Prognostic factors in early breast carcinoma

Regression Models and Life-Tables

1992 • 27,454 citations

Regression Models and Life-Tables

1972 • 27,145 citations

Classification and Regression Trees.

1986 • 21,574 citations

Classification and regression trees

1985 • 11,138 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases

1989 • 2,245 citations

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

1992 • 2,084 citations

p53 function and dysfunction

1992 • 1,918 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells

1984 • 1,416 citations

The Nottingham prognostic index in primary breast cancer

1992 • 1,051 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

Treatment of Early-Stage Breast Cancer

1991 • 763 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Predictive value of statistical models

1990 • 590 citations

Prediction of Relapse or Survival in Patients with Node-Negative Breast Cancer by DNA Flow Cytometry

1989 • 571 citations

The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study.

1988 • 538 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS AND OESTROGEN RECEPTORS IN HUMAN BREAST CANCER

1985 • 496 citations

Cancer of the breast: Size of neoplasm and prognosis

1969 • 491 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

Vasculae Reactions of Normal and Malignant Tissues in Vivo. I. Vascular Reactions of Mice to Wounds and to Normal and Neoplastic Transplants

1945 • 466 citations

Patterns of relapse and survival following radical mastectomy.Analysis of 716 consecutive patients

1978 • 465 citations

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

1982 • 448 citations

Relative worth of estrogen or progesterone receptor and pathologic characteristics of differentiation as indicators of prognosis in node negative breast cancer patients: findings from National Surgical Adjuvant Breast and Bowel Project Protocol B-06.

1988 • 415 citations

A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma.

1989 • 385 citations

Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer

1993 • 367 citations

Heat Shock Protein hsp70 in Patients With Axillary Lymph Node-Negative Breast Cancer: Prognostic Implications

1993 • 361 citations

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

1992 • 349 citations

Indicators of Prognosis in Node-Negative Breast Cancer

1990 • 348 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot.

1992 • 283 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

Association of DNA index and S-phase fraction with prognosis of nodes positive early breast cancer.

1987 • 263 citations

The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

1989 • 260 citations

Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.

1989 • 250 citations

Tumor Behavior in Isolated Perfused Organs

1966 • 247 citations

Response of human breast cancer cells to heat shock and chemotherapeutic drugs.

1992 • 247 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

A new family of growth factor‐like peptides ‘Trefoil’ disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins)

1989 • 236 citations

Clinical Relevance of the Urokinase-Type and Tissue-Type Plasminogen Activators and of Their Type 1 Inhibitor in Breast Cancer

1991 • 236 citations

Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.

1989 • 228 citations

Improving the prognostic value of DNA flow cytometry in breast cancer by combining DNA index and S-phase fraction: A proposed classification of DNA histograms in breast cancer

1988 • 226 citations

Immunohistochemical detection of p53 protein in mammary carcinoma: An important new independent indicator of prognosis?

1993 • 225 citations

EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTORS ASSOCIATED WITH LACK OF RESPONSE TO ENDOCRINE THERAPY IN RECURRENT BREAST CANCER

1989 • 224 citations

DNA ploidy and survival in breast cancer patients

1987 • 223 citations

Lead in dringking water.

1967 • 219 citations

Implications of the NIH Consensus Development Conference on the Treatment of Early-Stage Breast Cancer

1991 • 214 citations

Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas.

1991 • 200 citations

Consensus review of the clinical utility of dna cytometry in carcinoma of the breast

1993 • 196 citations

Immunocytochemical Analysis of Estrogen Receptors in Human Breast Carcinomas

1990 • 190 citations

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.

1990 • 181 citations

Relationship of prediagnostic serum levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate to the risk of developing premenopausal breast cancer.

1992 • 181 citations

Prognostic indicators including DNA histogram type, receptor content, and staging related to human breast cancer patient survival.

1984 • 175 citations

Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer

1991 • 174 citations

Epidermal growth factor receptor (EGFr); results of a 6 year follow-up study in operable breast cancer with emphasis on the node negative subgroup

1991 • 171 citations

Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival

1990 • 171 citations

Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods.

1989 • 168 citations

Novel growth regulatory factors and tumour angiogenesis

1991 • 162 citations

p53 protein expression in mammary ductal carcinoma in situ: Relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein

1993 • 157 citations

Correlation of Pretreatment Proliferative Activity of Breast Cancer With the Response to Cytotoxic Chemotherapy

1989 • 156 citations

DNA flow cytometry in solid tumors: practical aspects and clinical applications.

1989 • 156 citations

Prognostic significance of peritumoral lymphatic and blood vessel invasion in node-negative carcinoma of the breast.

1990 • 154 citations

Stress Response Protein (srp-27) Determination in Primary Human Breast Carcinomas: Clinical, Histologic, and Prognostic Correlations

1991 • 153 citations

Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study

1990 • 150 citations

Prognostic value of steroid hormone receptors: multivariate analysis of systemically untreated patients with node negative primary breast cancer.

