An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Growth Factors and Cancer

1991 • 2,044 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1981 • 795 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues.

1990 • 640 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

1985 • 513 citations

HER-2/neu amplification predicts poor survival in node-positive breast cancer.

1990 • 456 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

p185neu expression in human lung adenocarcinomas predicts shortened survival.

1990 • 440 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.

1986 • 370 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.

1992 • 354 citations

Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer.

1991 • 331 citations

Transgenic Models of Tumor Development

1991 • 289 citations

The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region.

1987 • 275 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

Expression of the c‐erbB‐2 protein in normal and transformed cells

1987 • 197 citations

The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates.

1990 • 194 citations

Stage- and tissue-specific expression of the neu oncogene in rat development.

1987 • 163 citations

Amplification and overexpression of the erbB-2 gene in human tumors: its involvement in tumor development, significance as a prognostic factor, and potential as a target for cancer therapy.

1993 • 131 citations

Epidermal Growth Factor Receptor, but Not c-erbB-2, Activation Prevents Lactogenic Hormone Induction of the β-Casein Gene in Mouse Mammary Epithelial Cells

1990 • 129 citations

Cell cycle regulation of glucocorticoid receptor function.

1992 • 124 citations

A mammary cell-specific enhancer in mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for CTF/NFI and a novel transcription factor, mammary cell-activating factor.

1992 • 117 citations

Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation.

1991 • 115 citations

The v-mos and H-ras oncogene expression represses glucocorticoid hormone-dependent transcription from the mouse mammary tumor virus LTR.

1986 • 115 citations

Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active.

1990 • 105 citations

The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice

1987 • 100 citations

Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues.

1989 • 99 citations

Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice.

1988 • 96 citations

Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659).

1990 • 91 citations

Two Regions of the Mouse Mammary Tumor Virus Long Terminal Repeat Regulate the Activity of Its Promoter in Mammary Cell Lines

1991 • 88 citations

Endogenous mouse mammary tumor virus is expressed in several organs in addition to the lactating mammary gland

1988 • 75 citations

Multiple regulatory domains in the mouse mammary tumor virus long terminal repeat revealed by analysis of fusion genes in transgenic mice.

1988 • 70 citations

Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen.

1987 • 69 citations

The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.

1990 • 66 citations

C-erbB-2 gene product, a membrane protein commonly expressed on human fetal epithelial cells.

1989 • 64 citations

Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice.

1990 • 60 citations

The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.

1991 • 52 citations

Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene.

1990 • 47 citations

Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice.

1990 • 45 citations

A Mammary Cell-Specific Enhancer in Mouse Mammary Tumor Virus DNA Is Composed of Multiple Regulatory Elements Including Binding Sites for CTF/NFI and a Novel Transcription Factor, Mammary Cell-Activating Factor

1992 • 41 citations

Identification of a novel mammary cell line-specific enhancer element in the long terminal repeat of mouse mammary tumor virus, which interacts with its hormone-responsive element

1991 • 36 citations

Requirement for the Simian Virus 40 Small Tumor Antigen in Tumorigenesis in Transgenic Mice

1988 • 34 citations

Transgenic Mice Carrying the Mouse Mammary Tumor Virus ras Fusion Gene: Distinct Effects in Various Tissues

1989 • 30 citations

Negative Regulation in Correct Tissue-Specific Expression of Mouse Mammary Tumor Virus in Transgenic Mice

1990 • 28 citations

p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2.

1990 • 26 citations

The Carboxy-Terminal Domains of erbB-2 and Epidermal Growth Factor Receptor Exert Different Regulatory Effects on Intrinsic Receptor Tyrosine Kinase Function and Transforming Activity

1990 • 18 citations

The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gpl85^erbB-2 Determine the Specificity of Signal Transduction

1991 • 9 citations