Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
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References (67)
The Rat Brain in Stereotaxic Coordinates
1982 • 53,055 citations
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
1988 • 4,617 citations
Brain Dopamine and Reward
1989 • 1,899 citations
Anatomy of CNS opioid receptors
1988 • 1,178 citations
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
1988 • 913 citations
Psychotomimesis Mediated by κ Opiate Receptors
1986 • 822 citations
Microdialysis—Theory and application
1990 • 651 citations
Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems
1982 • 560 citations
The mesolimbic dopamine system : from motivation to action
1991 • 555 citations
The Effects of Opioid Peptides on Dopamine Release in the Nucleus Accumbens: An In Vivo Microdialysis Study
1990 • 539 citations
Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists
1987 • 529 citations
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats
1992 • 525 citations
Opioid Peptides Endorphins in Pituitary and Brain
1976 • 518 citations
Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
1985 • 516 citations
The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties
1982 • 509 citations
Morphine-induced activation of A10 dopamine neurons in the rat
1983 • 485 citations
Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.
1993 • 458 citations
The neuropharmacological basis of reward
1991 • 457 citations
Conditioned place preference as a measure of drug reward.
1989 • 456 citations
Evidence for two separate opiate peptide neuronal systems
1978 • 413 citations
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
1988 • 399 citations
Enkephalin action on the mesolimbic system: a dopamine-dependent and a dopamine-independent increase in locomotor activity.
1983 • 355 citations
Heroin reward is dependent on a dopaminergic substrate
1981 • 333 citations
Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system
1983 • 309 citations
Euphorigenic drugs: effects on the reward pathways of the brain.
1979 • 299 citations
Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors.
1993 • 274 citations
Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists.
1990 • 265 citations
Activation of hypothalamic β-endorphin pools by reward induced by highly palatable food
1983 • 245 citations
Endorphins in Mental Health Research
1979 • 222 citations
SCH 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine-receptor blockade?
1989 • 211 citations
Action of drugs of abuse on brain reward systems: An update with specific attention to opiates
1982 • 194 citations
Evidence that the aversive effects of opioid antagonists and ?-agonists are centrally mediated
1989 • 193 citations
Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.
1980 • 182 citations
Motivational properties of opioids: evidence that an activation of σ-receptors mediates reinforcement processes
1987 • 167 citations
Non-competitive antagonists are potent activators of ventral tegmental A10 dopamine neurons
1990 • 157 citations
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex
1990 • 157 citations
Motivational effects of opioids: influence of D-1 versus D-2 receptor antagonists
1988 • 156 citations
Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats
1991 • 155 citations
The neurobiology of Drug and alcohol addiction
1991 • 154 citations
Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents
1990 • 135 citations
Rewarding properties of β-endorphin as measured by conditioned place preference
1987 • 123 citations
Microdialysis measurement of in vivo neuropeptide release
1990 • 113 citations
Involvement of central μ and δ opioid receptors in mediating the reinforcing effects of β-endorphin in the rat
1990 • 109 citations
Dependence creating properties of lipotropin C-fragment (β-endorphin): Evidence for its internal control of behavior
1979 • 102 citations
[3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain.
1989 • 101 citations
Antagonist-induced opioid receptor up-regulation. II. Regionally specific modulation of mu, delta and kappa binding sites in rat brain revealed by quantitative autoradiography.
1988 • 97 citations
Aversive properties of naloxone in non-dependent (naive) rats may involve blockade of central ?-endorphin
1985 • 88 citations
Stereospecific aversive property of narcotic antagonists in morphine-free rats
1978 • 81 citations
Molecular and Cellular Aspects of the Drug Addictions
1989 • 79 citations
Opiate influences on nucleus accumbens neuronal electrophysiology: dopamine and non-dopamine mechanisms
1989 • 78 citations
Neuroanatomical substrates mediating the aversive effects of D-1 dopamine receptor antagonists
1991 • 76 citations
Identification of the opiosd receptor types mediating β-endorphin-induced alterations in dopamine release in the nucleus accumbens
1990 • 76 citations
Further evidence for a role of δ-opiate receptors in the presynaptic regulation of newly synthesized dopamine release
1986 • 74 citations
Interaction between Endogenous Opioids and Dopamine within the Nucleus Accumbensa
1992 • 70 citations
β-endorphin in brain limbic structures as neurochemical correlate of psychic dependence on drugs
1989 • 65 citations
Neurobiology of drug abuse.
1987 • 61 citations
Opioid peptides (endorphins) in pituitary and brain
1977 • 57 citations
Autoradiographic localization of delta opioid receptors within the mesocorticolimbic dopamine system using radioiodinated [2‐d‐penicillamine, 5‐d‐penicillamine]enkephalin (125I‐DPDPE)
1990 • 56 citations
Endogenous opiate reward induced by an enkephalinase inhibitor, thiorphan, injected into the ventral midbrain.
1984 • 51 citations
Effect of Varying the Ionic Concentration of a Microdialysis Perfusate on Basal Striatal Dopamine Levels in Awake Rats
1991 • 50 citations
Naloxone as a negative reinforcer in rhesus monkeys: effects of dose, schedule, and narcotic regimen.
1975 • 44 citations
Neurochemical Aspects of Addiction: Opioids and Other Drugs of Abuse
1989 • 37 citations
Opiate reinforcement and naloxone aversion, as revealed by place preference paradigm, in two strains of rats
1987 • 28 citations
Augmentation of morphine-induced changes in brain monoamine metabolism after chronic naltrexone treatment.
1990 • 23 citations
Opioids and Motivation
1987 • 17 citations
Motivational Effects of Opioids: Neurochemical and Neuroanatomical Substrates
1991 • 11 citations
The M Esolimbic Dopamine System: From Maturation to Action. P. Willner and J. Scheel-Kruger (Eds). pp. 674. John Wiley, Chichester.
1991 • 1 citations