1987 • 150 citations

Relation between p53 overexpression and established prognostic factors in breast cancer.

1991 • 149 citations

Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells.

1987 • 147 citations

A practical application of neural network analysis for predicting outcome of individual breast cancer patients

1992 • 146 citations

Progesterone and estrogen receptors as prognostic variables in breast cancer.

1983 • 143 citations

Angiogenic Activity as a Marker of Neoplastic and Preneoplastic Lesions of the Human Bladder

1980 • 142 citations

MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: A permissive role of cathepsin D

1991 • 142 citations

Cathepsin D: A protease involved in breast cancer metastasis

1990 • 140 citations

Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer.

1991 • 140 citations

Correlation of cell-cycle kinetics, hormone receptors, histopathology, and nodal status in human breast cancer

1984 • 135 citations

Node-negative breast cancer: prognostic subgroups defined by tumor size and flow cytometry.

1990 • 126 citations

Multiparametric Prognostic Evaluation of Biological Factors in Primary Breast Cancer

1992 • 125 citations

Estrogens and growth factors induce the mRNA of the 52K-pro-cathepsin-D secreted by breast cancer cells

1988 • 123 citations

pS2 expression and response to hormonal therapy in patients with advanced breast cancer.

1991 • 123 citations

Interactions of Cathepsin-D and Insulin-Like Growth Factor-II (IGF-II) on the IGF-II/Mannose-6-Phosphate Receptor in Human Breast CancerCells and Possible Consequences on Mitogenic Activity of IGF-II

1990 • 119 citations

Cathepsin D expression detected by immunohistochemistry has independent prognostic value in axillary node-negative breast cancer.

1993 • 118 citations

Factors predicting treatment responsiveness and prognosis in node-negative breast cancer. The International (Ludwig) Breast Cancer Study Group.

1992 • 116 citations

Expression of epidermal growth factor receptor in breast carcinoma.

1990 • 115 citations

p53 Mutations: Gains or losses?

1991 • 111 citations

Prognostic significance of dna‐ploidy in a series of 690 primary breast cancer patients

1990 • 108 citations

The relation of flow cytometry to clinical and biologic characteristics in women with node negative primary breast cancer

1989 • 105 citations

Significance of estrogen and progesterone receptors, disease-free interval, and site of first metastasis on survival of breast cancer patients

1985 • 105 citations

Human breast cancer: prognostic significance of the c-erbB-2 oncoprotein compared with epidermal growth factor receptor, DNA ploidy, and conventional pathologic features.

1992 • 103 citations

Epidermal growth factor receptor expression as a prognostic indicator in breast cancer

1991 • 100 citations

Epidermal growth factor receptor and other oncogenes as prognostic markers.

1992 • 98 citations

The 52-kDa estrogen-induced protein secreted by MCF7 cells is a lysosomal acidic protease

1986 • 98 citations

DNA flow cytometric analysis of primary operable breast cancer. Relation of ploidy and S-Phase fraction to outcome of patients in NSABP B-04

1991 • 97 citations

Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays.

1992 • 93 citations

A plain man's guide to the proportional hazards model.

1982 • 91 citations

Prognostic value of estrogen and progesterone receptors in operable breast cancer: Results of a univariate and multivariate analysis

1988 • 91 citations

Cloning and Sequencing of the 52K Cathepsin D Complementary Deoxyribonucleic Acid of MCF7 Breast Cancer Cells and Mapping on Chromosome 11

1988 • 91 citations

Prognostic significance of flow cytometric DNA analysis in node-negative breast cancer patients

1990 • 84 citations

Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer

1989 • 79 citations

A prospective study of the prognostic value of cathepsin D levels in breast cancer cytosol

1993 • 74 citations

Prognostic value of epidermal growth factor receptor in node-positive breast cancer

1989 • 73 citations

Abnormal estrogen receptor in clinical breast cancer

1992 • 69 citations

The prognostic value of immunohistochemical estrogen receptor analysis in paraffin-embedded and frozen sections versus that of steroid-binding assays

1990 • 69 citations

Review: Steroid Receptors, Cellular Kinetics, and Lymph Node Status as Prognostic Factors in Breast Cancer

1988 • 68 citations

Immunocytochemical detection of progesterone receptor in breast cancer with monoclonal antibody. Relation to biochemical assay, disease-free survival, and clinical endocrine response

1988 • 67 citations

Abnormalp53 immunoreactivity and prognosis in node-negative breast carcinomas with long-term follow-up

1992 • 66 citations

Prognostic significance of cathepsin-D in patients with breast cancer

1993 • 63 citations

Prognostic value of pS2 protein and receptors for epidermal growth factor (EGF-R), Insulin-like growth factor-1 (IGF-1-R) and somatostatin (SS-R) in patients with breast and ovarian cancer

1990 • 62 citations

Sequential cytopunctures during preoperative chemotherapy for primary breast carcinoma. Cytomorphologic changes, initial tumor ploidy, and tumor regression

1989 • 62 citations

Flow Cytometric DNA Index and S-Phase Fraction in Breast Cancer in Relation to Other Prognostic Variables and to Clinical Outcome

1992 • 61 citations

The Importance of DNA Flow Cytometry in Node-Negative Breast Cancer

1990 • 60 citations

Sequential cytopunctures during preoperative chemotherapy for primary breast carcinoma. II. DNA flow cytometry changes during chemotherapy, tumor regression, and short-term follow-up

1992 • 59 citations

Strain specific sensitivity to diethylnitrosamine-induced carcinogenesis is maintained in hepatocytes of C3H/HeN in equilibrium with C57BL/6N chimeric mice.

