Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation

Antibodies, a laboratory manual

1989 • 12,929 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

1994 • 450 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

1985 • 408 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)

1987 • 357 citations

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

1994 • 334 citations

A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells

1990 • 313 citations

Involvement of pp60c-src with two major signaling pathways in human breast cancer.

1994 • 273 citations

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.

1992 • 271 citations

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1995 • 261 citations

The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer.

1994 • 246 citations

PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine

1995 • 245 citations

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.

1994 • 233 citations

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

1988 • 227 citations

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.

1994 • 205 citations

Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2.

1994 • 204 citations

Prognostic factors in early breast carcinoma

1994 • 199 citations

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

1994 • 198 citations

Novel Activating Mutations in the neu Proto-oncogene Involved in Induction of Mammary Tumors

1994 • 188 citations

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

1992 • 186 citations

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

1994 • 182 citations

Requirement for the Adapter Protein GRB2 in EGF Receptor Endocytosis

1996 • 178 citations

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

1995 • 174 citations

Tyrosine Phosphorylation Sites at Amino Acids 239 and 240 of Shc Are Involved in Epidermal Growth Factor-Induced Mitogenic Signaling That Is Distinct from Ras/Mitogen-Activated Protein Kinase Activation

1997 • 156 citations

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

1994 • 144 citations

The Phosphotyrosine Interaction Domain of Shc Binds an LXNPXY Motif on the Epidermal Growth Factor Receptor

1995 • 137 citations

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

1992 • 136 citations

The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain.

1991 • 128 citations

Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.

1994 • 128 citations

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.

1994 • 113 citations

Shc products are substrates of erbB-2 kinase.

1993 • 108 citations

Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor.

1995 • 104 citations

Cellular ras Activity Is Required for Passage through Multiple Points of the G₀/G₁ Phase in BALB/c 3T3 Cells

1994 • 98 citations

Binding of NCK to SOS and Activation of ras-Dependent Gene Expression

1995 • 94 citations

The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency.

1991 • 86 citations

Identification of autophosphorylation sites of HER2/neu.

1990 • 76 citations

Epidermal growth factor receptor status of histological sub-types of breast cancer

1988 • 72 citations

Affinity, Specificity, and Kinetics of the Interaction of the SHC Phosphotyrosine Binding Domain with Asparagine-X-X-Phosphotyrosine Motifs of Growth Factor Receptors

1996 • 68 citations

The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.

1990 • 66 citations

Tyrosine phosphatase inhibition permits analysis of signal transduction complexes in p185HER2/neu-overexpressing human tumor cells.

1992 • 58 citations

Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase.

1995 • 58 citations

The role of autophosphorylation in modulation of erbB-2 transforming function.

1990 • 53 citations

Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK.

1996 • 44 citations

Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation.

1996 • 43 citations

erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling.

1992 • 19 citations

Carboxyl-terminal deletion and point mutations decrease the transforming potential of the activated rat neu oncogene product.

1992 • 11 citations