Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

1992 • 973 citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1987 • 786 citations

Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

1990 • 428 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo

1989 • 417 citations

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

1991 • 338 citations

The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos

1991 • 333 citations

Altering Genes in Animals by Gene Targeting

1992 • 224 citations

Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells.

1991 • 187 citations

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells.

1991 • 179 citations

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination

1989 • 166 citations

Production of Homozygous Mutant ES Cells with a Single Targeting Construct

1992 • 140 citations

Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy.

1993 • 125 citations

Fungal recombination

1985 • 121 citations

Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.

1990 • 121 citations

Double-strand gap repair in a mammalian gene targeting reaction.

1991 • 82 citations

Cotransformation and gene targeting in mouse embryonic stem cells.

1991 • 77 citations

Target Frequency and Integration Pattern for Insertion and Replacement Vectors in Embryonic Stem Cells

1991 • 64 citations

Testing an “In-Out” Targeting Procedure for Making Subtle Genomic Modifications in Mouse Embryonic Stem Cells

1991 • 46 citations

Site-Directed Point Mutations in Embryonic Stem Cells: a Gene-Targeting Tag-and-Exchange Strategy

1993 • 36 citations

Cotransformation and Gene Targeting in Mouse Embryonic Stem Cells

1991 • 35 citations

Double-Strand Gap Repair in a Mammalian Gene Targeting Reaction

1991 • 31 citations

Investigation of Coelectroporation as a Method for Introducing Small Mutations into Embryonic Stem Cells

1992 • 22 citations