Hepatitis b Viruses and Hepatocellular Carcinoma

The p53 tumour suppressor gene

1991 • 3,871 citations

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

1982 • 1,429 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

Origin and evolution of retroelements based upon their reverse transcriptase sequences.

1990 • 1,351 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Hepatitis B virus.The major etiology of hepatocellular carcinoma

1988 • 1,308 citations

A "New" Antigen in Leukemia Sera

1965 • 1,302 citations

The hepatitis B virus

1985 • 1,219 citations

MUTATION PREVENTING FORMATION OF HEPATITIS B e ANTIGEN IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION

1989 • 1,210 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

1990 • 1,108 citations

THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES

1987 • 1,046 citations

Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli

1979 • 992 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

Hepatitis B Virus

1991 • 860 citations

Acute Hepatitis B Virus Infection: Relation of Age to the Clinical Expression of Disease and Subsequent Development of the Carrier State

1985 • 823 citations

E Antigen and Anti-E in the Serum of Asymptomatic Carrier Mothers as Indicators of Positive and Negative Transmission of Hepatitis B Virus to Their Infants

1976 • 724 citations

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 • 715 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

1978 • 657 citations

Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells

1986 • 652 citations

Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma

1980 • 610 citations

THE e ANTIGEN AND VERTICAL TRANSMISSION OF HEPATITIS B SURFACE ANTIGEN

1977 • 601 citations

Hepatitis B virus genes and their expression in E. coli

1979 • 584 citations

Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

1990 • 578 citations

Mutations in the Precore Region of Hepatitis B Virus DNA in Patients with Fulminant and Severe Hepatitis

1991 • 536 citations

Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen

1990 • 525 citations

Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus

1986 • 523 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

The multistep nature of cancer development.

1984 • 510 citations

Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals: a review.

1969 • 510 citations

Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus

1980 • 506 citations

RUBELLA VACCINATION

1973 • 502 citations

New Specificities in Australia Antigen Positive Sera Distinct from the Le Bouvier Determinants

1972 • 497 citations

A Hepatitis B Virus Mutant Associated with an Epidemic of Fulminant Hepatitis

1991 • 468 citations

Oncogenes in solid human tumours

1982 • 467 citations

Hepatitis B Virus DNA in Patients with Chronic Liver Disease and Negative Tests for Hepatitis B Surface Antigen

1985 • 466 citations

Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus

1983 • 464 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

p53 mutation in hepatocellular carcinoma after aflatoxin exposure

1991 • 448 citations

Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw

1983 • 426 citations

Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

1990 • 413 citations

A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA.

1990 • 412 citations

Hepatitis B virus DNA contains a glucocorticoid-responsive element.

1986 • 400 citations

Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma

1986 • 399 citations

Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes.

1982 • 395 citations

Analysis of Liver Disease, Nuclear HBcAg, Viral Replication, and Hepatitis B Virus DNA in Liver and Serum of HBcAg Vs. Anti-HBe Positive Carriers of Hepatitis B Virus

1983 • 385 citations

Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis.

1991 • 370 citations

A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.

1980 • 367 citations

Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice

1990 • 363 citations

Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion

1984 • 358 citations

Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity

1990 • 355 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.

1981 • 351 citations

Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen.

1986 • 345 citations

DETECTION OF HEPATITIS B VIRUS DNA IN LIVER AND SERUM: A DIRECT APPRAISAL OF THE CHRONIC CARRIER STATE

1981 • 333 citations

Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification

1990 • 332 citations

Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters.

1988 • 323 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

TRANSMISSION OF HEPATITIS B FROM HEPATITIS-B-SERONEGATIVE SUBJECTS

1988 • 316 citations

Replication strategy of human hepatitis B virus

1987 • 314 citations

Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from Dane particles.

1975 • 309 citations

Cloning and structural analyses of hepatitis B virus DNAs, subtypeadr

1983 • 309 citations

Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription

1990 • 309 citations

Nucleotide sequence of a cloned duck hepatitis B virus genome: comparison with woodchuck and human hepatitis B virus sequences

1984 • 299 citations

Nucleotide sequence of a cloned woodchuck hepatitis virus genome: comparison with the hepatitis B virus sequence

1982 • 296 citations

Biochemical and Genetic Evidence for the Hepatitis B Virus Replication Strategy

1986 • 296 citations

In vitro experimental infection of primary duck hepatocyte cultures with duck hepatitis B virus

1986 • 294 citations

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

1990 • 292 citations

Integration of hepatitis B virus sequences and their expression in a human hepatoma cell

1980 • 291 citations

A human hepatitis B viral enhancer element.

