Targeted Mutagenesis of the Murine Opioid System

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Drugs of abuse: anatomy, pharmacology and function of reward pathways

1992 • 2,091 citations

Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

1979 • 1,758 citations

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

1996 • 1,652 citations

Basic Neurochemistry???Molecular, Cellular, and Medical Aspects

2006 • 1,374 citations

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

1997 • 1,362 citations

Basic Neurochemistry: Molecular, Cellular, and Medical Aspects

1989 • 1,360 citations

A potent and selective endogenous agonist for the µ-opiate receptor

1997 • 1,306 citations

Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications

1995 • 1,267 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Opioid analgesics and antagonists

1996 • 1,193 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

1992 • 1,001 citations

Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin

1982 • 928 citations

Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.

1988 • 913 citations

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

1996 • 895 citations

Molecular cloning and functional expression of a mu opioid receptor from rat brain

1994 • 805 citations

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

1996 • 779 citations

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1994 • 777 citations

Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor

1982 • 777 citations

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

1998 • 757 citations

Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety

1994 • 702 citations

Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

1997 • 702 citations

Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA

1982 • 672 citations

Primary afferent tachykinins are required to experience moderate to intense pain

1998 • 587 citations

Neurobiology of opiate abuse

1992 • 546 citations

Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches

1997 • 523 citations

Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning

1985 • 516 citations

Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia

1997 • 511 citations

C fragment of lipotropin has a high affinity for brain opiate receptors

1976 • 488 citations

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

1996 • 485 citations

Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

1997 • 481 citations

A brief history of opiates, opioid peptides, and opioid receptors.

1993 • 469 citations

Cloning and pharmacological characterization of a rat μ opioid receptor

1993 • 460 citations

Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations

1998 • 448 citations

Cloning and pharmacological characterization of a rat kappa opioid receptor.

1993 • 422 citations

Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

1997 • 413 citations

Disruption of the kappa -opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa -agonist U-50,488H and attenuates morphine withdrawal

1998 • 408 citations

Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.

1993 • 369 citations

Neural substrates of opiate withdrawal

1992 • 361 citations

Molecular biology of opioid receptors

1993 • 358 citations

Site-specific recombinases: tools for genome engineering

1993 • 353 citations

Isolation and structural organization of the human preproenkephalin B gene

1983 • 351 citations

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

1991 • 338 citations

Characterization of a common precursor to corticotropin and beta-lipotropin: cell-free synthesis of the precursor and identification of corticotropin peptides in the molecule.

1977 • 337 citations

Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis.

1996 • 323 citations

κ-Opioid receptors and analgesia

1990 • 318 citations

Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain

1979 • 305 citations

An About 50,000-Dalton Protein in Adrenal Medulla: a Common Precursor of [Met]- and [Leu]Enkephalin

1980 • 265 citations

Cellular mechanisms of opioid tolerance: studies in single brain neurons.

1987 • 260 citations

Differences between inbred strains of mice in Morris water maze performance

1988 • 237 citations

Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene

1998 • 216 citations

Effects of aging, hearing loss, and anatomical location on thresholds of inferior colliculus neurons in C57BL/6 and CBA mice

1986 • 210 citations

Manipulating the mouse embryo (2nd edn)

1995 • 200 citations

Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2

1997 • 198 citations

Evidence that the aversive effects of opioid antagonists and ?-agonists are centrally mediated

1989 • 193 citations

δ-Opioid receptor subtypes and cross-talk with μ-receptors

1993 • 188 citations

Antisense mapping the MOR‐1 opioid receptor: evidence for alternative splicing and a novel morphine‐6β‐glucuronide receptor

1995 • 181 citations

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

1994 • 181 citations

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells.

1991 • 179 citations

Hereditary covariations of neuronal circuitry and behavior: Correlations between the proportions of hippocampal synaptic fields in the regio inferior and two-way avoidance in mice and rats

1983 • 178 citations

Drugs of abuse: behavioural principles, methods and terms

1992 • 177 citations

Expression of two variants of the human μ opioid receptor mRNA in SK‐N‐SH cells and human brain

1994 • 172 citations

Altered Hematopoiesis, Behavior, and Sexual Function in μ Opioid Receptor–deficient Mice

1997 • 171 citations

Blockade of morphine reward through the activation of κ-opioid receptors in mice

1993 • 164 citations

Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6beta-glucuronide antinociception.

1997 • 154 citations

Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter

1996 • 151 citations

Opioid and Nonopioid Swim Stress-Induced Analgesia: A Parametric Analysis in Mice

1996 • 150 citations

Stress-induced behavioral responses and multiple opioid systems in the brain

1995 • 136 citations

Assessing the effects of the 129/Sv genetic background on swimming navigation learning in transgenic mutants: a study using mice with a modified β-amyloid precursor protein gene

1997 • 128 citations

The μ-opioid receptor is necessary for [d-Pen2,d-Pen5]enkephalin-induced analgesia

1997 • 126 citations

Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy.

1993 • 125 citations

Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse.

1990 • 113 citations

Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.

1994 • 109 citations

Gene-targeting studies: new methods, old problems

1996 • 107 citations

Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/ and DBA/2 strains

1995 • 101 citations

Nociceptive and morphine antinociceptive sensitivity of 129 and C57BL/6 inbred mouse strains: Implications for transgenic knock‐out studies

1997 • 98 citations

Voluntary consumption of morphine in 15 inbred mouse strains

1993 • 95 citations

Action at the mu receptor is sufficient to explain the supraspinal analgesic effect of opiates

1988 • 90 citations

Modulation of transmitter and hormone release by multiple neuronal opioid receptors

2005 • 89 citations

Analgesic synergy and improved motor function produced by combinations of μ-δ- and μ-κ-opioids

1990 • 86 citations

Tests of Genetic Allelism between Four Inbred Mouse Strains with Absent Corpus Callosum

1991 • 76 citations

Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine

1992 • 72 citations

Lack of morphine and enkephalin tolerance in 129/SvEv mice: evidence for a NMDA receptor defect.

1998 • 63 citations

Gene Targeting in ES Cells

1995 • 57 citations

The effect of genotype on sensitivity to inflammatory nociception: characterization of resistant (A/J) and sensitive (C57BL/6J) inbred mouse strains

1998 • 55 citations

Murine Chromosomal Location of the μ and κ Opioid Receptor Genes

1994 • 53 citations

Endogenous opiates: 1995

1996 • 43 citations

Beta-endorphin: a highly selective endogenous opioid agonist for presynaptic mu opioid receptors.

1991 • 38 citations

U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs

1994 • 35 citations

Promoter Region and Alternatively Spliced Exons of the Rat μ‐Opioid Receptor Gene

1996 • 33 citations

Systemic administration of (Tyr-D-Ser(O-tert-butyl)-Gly-Phe-Leu-Thr(O-tert-butyl), a highly selective delta opioid agonist, induces mu receptor-mediated analgesia in mice.

1991 • 30 citations

A new hybrid mouse model for agenesis of the corpus callosum

1994 • 25 citations

Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker

1993 • 24 citations

Background genes: out of sight, but not out of brain....

1997 • 24 citations

Retarded growth of the medial septum: a major gene effect in acallosal mice

1994 • 23 citations

Opioid κ receptors correlate with the development of conditioned suppression of motility in mice

1988 • 6 citations

The Identification of Neuropeptide Gene Regulatory Elements in Transgenic Mice

2003 • 5 citations