Analgesic synergy and improved motor function produced by combinations of μ-δ- and μ-κ-opioids

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.

1957 • 1,671 citations

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

Intrathecal and Epidural Administration of Opioids

1984 • 1,198 citations

U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

1983 • 795 citations

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

1983 • 737 citations

Multiple opiate receptor sites on primary afferent fibres

1980 • 621 citations

Spinal opiate analgesia: Characteristics and principles of action

1981 • 552 citations

Studies on the direct spinal action of narcotics in the production of analgesia in the rat.

1977 • 543 citations

Studies in the Primate on the Analgetic Effects Associated with Intrathecal Actions of Opiates,α-Adrenergic Agonists and Baclofen

1981 • 533 citations

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

1981 • 503 citations

Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

1984 • 417 citations

In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat.

1984 • 391 citations

A CLASSIFICATION OF OPIATE RECEPTORS THAT MEDIATE ANTINOCICEPTION IN ANIMALS

1980 • 346 citations

The Physiology and Pharmacology of Spinal Opiates

1985 • 303 citations

Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms.

1985 • 271 citations

Mu and delta receptors: Their role in analgesia and in the differential effects of opioid peptides on analgesia

1982 • 233 citations

Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level.

1983 • 193 citations

Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5] enkephalin in the mouse

1988 • 169 citations

Analgetic actions of intrathecal opiates in cat and primate

1978 • 166 citations

The contribution of training to sensitivity in the nociceptive paw-withdrawal test

1989 • 163 citations

Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.

1983 • 153 citations

In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord

1982 • 148 citations

Cerebral delta opioid receptors mediate analgesia but not the intestinal motility effects of intracerebroventricularly administered opioids.

1984 • 136 citations

In vivo studies on spinal opiate receptor systems mediating antinociception. I. Mu and delta receptor profiles in the primate.

1983 • 133 citations

Dissociation of opioid antinociception and central gastrointestinal propulsion in the mouse: studies with naloxonazine.

1988 • 126 citations

Allosteric coupling between morphine and enkephalin receptors in vitro.

1982 • 116 citations

Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice.

1989 • 103 citations

Opiate and peptide interaction: Effect of enkephalins on morphine analgesia

1980 • 102 citations

Morphine allosterically modulates the binding of [3H]leucine enkephalin to a particulate fraction of rat brain.

1982 • 91 citations

Production of Hyperalgesic Prostaglandins by Sympathetic Postganglionic Neurons

1989 • 83 citations

Antinociceptive effects of intrathecally administered human β-endorphin in the rat and cat

1978 • 72 citations

Potentiation of pentazocine analgesia by low-dose naloxone.

1988 • 69 citations

The potentiation of spinal analgesia by leucine enkephalin

1980 • 58 citations

Morphine and met-enkephalin effects of sural aδ- afferent terminal excitability

1978 • 50 citations

In vivo comparison of the receptor populations acted upon in the spinal cord by morphine and pentapeptides in the production of analgesia

1978 • 49 citations

κ- and δ-opioid agonists synergize to produce potent analgesia

1990 • 48 citations

Actions of mu, delta and kappa opioid agonists and antagonists on mouse primary afferent neurons in culture.

1987 • 46 citations

Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor.

1989 • 46 citations

FURTHER STUDIES ON OPIATE RECEPTORS THAT MEDIATE ANTI‐NOCICEPTION: TOOTH PULP STIMULATION IN THE DOG

1980 • 36 citations

Influence of certain parameters on the performance of mice on the rotarod.

1967 • 28 citations

Evidence for opioid receptor interactions in vivo.

1988 • 3 citations