1985 • 286 citations

The P gene product of hepatitis B virus is required as a structural component for genomic RNA encapsidation

1990 • 285 citations

Hepatitis B virus DNA in the sera of HBsAg carriers: A marker of active hepatitis B virus replication in the liver

1981 • 285 citations

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator

1990 • 284 citations

A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma

1987 • 282 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

Ethanol-induced liver fibrosis in rats fed high fat diet

1986 • 279 citations

Hepatocarcinogenicity of the woodchuck hepatitis virus.

1987 • 273 citations

Mutagenesis and carcinogenesis: Endogenous and exogenous factors

1989 • 266 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Relationship Between Hepatocellular Carcinoma and Cirrhosis

1984 • 264 citations

Identification of HBV variants which cannot produce pre-core derived HBeAg and may be responsible for severe hepatitis

1989 • 263 citations

Highly preferred targets for retrovirus integration

1988 • 262 citations

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.

1991 • 262 citations

Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus

1989 • 250 citations

Identification of integrated hepatitis B virus DNA and expression of viral RNA in an HBsAg-producing human hepatocellular carcinoma cell line

1980 • 247 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

Signals regulating hepatitis B surface antigen transcription

1983 • 246 citations

Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours

1990 • 245 citations

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.

1990 • 236 citations

Effects of hepatitis B virus, alcohol drinking, cigarette smoking and familial tendency on hepatocellular carcinoma

1991 • 235 citations

Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation.

1984 • 234 citations

Allelotype study of primary hepatocellular carcinoma

1991 • 223 citations

Host-independent evolution and a genetic classification of the hepadnavirus family based on nucleotide sequences.

1989 • 221 citations

Association of Crossover Points with Topoisomerase I Cleavage Sites: A Model for Nonhomologous Recombination

1985 • 218 citations

Immunochemical structure of hepatitis B e antigen in the serum.

1983 • 217 citations

Selective killing of hepatitis B envelope antigen-specific B cells by class I-restricted, exogenous antigen-specific T lymphocytes

1990 • 208 citations

Detection of hepatitis B virus DNA in mononuclear blood cells.

1984 • 206 citations

Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region

1990 • 205 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma.

1987 • 204 citations

Common evolutionary origin of hepatitis B virus and retroviruses.

1986 • 204 citations

Deletion in Chromosome 11p Associated with a Hepatitis B Integration Site in Hepatocellular Carcinoma

1985 • 199 citations

Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice.

1990 • 199 citations

Morphogenetic and regulatory effects of mutations in the envelope proteins of an avian hepadnavirus

1991 • 198 citations

The amino-terminal domain of the hepadnaviral P-gene encodes the terminal protein (genome-linked protein) believed to prime reverse transcription.

1988 • 198 citations

Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization

1984 • 196 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

Expression and replication of hepatitis B virus genome in transgenic mice.

1989 • 196 citations

Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation

1991 • 194 citations

Immune response to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg.

1987 • 193 citations

Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma

1988 • 192 citations

DNA amplification is rare in normal human cells.

1990 • 192 citations

Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma.

1989 • 191 citations

INTRAVENOUS FEEDING

1974 • 188 citations

Role of the v-erbA and v-erbB oncogenes of avian erythroblastosis virus in erythroid cell transformation

1983 • 188 citations

Isolation and characterization of a hepatitis B virus endemic in herons

1988 • 187 citations

Relation of the hepatitis B virus carrier state to hepatocellular carcinoma

1987 • 186 citations

The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation

1987 • 182 citations

HTLV-1 Tax induces expression of various immediate early serum responsive genes.

1991 • 177 citations

Three recently described animal virus models for human hepatitis B virus

1981 • 175 citations

A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state.

1988 • 174 citations

The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells

1989 • 169 citations

The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid

1987 • 169 citations

Association of a precore genomic variant of hepatitis B virus with fulminant hepatitis

1991 • 169 citations

Antibodies to Peptides Detect New Hepatitis B Antigen: Serological Correlation with Hepatocellular Carcinoma

1985 • 169 citations

Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto-oncogene expression

1991 • 168 citations

A Liver-Specific Enhancer in the Core Promoter Region of Human Hepatitis B Virus

1989 • 168 citations

Hepatitis B virus transcription in the infected liver.

1984 • 167 citations

Expression of the precore region of an avian hepatitis B virus is not required for viral replication

1987 • 166 citations

Hepatitis B virus and hepatitis B-related viral infection in renal transplant recipients

1988 • 166 citations

Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences

1987 • 165 citations

Disease specificity of nondefective Friend and Moloney murine leukemia viruses is controlled by a small number of nucleotides

1987 • 164 citations

Nucleotide Sequence of a Cloned Hepatitis B Virus Genome, Subtype ayr: Comparison with Genomes of the Other Three Subtypes

1986 • 163 citations

Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein.

