The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

A genetic map of the mouse suitable for typing intraspecific crosses.

1992 • 1,114 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

SH2 and SH3 domains

1993 • 697 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

1991 • 537 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

The C. elegans genome sequencing project: a beginning

1992 • 496 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

1993 • 395 citations

The codon preference plot: graphic analysis of protein coding sequences and prediction of gene expression

1984 • 381 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1991 • 344 citations

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.

1992 • 335 citations

Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

1987 • 335 citations

THE MOUSE IN BIOMEDICAL RESEARCH

2005 • 334 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

Molecular cloning and expression of the major protein kinase C substrate of platelets

1988 • 250 citations

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships.

1993 • 237 citations

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.

1988 • 226 citations

Cloning and expression of a widely expressed receptor tyrosine phosphatase.

1990 • 180 citations

Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis

1990 • 170 citations

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.

1992 • 170 citations

A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human.

1989 • 151 citations

HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.

1989 • 144 citations

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

1993 • 139 citations

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

1992 • 136 citations

Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity.

1993 • 115 citations

Mutations affecting embryonic cell migrations in Caenorhabditis elegans

1990 • 111 citations

Correlation of HER-2/neu Amplification With Expression and With Other Prognostic Factors in 1103 Breast Cancers

1992 • 109 citations

THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.

1993 • 88 citations

Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway.

1992 • 82 citations

Identification of autophosphorylation sites of HER2/neu.

1990 • 76 citations

Prognostic factors in breast cancer.

1992 • 76 citations

Amplification of the neu (c-erbB-2) Oncogene in Human Mammmary Tumors is Relatively Frequent and is Often Accompanied by Amplification of the Linked c-erbA Oncogene

1987 • 74 citations

c-erbB-2/c-erbA co-amplification indicative of lymph node metastasis, and c-myc amplification of high tumour grade, in human breast carcinoma

1989 • 72 citations

Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts

1993 • 71 citations

The role of autophosphorylation in modulation of erbB-2 transforming function.

1990 • 53 citations

Determination of HER-2/neu amplification and expression in tumor tissue and cultured cells using a simple, phenol free method for nucleic acid isolation.

1990 • 44 citations

Guidance of neuroblast migrations and axonal projections in Caenorhabditis elegans

1992 • 33 citations

The Pituitary Hormones Arginine Vasopressin-Neurophysin II and Oxytocin-Neurophysin I Show Close Linkage with Interleukin-1 on Mouse Chromosome 2

1993 • 24 citations