1991 • 58 citations

Human breast cancer: identification of populations with a high risk of early relapse in relation to both oestrogen receptor status and c-erbB-2 overexpression

1990 • 56 citations

Prognostic value of total cathepsin D in breast tumors

1991 • 55 citations

Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer

1993 • 54 citations

Cathepsin D concentration in breast cancer cytosols: correlation with biochemical, histological, and clinical findings

1991 • 54 citations

Epidermal growth factor receptors and prognosis in primary breast cancer

1990 • 53 citations

DNA content and genetic evolution of human colorectal adenocarcinoma. A study by flow cytometry and cytogenetic analysis

1988 • 52 citations

Confirmation of a prognostic index for patients with metastatic breast cancer treated by endocrine therapy

1992 • 51 citations

Dna content measurement can be obtained using archival material for dna flow cytometry a comparison with cytogenetic analysis in 56 pediatric solid tumors

1993 • 48 citations

Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers

1991 • 47 citations

Differential regulation of cathepsin D by sex steroids in mammary cancer and uterine cells

1989 • 46 citations

Clinical breast cancer, new developments in selection and endocrine treatment of patients

1992 • 46 citations

Growth factor expression in Breast tissue

1990 • 43 citations

Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance

1991 • 41 citations

Immunochemical analysis of the p53 oncoprotein in matched primary and metastatic human tumours

1993 • 39 citations

Nuclear characteristics as indicators of prognosis in node negative breast cancer patients

1989 • 38 citations

Two-site immunoenzymometric assay for the 52-kDa cathepsin D in cytosols of breast cancer tissues.

1989 • 37 citations

Complete Primary Structure of the Human Estrogen-Responsive Gene (pS2) Product1

1990 • 36 citations

The long term prognostic significance of oestrogen receptor analysis in early carcinoma of the breast

1991 • 35 citations

A comparison of all-subset Cox and accelerated failure time models with Cox step-wise regression for node-positive breast cancer

1992 • 32 citations

[Cathepsin D: an independent prognostic factor in cancer of the breast].

1990 • 32 citations

Tissue‐specific markers in flow cytometry of urological cancers. III. Comparing chromosomal and flow cytometric dna analysis of bladder tumors

1987 • 28 citations

Prognostic relevance of pS2 status in association with steroid receptor status and proliferative activity in node-negative breast cancer

1992 • 27 citations

Proportional hazards and recursive partitioning and amalgamation analyses of the southwest oncology group node-positive adjuvant CMFVP breast cancer data base: a pilot study

1992 • 25 citations

Stimulatory and inhibitory growth factors and breast cancer

1990 • 23 citations

Transforming growth factor alpha in human mammary carcinomas and their metastases.

1989 • 20 citations

Pregnancy-associated plasma protein A and extensive necrosis. Clinically significant predictors of early recurrence in stage I estrogen receptor-negative breast carcinoma.

1985 • 20 citations

Regulation of tumor-host interactions in breast cancer

1992 • 18 citations

Response to second-line hormone treatment for advanced breast cancer. Predictive value of ploidy determination

1990 • 17 citations

A model of chemotherapy in node-negative breast cancer.

1992 • 16 citations

RECPAM analysis of prognostic factors in patients with Stage III breast cancer

1990 • 16 citations

Prognostic value of epidermal growth factor receptor in a series of 303 breast cancers

1992 • 16 citations

The importance of normal and abnormal oestrogen receptor in breast cancer.

1992 • 13 citations

Are DNA Flow Cytometry Measurements Providing Useful Information in the Management of the Node-Negative Breast Cancer Patient?

1992 • 13 citations

Regulation of Transformation and the Cell Cycle by p53

1991 • 11 citations

Comparison of classic and quantitative prognostic factors in hormone receptor-positive and hormone receptor-negative female breast cancer

1993 • 8 citations

Epidermal Growth Factor Receptors and Prognosis in Breast Cancer

1990 • 4 citations

An antiserum to tumour angiogenesis factor: therapeutic approach to solid tumours.

1989 • 4 citations

An antiserum to tumour angiogenesis factor: therapeutic approach to solid tumours.

1989 • 3 citations

The use of dna flow cytometry to characterize breast cancer cells affected by presurgical neoadjuvant chemotherapy

1992 • 1 citations

Deleted Work

1955 • 0 citations