1990 • 162 citations

Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas

1988 • 161 citations

The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

1988 • 161 citations

Familial Clustering of Asymptomatic Carriers of Australia Antigen and Patients with Chronic Liver a Disease or Primary Liver Cancer

1972 • 161 citations

Evidence that a capped oligoribonucleotide is the primer for duck hepatitis B virus plus-strand DNA synthesis

1986 • 160 citations

Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses.

1990 • 159 citations

The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.

1990 • 159 citations

Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat.

1984 • 156 citations

Viral hepatitis B in neonates and infants

1973 • 156 citations

Detection of hepatitis B virus sequences in serum by using in vitro enzymatic amplification

1988 • 156 citations

Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.

1986 • 155 citations

Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus

1984 • 155 citations

Subtype ayw variant of hepatitis B virus

1985 • 154 citations

A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes.

1988 • 153 citations

Woodchuck hepatitis and hepatocellular carcinoma: Correlation of histologic with virologic observations

1981 • 152 citations

Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting

1989 • 151 citations

Specific Expression of Hepatitis B Surface Antigen (HBsAg) in Transgenic Mice

1985 • 149 citations

Viral persistence

1989 • 148 citations

HEPATITIS B VIRUS INFECTION IN TWO GAMBIAN VILLAGES

1983 • 148 citations

A prospective study on the development of hepatocellular carcinoma from liver cirrhosis with persistent hepatitis B virus infection

1980 • 148 citations

Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: Presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections

1989 • 147 citations

Emergence of and takeover by hepatitis B virus (HBV) with rearrangements in the pre-S/S and pre-C/C genes during chronic HBV infection

1991 • 146 citations

A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA.

1990 • 145 citations

Transcripts and the putative RNA pregenome of duck hepatitis B virus: Implications for reverse transcription

1985 • 143 citations

Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide.

1986 • 142 citations

Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues.

1990 • 140 citations

Mutation rate of the hepadnavirus genome

1989 • 139 citations

Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks

1986 • 139 citations

Hepatitis B virus X gene can transactivate heterologous viral sequences.

1989 • 137 citations

Evidence for a deficiency of interferon production in patients with chronic hepatitis B virus infection acquired in adult life

1986 • 137 citations

Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome

1988 • 136 citations

Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice.

1987 • 135 citations

Presence of HBV DNA in spermatozoa: A possible vertical transmission of HBV via the germ line

1985 • 134 citations

Synthesis and encapsidation of duck hepatitis B virus reverse transcriptase do not require formation of core-polymerase fusion proteins

1989 • 132 citations

Expression of Hepatitis B Viral Core Region in Mammalian Cells

1986 • 132 citations

Hepatitis B defective virus with rearrangements in the PreS gene during chronic HBV infection

1991 • 132 citations

Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen.

1987 • 131 citations

Expression of the hepatitis B virus X gene in mammalian cells.

1987 • 131 citations

Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein

1987 • 130 citations

T- and B-cell recognition of hepatitis B viral antigens

1988 • 130 citations

The secretory core protein of human hepatitis B virus is expressed on the cell surface

1989 • 130 citations

Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas.

1991 • 128 citations

High correlation between molecular alterations of the c-myc oncogene and carcinoma of the uterine cervix.

1987 • 127 citations

Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virus.

1986 • 126 citations

Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of woodchucks

1982 • 125 citations

The Complete Nucleotide Sequence of the Genome of a Hepatitis B Virus Isolated from a Naturally Infected Chimpanzee

1988 • 125 citations

Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas.

1991 • 124 citations

Integration of hepatitis B virus DNA: Evidence for integration in the single-stranded gap

1983 • 123 citations

Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant

1985 • 122 citations

Transcription of the hepatitis B surface antigen gene in mouse cells transformed with cloned viral DNA

1982 • 121 citations

The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinase

1990 • 121 citations

Protein covalently bound to minus-strand DNA intermediates of duck hepatitis B virus

1983 • 121 citations

Viral nucleic acid synthesis and antigen accumulation in pancreas and kidney of Pekin ducks infected with duck hepatitis B virus.

1983 • 120 citations

Hepadnavirus infection of peripheral blood lymphocytes in vivo: woodchuck and chimpanzee models of viral hepatitis

1986 • 120 citations

Multiple nuclear proteins in liver cells are bound to hepatitis B virus enhancer element and its upstream sequences.

