Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

1986 • 1,509 citations

A Comparison of the Social Postures of Some Common Laboratory Rodents

1963 • 1,158 citations

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

1984 • 951 citations

The relation between fear induced by novel stimulation and exploratory drive.

1955 • 900 citations

8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site

1983 • 869 citations

The Rat: A Study in Behavior

1966 • 649 citations

Thigmotaxis as a test for anxiolytic activity in rats

1988 • 646 citations

Anxiogenic stimuli in the elevated plus-maze

1993 • 626 citations

Functional Correlates of Serotonin 5-HT₁Recognition Sites

1988 • 564 citations

An Analysis of the Social Behaviour of the Male Laboratory Rat

1963 • 452 citations

Pharmacological properties of GR38032F, a novel antagonist at 5‐HT₃ receptors

1988 • 378 citations

Evidence that mCPP may have behavioural effects mediated by central 5‐HT_1C receptors

1988 • 299 citations

m-Chlorophenylpiperazine as a probe of serotonin function

1991 • 291 citations

Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists

1989 • 285 citations

5HT drugs in animal models of anxiety

1993 • 261 citations

Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze

1989 • 228 citations

Serotonin receptor subtypes : basic and clinical aspects

1991 • 217 citations

5-Ht1a Agonists, 5-Ht3 Antagonists and Benzodiazepines: Their Comparative Behavioural Pharmacology

1991 • 194 citations

An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone

1989 • 192 citations

Effects of diazepam on behavioural and antinociceptive responses to the elevated plus-maze in male mice depend upon treatment regimen and prior maze experience

1992 • 172 citations

An ethological analysis of the effects of chlordiazepoxide and bretazenil (Ro 16???6028) in the murine elevated plus-maze

1993 • 171 citations

Diazepam changes risk assessment in an anxiety/defense test battery

1990 • 161 citations

Species-specific behavior and acquisition of avoidance behavior in rats.

1972 • 159 citations

Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors

1987 • 157 citations

Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat

1987 • 156 citations

Antinociceptive effects of elevated plus-maze exposure: influence of opiate receptor manipulations

1990 • 138 citations

Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plus-maze

1992 • 133 citations

Characterization of MDL 73005EF as a 5‐HT_1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam

1990 • 113 citations

Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

1989 • 109 citations

Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test

1989 • 108 citations

The biological basis of anxiety

1985 • 99 citations

Stretched attend posture, a non-social form of ambivalence, is sensitive to a conflict-reducing drug action

1986 • 86 citations

Behavioral differences in an elevated plus-maze: correlation between anxiety and decreased number of GABA and benzodiazepine receptors in mouse cerebral cortex

1988 • 79 citations

The effects of 5-HT1B characterizing agents in the mouse elevated plus-maze

1990 • 78 citations

The anxiety/defense test battery: Influence of gender and ritanserin treatment on antipredator defensive behavior

1992 • 67 citations

Comparison of acute and chronic treatment of various serotonergic agents with those of diazepam and idazoxan in the rat elevated X-maze

1992 • 66 citations

Serotonin, sleep and mental disorder

1991 • 66 citations

Resistance of baseline activity in the elevated pius-maze to exogenous influences

1992 • 65 citations

Reversal of increased anxiety during benzodiazepine withdrawal: Evidence for an anxiogenic endogenous ligand for the benzodiazepine receptor

1988 • 59 citations

Ondansetron, an antagonist of 5-HT3 receptors, antagonizes the anti-exploratory effect of caerulein, an agonist of CCK receptors, in the elevated plus-maze

1993 • 57 citations

Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions

1992 • 57 citations

A Handbook of Introductory Statistical Methods.

1988 • 56 citations

Effects of benzodiazepine receptor antagonist, flumazenil, on antinociceptive and behavioural responses to the elevated plus-maze in mice

1991 • 45 citations

“Paradoxical” effects of morphine on antipredator defense reactions in wild and laboratory rats

1991 • 41 citations

Efficacy and tolerability of moclobemide compared with fluvoxamine in depressive disorder (DSM III)

1992 • 41 citations

Profiles of the antipanic compounds, triazolobenzodiazepines and phenelzine, in two animal tests of anxiety

1988 • 38 citations

m-Chlorophenylpiperazine enhances neophobic and anxious behaviour in mice

1991 • 38 citations

Effects of 8-OH-DPAT and buspirone in a passive avoidance test and in the elevated plus-maze test in rats

1991 • 33 citations

A step in the right direction: comment on '5-HT and mechanisms of defence'

1991 • 15 citations

[The effect of diazepam on exploratory behavior and its strain differences in inbred rats].

1990 • 10 citations

Effects of chlordiazepoxide, pentobarbital, buspirone, chlorpromazine, and morphine in the stretched attend posture (SAP) test

1988 • 9 citations

PHARMACOLOGICAL EVALUATION OF THE ELEVATED ZERO-MAZE AS A MODEL OF ANXIETY IN RATS

1993 • 2 citations