesenchymal Mimics: A Study of 135 Cases

2002 • 371 citations

Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL

2000 • 362 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

1999 • 341 citations

A New Subtype of Large B-Cell Lymphoma Expressing the ALK Kinase and Lacking the 2; 5 Translocation

1997 • 334 citations

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

2004 • 317 citations

Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2

2000 • 310 citations

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

2004 • 305 citations

Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

2001 • 300 citations

Nucleophosmin-Anaplastic Lymphoma Kinase of Large-Cell Anaplastic Lymphoma Is a Constitutively Active Tyrosine Kinase That Utilizes Phospholipase C-γ To Mediate Its Mitogenicity

1998 • 281 citations

Translocations involving anaplastic lymphoma kinase (ALK)

2001 • 279 citations

Retrovirus-Mediated Gene Transfer of NPM-ALK Causes Lymphoid Malignancy in Mice

1997 • 278 citations

NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors

2003 • 251 citations

STAT3 Is a Negative Regulator of Granulopoiesis but Is Not Required for G-CSF-Dependent Differentiation

2002 • 244 citations

Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice

2002 • 216 citations

Hepatic and glucagon-like peptide-1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

2004 • 205 citations

Stat5a/b contribute to interleukin 7–induced B-cell precursor expansion, but abl- andbcr/abl-induced transformation are independent of Stat5

2000 • 196 citations

Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db Mice

2004 • 193 citations

Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas

2000 • 188 citations

ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma

2003 • 185 citations

STAT proteins as novel targets for cancer therapy

1999 • 180 citations

Stat5a/b contribute to interleukin 7–induced B-cell precursor expansion, but abl- andbcr/abl-induced transformation are independent of Stat5

2000 • 171 citations

Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells

2002 • 125 citations

Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells.

2001 • 113 citations

Malignant Transformation but not Normal Cell Growth Depends on Signal Transducer and Activator of Transcription 3

2005 • 111 citations

CD30 Overexpression Enhances Negative Selection in the Thymus and Mediates Programmed Cell Death Via a Bcl-2-Sensitive Pathway

1999 • 109 citations

Differential Regulation of Constitutive Major Histocompatibility Complex Class I Expression in T and B Lymphocytes

1999 • 71 citations