1987 • 119 citations

Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children

1987 • 118 citations

Nucleotide sequence of a cloned woodchuck hepatitis virus genome: evolutional relationship between hepadnaviruses

1985 • 117 citations

cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA

1991 • 116 citations

Hepatitis B virus transcript produced by RNA splicing

1989 • 116 citations

Hepatitis B virus infection in patients with idiopathic liver disease

1991 • 116 citations

Transcriptional factor C/EBP binds to and transactivates the enhancer element II of the hepatitis B virus

1991 • 115 citations

Hepatitis B virus (HBV) promoters are regulated by the HBV enhancer in a tissue-specific manner

1989 • 115 citations

The genome of hepatitis B virus contains a second enhancer: cooperation of two elements within this enhancer is required for its function

1990 • 114 citations

Precore sequence of hepatitis B virus inducing e antigen and membrane association of the viral core protein

1986 • 114 citations

Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas

1987 • 113 citations

Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line

1985 • 113 citations

Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site.

1985 • 112 citations

Three envelope proteins of hepatitis B virus: large S, middle S, and major S proteins needed for the formation of Dane particles

1991 • 112 citations

Electron microscopy and immunoelectronmicroscopy of cytoplasmic hepatitis B antigen in hepatocytes.

1974 • 110 citations

N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas.

1989 • 109 citations

HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis

1991 • 109 citations

Cellular factors that interact with the hepatitis B virus enhancer.

1989 • 108 citations

Persistence of hepatitis B viral DNA after serological recovery from hepatitis B virus infection

1991 • 108 citations

Detection of Hepatitis B Virus-specific DNA in the Genomes of Human Hepatocellular Carcinoma and Liver Cirrhosis Tissues

1981 • 108 citations

Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules

1991 • 107 citations

Identification of a promoter element located upstream from the hepatitis B virus X gene.

1987 • 103 citations

Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo

1991 • 102 citations

Mutational analysis of hepatitis B surface antigen particle assembly and secretion

1991 • 101 citations

Initiation and termination of duck hepatitis B virus DNA synthesis during virus maturation

1987 • 100 citations

The human hepatitis B virus enhancer requires trans-acting cellular factor(s) for activity.

1986 • 99 citations

The HBV HBX gene expressed in E. coli is recognised by sera from hepatitis patients.

1985 • 99 citations

Identification and transmission of hepatitis B virus-related variants.

1986 • 99 citations

Topoisomerase I-mediated integration of hepadnavirus DNA in vitro

1991 • 99 citations

Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle.

1986 • 98 citations

Evidence of extrachromosomal forms of hepatitis B viral DNA in a bone marrow culture obtained from a patient recently infected with hepatitis B virus.

1984 • 98 citations

Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region

1984 • 96 citations

Characterization of the major duck hepatitis B virus core particle protein

1989 • 96 citations

Transcription of woodchuck hepatitis virus in the chronically infected liver.

1985 • 95 citations

c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet.

1989 • 95 citations

DNA sequence studies of simian virus 40 chromosomal excision and integration in rat cells

1984 • 93 citations

An in vitro system for infection with hepatitis B virus that uses primary human fetal hepatocytes.

1989 • 91 citations

Mapping of the cohesive overlap of duck hepatitis B virus DNA and of the site of initiation of reverse transcription

1984 • 91 citations

Status of c-myc, p53 and retinoblastoma genes in human papillomavirus positive and negative squamous cell carcinomas of the anus.

1991 • 91 citations

High affinity binding site for nuclear factor I next to the hepatitis B virus S gene promoter.

1986 • 90 citations

Hepatitis B virus DNA in mononuclear blood cells

1986 • 90 citations

A new enhancer element, ENII, identified in the X gene of hepatitis B virus

1990 • 88 citations

Hepatitis B virus structure and biology

1989 • 88 citations

Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines

1990 • 87 citations

Inversely repeating integrated hepatitis B virus DNA and cellular flanking sequences in the human hepatoma-derived cell line huSP.

1985 • 86 citations

Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA.

1991 • 86 citations

Structure of hepatitis B Dane particle DNA before and after the Dane particle DNA polymerase reaction

1977 • 86 citations

Transcriptional control elements of hepatitis B surface antigen gene.

1986 • 86 citations

Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region

1987 • 86 citations

Core and E antigen synthesis in rodent cells transformed with hepatitis B virus DNA is associated with greater than genome length viral messenger RNAs

1983 • 85 citations

Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas.

1990 • 85 citations

Identification of a doubly spliced viral transcript joining the separated domains for putative protease and reverse transcriptase of hepatitis B virus

1989 • 85 citations

Natural history of woodchuck hepatitis virus infections during the course of experimental viral infection: molecular virologic features of the liver and lymphoid tissues

1989 • 83 citations

Expression of the hepatitis B virus core gene in vitro and in vivo

1987 • 83 citations

Novel N-Terminal Amino Acid Sequence Required for Retention of a Hepatitis B Virus Glycoprotein in the Endoplasmic Reticulum

1989 • 82 citations

Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus.

