The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1997 • 1,554 citations

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

1996 • 1,393 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

A Hierarchical Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor

1996 • 1,021 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer

1994 • 981 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.

1992 • 855 citations

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1992 • 853 citations

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.

1996 • 772 citations

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.

1990 • 763 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

1994 • 692 citations

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.

1996 • 675 citations

p185^HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

1989 • 672 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

1994 • 520 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor.

1989 • 479 citations

Neuregulins and Their Receptors: A Versatile Signaling Module in Organogenesis and Oncogenesis

1997 • 471 citations

HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma.

1992 • 466 citations

All ErbB Receptors Other Than the Epidermal Growth Factor Receptor Are Endocytosis Impaired

1996 • 452 citations

p185neu expression in human lung adenocarcinomas predicts shortened survival.

1990 • 440 citations

Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells.

1994 • 439 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness.

1993 • 413 citations

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.

1995 • 407 citations

Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

1997 • 390 citations

The Cellular Response to Neuregulins Is Governed by Complex Interactions of the erbB Receptor Family

1995 • 364 citations

Two EGF molecules contribute additively to stabilization of the EGFR dimer

1997 • 363 citations

Intermolecular association of the p185 protein and EGF receptor modulates EGF receptor function

1990 • 362 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

Identification of c-erbB-3 binding sites for phosphatidylinositol 3′-kinase and SHC using an EGF receptor/c-erbB-3 chimera.

1994 • 354 citations

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

1997 • 348 citations

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.

1986 • 341 citations

Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts

1989 • 316 citations

Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities

1996 • 311 citations

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.

1995 • 304 citations

Single-Chain Antibody-Mediated Intracellular Retention of ErbB-2 Impairs Neu Differentiation Factor and Epidermal Growth Factor Signaling

1995 • 300 citations

Ligands for ErbB-family receptors encoded by a neuregulin-like gene

1997 • 288 citations

Direct Interaction of a Ligand for the erb B2 Oncogene Product with the EGF Receptor and p185 ^{erb B2}

1990 • 279 citations

ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.

1994 • 273 citations

Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.

1995 • 273 citations

Prognostic significance of her‐2/neu expression in breast cancer and its relationship to other prognostic factors

1991 • 262 citations

Tyrphostins. II. Heterocyclic and .alpha.-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases

1991 • 260 citations

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

1990 • 246 citations

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships.

1993 • 237 citations

Molecular Aspects of Mesenchymal-Epithelial Interactions

1993 • 232 citations

Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.

1994 • 231 citations

Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.

1996 • 229 citations

Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.

1996 • 228 citations

Bivalence of EGF-like ligands drives the ErbB signaling network

1997 • 226 citations

Transformation of NIH 3T3 Cells by HER3 or HER4 Receptors Requires the Presence of HER1 or HER2

1996 • 208 citations

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

1994 • 198 citations

The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast.

1992 • 196 citations

Prognostic value of c-erbB-2 protein expression in human lung adenocarcinoma and squamous cell carcinoma

1991 • 185 citations

Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu.

1995 • 184 citations

A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors

1997 • 178 citations

Selective Cleavage of the Heregulin Receptor ErbB-4 by Protein Kinase C Activation

1996 • 176 citations

Vulval development in Caenorhabditis elegans

1997 • 175 citations

Intracellular expression of single chain antibodies reverts ErbB-2 transformation.

1994 • 156 citations

Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins.

1996 • 153 citations

Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake.

1995 • 149 citations

Neu Differentiation Factor/Neuregulin Isoforms Activate Distinct Receptor Combinations

1996 • 142 citations

Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.

1995 • 138 citations

There Must Be 50 Ways to Rule the Signal: The Case of the Drosophila EGF Receptor

1997 • 134 citations

Overexpression of the c-erbB-2 oncoprotein: Why does this occur more frequently in ductal carcinoma in situ than in invasive mammary carcinoma and is this of prognostic significance?

1992 • 131 citations

Evidence for a role of EGF receptor in the progression of human lung carcinoma.

1993 • 131 citations

An Immunological Approach Reveals Biological Differences between the Two NDF/Heregulin Receptors, ErbB-3 and ErbB-4

1996 • 130 citations

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation

1993 • 129 citations

The Relationship between Human Epidermal Growth-like Factor Receptor Expression and Cellular Transformation in NIH3T3 Cells

1996 • 124 citations

Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.

1991 • 117 citations

Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses.

1992 • 117 citations

The expression of EGF receptors, EGF-like factors and c-myc in ovarian and cervical carcinomas and their potential clinical significance.

1989 • 115 citations

Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.

1989 • 114 citations

Characterization of a Neuregulin-Related Gene, Don-1, That Is Highly Expressed in Restricted Regions of the Cerebellum and Hippocampus

1997 • 114 citations

The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired.

1993 • 107 citations

Prognostic significance of transforming growth factor-α in human esophageal carcinoma implication for the autocrine proliferation

1993 • 99 citations

Ligand and p185c-neu density govern receptorinteractions and tyrosine kinase activation.

1994 • 92 citations

The Structural Basis for the Specificity of Epidermal Growth Factor and Heregulin Binding

1995 • 91 citations

Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659).

1990 • 91 citations

Linkage of tyrosine kinase activity with transforming ability of the p185neu oncoprotein.

1989 • 89 citations

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.

1991 • 87 citations

Binding of Neu Differentiation Factor with the Extracellular Domain of Her2 and Her3

1995 • 76 citations

Biochemical analysis of the ligand for the neu oncogenic receptor

1991 • 73 citations

Response to mitoxantrone in advanced breast cancer: correlation with expression of c-erbB-2 protein and glutathione S-transferases

1992 • 66 citations

NDF/heregulin stimulates the phosphorylation of Her3/erbB3

1994 • 65 citations

Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds.

1995 • 61 citations

Neu Differentiation Factor Inhibits EGF Binding

1995 • 61 citations

Targeted inhibition of tumor‐cell growth by recombinant heregulin‐toxin fusion proteins

1995 • 49 citations

An oncogenic point mutation confers high affinity ligand binding to the neu receptor. Implications for the generation of site heterogeneity.

1992 • 48 citations

Identification of Residues of the Epidermal Growth Factor Receptor Proximal to Residue 45 of Bound Epidermal Growth Factor

1996 • 43 citations

Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock.

1989 • 41 citations

Topographic Analysis of Human Epidermal Growth Factor by Monospecific Antibodies and Synthetic Peptides

1989 • 36 citations

Molecular and clinical aspects of the Neu/ErbB-2 receptor tyrosine kinase

1994 • 28 citations

HER4 Expression Correlates with Cytotoxicity Directed by a Heregulin-Toxin Fusion Protein

1995 • 25 citations

Tissue and tumor expression of a cell surface glycoprotein complex containing an integral membrane glycoprotein activator of p185neu.

1994 • 24 citations

Cumulative effect of double-site mutations of human epidermal growth factor on receptor binding.

1993 • 23 citations

The ErbB 2 Oncogene and Chemotherapy: a Mini-Review

1997 • 19 citations

Multidomain binding of transforming growth factor .alpha. to the epidermal growth factor receptor

1992 • 18 citations

Type-1 growth factor receptors in pancreatic and gastrointestinal neoplasia

1995 • 4 citations