1991 • 81 citations

Neonatal Onset of the Hepatitis-Associated-Antigen Carrier State

1972 • 81 citations

Characterization and genetic analysis of alternatively spliced transcripts of hepatitis B virus in infected human liver tissues and transfected HepG2 cells

1991 • 81 citations

Features of two hepatitis B virus (HBV) DNA integrations suggest mechanisms of HBV integration

1989 • 80 citations

Hepatitis B virus integration in hepatitis B virus-related hepatocellular carcinoma in childhood

1991 • 80 citations

Hepatitis B Viral DNA Molecules Have Cohesive Ends

1979 • 79 citations

The viral transcriptional regulatory region upstream of the E6 and E7 genes is a major determinant of the differential immortalization activities of human papillomavirus types 16 and 18

1991 • 78 citations

Mitogen-Induced Replication of Woodchuck Hepatitis Virus in Cultured Peripheral Blood Lymphocytes

1988 • 78 citations

Expression of the hepatitis B virus surface, core and E antigen genes by stable rat and mouse cell lines

1982 • 78 citations

The ubiquitous transcription factor Oct-1 and the liver-specific factor HNF-1 are both required to activate transcription of a hepatitis B virus promoter.

1991 • 77 citations

Preferred translation of human hepatitis B virus polymerase from core protein- but not from precore protein-specific transcript

1990 • 76 citations

Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks.

1990 • 76 citations

Low Incidence of Point Mutation of c‐Ki‐ras and N‐ras Oncogenes in Human Hepatocellular Carcinoma

1989 • 75 citations

Hepatitis B virus polypeptide X: expression in Escherichia coli and identification of specific antibodies in sera from hepatitis B virus-infected humans

1986 • 75 citations

Cloning and analysis of integrated hepatitis virus sequences from a human hepatoma cell line

1984 • 75 citations

Expression mechanism of the hepatitis B virus (HBV) C gene and biosynthesis of HBe antigen

1989 • 74 citations

Hybrid hepatitis B virus-host transcripts in a human hepatoma cell.

1985 • 74 citations

Duck hepatitis B virus DNA in liver and serum of Chinese ducks: integration of viral DNA in a hepatocellular carcinoma.

1985 • 72 citations

Molecular cloning of an oncogene from a human hepatocellular carcinoma.

1986 • 71 citations

Lymphoid cells in the spleens of woodchuck hepatitis virus-infected woodchucks are a site of active viral replication

1987 • 71 citations

Liver disease associated with duck hepatitis B virus infection of domestic ducks.

1984 • 69 citations

Trans-activation of HLA-DR gene by hepatitis B virus X gene product.

1990 • 69 citations

Assay of hepatitis B virus DNA by polymerase chain reaction and its relationship to Pre-S- and S-encoded viral surface antigens

1991 • 69 citations

Putative Reverse Transcriptase Intermediates of Human Hepatitis B Virus in Primary Liver Carcinomas

1986 • 69 citations

Identification of a region within the human immunodeficiency virus type 1 long terminal repeat that is essential for transactivation by the hepatitis B virus gene X

1989 • 68 citations

Detection and mapping of spliced RNA from a human hepatoma cell line transfected with the hepatitis B virus genome.

1989 • 67 citations

Tissue preferential expression of the hepatitis B virus (HBV) surface antigen gene in two lines of HBV transgenic mice

1988 • 67 citations

Hepatitis B virus suppresses expression of human beta-interferon.

1988 • 67 citations

MORTALITY OF HEPATITIS B POSITIVE BLOOD DONORS IN ENGLAND AND WALES

1985 • 67 citations

Cloned duck hepatitis B virus DNA is infectious in Pekin ducks

1984 • 66 citations

Identification of a promoter region for 3.6-kilobase mRNA of hepatitis B virus and specific cellular binding protein

1989 • 66 citations

Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.

1988 • 65 citations

The cloned genome of ground squirrel hepatitis virus is infectious in the animal.

1984 • 65 citations

A liver-specific nuclear factor interacts with the promoter region of the large surface protein gene of human hepatitis B virus.

1989 • 64 citations

Expression of hepatitis B viral core region in mammalian cells.

1986 • 63 citations

Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from a chronically infected liver

1984 • 61 citations

Structural relationships between the surface antigens of ground squirrel hepatitis virus and human hepatitis B virus

1980 • 60 citations

Amplification and rearrangement in hepatoma cell DNA associated with integrated hepatitis B virus DNA.

1984 • 60 citations

Complete nucleotide sequence of a molecular clone of woodchuck hepatitis virus that is infectious in the natural host.

1989 • 59 citations

Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma

1988 • 59 citations

Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host

1991 • 57 citations

A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin.

1985 • 57 citations

Hepatic fibrosis and cirrhosis after chronic administration of alcohol and “low-dose” carbon tetrachloride vapor in the rat

1991 • 57 citations

Regulation of the hepatitis B virus gene expression by the enhancer element I

1991 • 56 citations

Visualization of virus-like particles in endoplasmic reticulum of hepatocytes of Australia antigen carriers.

1972 • 56 citations

Hepatitis B virus DNA in children's liver diseases: detection by blot hybridisation in liver and serum.

1983 • 55 citations

The Biology of Hepadnaviruses

1986 • 55 citations

Oncogenes in human primary hepatic cancer

1986 • 54 citations

Expression of the c-Ha-ras and c-mye genes in aflatoxin B1-induced hepatocellular carcinomas

1986 • 54 citations

Hepatic fibrosis and cirrhosis after chronic administration of alcohol and “low-dose” carbon tetrachloride vapor in the rat

1991 • 54 citations

Transgenic mice containing hepatitis B virus sequences are more susceptible to carcinogen-induced hepatocarcinogenesis

1990 • 54 citations

Sequences of Hepatitis B Virus DNA in the Serum and Liver of Patients with Acute Benign and Fulminant Hepatitis

1987 • 53 citations

The S promoter of hepatitis B virus is regulated by positive and negative elements.

1988 • 53 citations

Hepatitis B virus particles of plasma and liver contain viral DNA-RNA hybrid molecules

1984 • 52 citations

Pregenomic RNA encapsidation analysis of eleven missense and nonsense polymerase mutants of human hepatitis B virus

1991 • 52 citations

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors

1988 • 52 citations

Diversity of hepatitis B virus X gene-related transcripts in hepatocellular carcinoma: a novel polyadenylation site on viral DNA

1991 • 51 citations

Integration of hepatitis B virus DNA in chromosome-specific satellite sequences

1986 • 51 citations

A fortuitously controlled study of steroid therapy in acute viral hepatitis

1969 • 51 citations

The genetic organization of integrated hepatitis B virus DNA in the human hepatoma cell line PLC/PRF/5

1984 • 51 citations

Sequence comparison of woodchuck hepatitis virus replicative forms shows conservation of the genome

1988 • 50 citations

Myristylation is involved in intracellular retention of hepatitis B virus envelope proteins

1991 • 50 citations

Distinctive properties of the hepatitis B virus envelope proteins

1988 • 49 citations

Systemic distribution of woodchuck hepatitis virus in the tissues of experimentally infected woodchucks

1988 • 48 citations

Different types of chronic hepatitis in alcoholic patients: Does chronic hepatitis induced by alcohol exist?

1991 • 48 citations

Defective response to interferons in cells transfected with the hepatitis B virus genome

1989 • 48 citations

Antigenic and structural relationships of the surface antigens of hepatitis B virus, ground squirrel hepatitis virus, and woodchuck hepatitis virus

1981 • 48 citations

A DNA element responsible for the different tissue specificities of Friend and Moloney retroviral enhancers

1988 • 47 citations

Point mutation, allelic loss and increased methylation of c-Ha-Ras gene in human hepatocellular carcinoma

1991 • 47 citations

Novel forms of woodchuck hepatitis virus DNA isolated from chronically infected woodchuck liver nuclei

1982 • 47 citations

The hepatitis B virus enhancer modulates transcription of the hepatitis B virus surface antigen gene from an internal location

1988 • 45 citations

Developmental regulation of hepatitis B surface antigen expression in two lines of hepatitis B virus transgenic mice

1989 • 45 citations

Ground Squirrel Hepatitis Virus Infection

2007 • 45 citations

Mechanism of translation of the hepadnaviral polymerase (P) gene.

1990 • 44 citations

Detection of hepatitis B virus X product using an open reading frame Escherichia coli expression vector.

1986 • 44 citations

Latency and reactivation of a precore mutant hepatitis B virus in a chronically infected patient

1990 • 44 citations

Experimental systems for the study of hepadnavirus and hepatitis delta virus infections

1989 • 44 citations

Hepadnaviruses and retroviruses share genome homology and features of replication

1987 • 43 citations

The surface gene promoter of the human hepatitis B virus displays a preference for differentiated hepatocytes

1989 • 43 citations

Hepatitis B e Antigen and Antibody Measured by Radioimmunoassay in Acute Hepatitis B Surface Antigen-Positive Hepatitis

1980 • 43 citations

Synthesis of the X-protein of hepatitis B virus in vitro and detection of anti-X antibodies in human sera

1987 • 43 citations

Production of infectious duck hepatitis B virus in a human hepatoma cell line

1988 • 42 citations

Hepatitis B virus (HBV) X gene expression in human cells and anti-HBx antibodies detection in chronic HBV infection

1990 • 42 citations

Novel RNA family structure of hepatitis B virus expressed in human cells, using a helper-free adenovirus vector

1986 • 42 citations

Chronic Hepatitis and Hepatocellular Carcinoma Associated with Persistent Woodchuck Hepatitis Virus Infection

1985 • 42 citations

Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular cloning

1982 • 41 citations

Fused transcripts of c-myc and a new cellular locus, hcr in a primary liver tumor.

1989 • 41 citations

Integration of Region X of Hepatitis B Virus Genome in Human Primary Hepatocellular Carcinomas Propagated in Nude Mice

1986 • 41 citations

Characterization of hepatitis B virus major surface antigen gene transcriptional regulatory elements in differentiated hepatoma cell lines

1989 • 41 citations

A newly identified hepatitis B type virus in tree squirrels.

1986 • 41 citations

Carcinogenesis and prevention strategy of liver cancer in areas of prevalence

1984 • 40 citations

Genomic localization of hepatitis B virus in a human hepatoma cell line

1986 • 40 citations

Co-transcribed 3′ host sequences augment expression of integrated hepatitis B virus DNA.

1985 • 38 citations

Sequence of a replication competent Hepatitis B virus genome with a preX open reading frame

1990 • 38 citations

Structure and expression of hcr, a locus rearranged with c-myc in a woodchuck hepatocellular carcinoma.

1989 • 38 citations

Significance of anti-HBx antibodies in hepatitis B virus infection

1991 • 37 citations

Microdeletion associated with the integration process of hepatitis B virus DNA

1988 • 37 citations

Production of hepatitis B virus nucleocapsidlike core particles in Xenopus oocytes: assembly occurs mainly in the cytoplasm and does not require the nucleus

1991 • 36 citations

Molecular aspects of persistent woodchuck hepatitis virus and hepatitis B virus infection and hepatocellular carcinoma

1987 • 36 citations

Core Particles of Hepatitis B Virus and Ground Squirrel Hepatitis Virus I. Relationship Between Hepatitis B Core Antigen- and Ground Squirrel Hepatitis Core Antigen-Associated Polypeptides by Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis and Tryptic Peptide Mapping

1982 • 36 citations

Integrated state of subgenomic fragments of hepatitis B virus DNA in hepatocellular carcinoma from mainland China.

1987 • 36 citations

The enhancer sequence of human hepatitis B virus can enhance the activity of its surface gene promoter

1987 • 36 citations

Sequence of events in natural infection of Pekin duck embryos with duck hepatitis B virus

1985 • 35 citations

Phenotypic patterns of preneoplastic and neoplastic hepatic lesions in woodchucks infected with woodchuck hepatitis virus

1990 • 35 citations

Evidence against a requisite role for defective virus in the establishment of persistent hepadnavirus infections.

1990 • 35 citations

The topoisomerase I inhibitor, camptothecin, inhibits equine infectious anemia virus replication in chronically infected CF2Th cells

1991 • 35 citations

Enzyme‐altered Liver Cell Foci in Woodchucks Infected with Woodchuck Hepatitis Virus

1988 • 34 citations

Duck hepatitis B virus replicates in the yolk sac of developing embryos

1987 • 34 citations

Antibodies in Anti-HBe—positive patient sera bind to an HBe protein expressed on the cell surface of human hepatoma cells: Implications for virus clearance

1991 • 34 citations

Biological characterization of acute infection with ground squirrel hepatitis virus

1982 • 34 citations

Expression of X protein and hepatitis B virus replication in chronic hepatitis

1991 • 33 citations

Ground squirrel hepatitis virus DNA: molecular cloning and comparison with hepatitis B virus DNA

1981 • 33 citations

Complex regulation of transcription from the hepatitis B virus major surface antigen promoter in human hepatoma cell lines

1991 • 33 citations

Mouse Monoclonal Antibody Directed against Hepatitis B Virus X Protein Synthesized in <i>Escherichia coli</i>: Detection of Reactive Antigen in Liver Cell Carcinoma and Chronic Hepatitis

1990 • 33 citations

Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum.

1989 • 32 citations

Influence of aflatoxin B1 intoxication on duck livers with duck hepatitis B virus infection.

1988 • 32 citations

Insertional activation of N-myc by endogenous Moloney-like murine retrovirus sequences in macrophage cell lines derived from myeloma cell line-macrophage hybrids.

1989 • 32 citations

Protection of chimpanzees from type B hepatitis by immunization with woodchuck hepatitis virus surface antigen

1986 • 32 citations

Hepatocellular carcinoma in Richardson's ground squirrels(Spermophilus richardsonii): Evidence for association with hepatitis B–like virus infection

1991 • 31 citations

In vitro recombinants of ground squirrel and woodchuck hepatitis viral DNAs produce infectious virus in squirrels

1987 • 31 citations

Extrahepatic replication of woodchuck hepatitis virus in chronic infection

1989 • 31 citations

Integration of hepatitis B virus: analysis of unoccupied sites

1987 • 31 citations

A recombinant Chinese hamster ovary cell line containing a 300-fold amplified tetramer of the hepatitis B genome together with a double selection marker expresses high levels of viral protein

1986 • 29 citations

Characteristics of the X gene of hepatitis B virus

1988 • 28 citations

Antibodies to pre-S and X determinants arise during natural infection with ground squirrel hepatitis virus

1986 • 27 citations

Regional assignment of the polymorphic probe D3S3 to 3p14 by molecular hybridization

1986 • 26 citations

The R-U5-5' leader sequence of neurovirulent wild mouse retrovirus contains an element controlling the incubation period of neurodegenerative disease

1991 • 26 citations

Negative regulation of the hepatitis B virus pre-S1 promoter by internal DNA sequences

1989 • 25 citations

Comparative sequence analysis of defective and infectious avian hepadnaviruses

1991 • 23 citations

Hepatitis B Virus DNA in Dane Particles: Evidence for the Presence of Replicative Intermediates

1985 • 23 citations

Epidemiology and erdication strategy for hepatitis B in Europe

1990 • 23 citations

Frequent integration of hepatitis B virus DNA in noncancerous liver tissue from hepatocellular carcinoma patients

1988 • 22 citations

Integration of hepatitis virus DNA near c-myc in woodchuck hepatocellular carcinoma

1990 • 22 citations

Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts

1985 • 22 citations

Free and integrated forms of hepatitis B virus DNA in human hepatocellular carcinoma cells (PLC/342) propagated in nude mice

1987 • 21 citations

Integrated structures of duck hepatitis B virus DNA in hepatocellular carcinoma

1988 • 21 citations

Involvement of an AFP1-binding site in cell-specific transcription of the pre-S1 region of the human hepatitis B virus surface antigen gene

1989 • 20 citations

Hepatitis B virus related hepatocellular carcinoma: chronicity of infection - the opening to different pathways of malignant transformation?

1990 • 20 citations

Nonoverlapping antigenic sites of woodchuck hepatitis virus surface antigen and their cross-reactivity with ground squirrel hepatitis virus and hepatitis B virus surface antigens

1983 • 20 citations

Ground squirrel hepatitis virus (GSHV) infection and hepatocellular carcinoma in the Canadian Richardson ground squirrel (Spermophilus richardsonii)

1986 • 20 citations

Natural history of experimental woodchuck hepatitis virus infection: molecular virologic features of the pancreas, kidney, ovary, and testis

1990 • 19 citations

Expression pattern of the hepatitis B virus genome in transfected mouse fibroblasts

1990 • 19 citations

Natural and experimental infection of wild mallard ducks with duck hepatitis B virus

1991 • 18 citations

N-myc activation by proviral insertion in MCF 247-induced murine T-cell lymphomas.

1989 • 18 citations

Morbidity and mortality from chronic hepatitis B virus infection in family members of patients with malignant and nonmalignant hepatitis B virus–related chronic liver diseases

1991 • 17 citations

Controlling hepatitis B virus transmission in North America

1990 • 15 citations

X gene-related sequences in the core gene of duck and heron hepatitis B viruses.

1988 • 15 citations

Identification of a strong enhancer element upstream from the pregenomic RNA start site of the duck hepatitis B virus genome

1991 • 15 citations

Detection of integration during active replication of hepatitis B virus in the liver

1985 • 15 citations

Frequent lymphocytes infection by hepatitis B virus in haemophiliacs

1987 • 14 citations

Frequent lymphocytes infection by hepatitis B virus in haemophiliacs

1987 • 9 citations

Vertical transmission of woodchuck hepatitis virus

1988 • 7 citations

Infection spontanée et expérimentale de la marmotte alpine (Marmota marmota) par le virus de l'hépatite de la marmotte nord-Américaine (Marmota monax) premiers résultats

1984 • 6 citations

Nucleotide sequence of the woodchuck hepatitis virus surface antigen mRNAs and the variability of three overlapping viral genes

1986 • 5 citations

The lca as an onco-fetal gene: its expression in human fetal liver.

1988 • 2 citations

Activation of the hepatocarcinogen aflatoxin B1 by forms of human hepatic cytochromes P-450: Some do and some don't

1991 • 2 citations