Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen.

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Intracellular protein topogenesis

1980 • 1,378 citations

The hepatitis B virus

1985 • 1,219 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

Large surface proteins of hepatitis B virus containing the pre-s sequence

1984 • 812 citations

Multiple Mechanisms of Protein Insertion into and Across Membranes

1985 • 720 citations

Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane

1986 • 509 citations

Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.

1980 • 502 citations

Biology of Hepatitis B Virus

1981 • 394 citations

Many Random Sequences Functionally Replace the Secretion Signal Sequence of Yeast Invertase

1987 • 375 citations

THE NUCLEOTIDE SEQUENCE OF THE HEPATITIS B VIRAL GENOME AND THE IDENTIFICATION OF THE MAJOR VIRAL GENES

1980 • 277 citations

Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants

1985 • 277 citations

Expression from cloned cDNA of cell-surface secreted forms of the glycoprotein of vesicular stomatitis virus in eucaryotic cells

1982 • 266 citations

Construction of influenza haemagglutinin genes that code for intracellular and secreted forms of the protein

1982 • 236 citations

An internal signal sequence: The asialoglycoprotein receptor membrane anchor

1986 • 209 citations

An artificial anchor domain: hydrophobicity suffices to stop transfer

1985 • 206 citations

Uncoupling Translocation from Translation: Implications for Transport of Proteins Across Membranes

1986 • 195 citations

Bovine opsin has more than one signal sequence

1985 • 186 citations

The human glucose transporter can insert posttranslationally into microsomes

1986 • 176 citations

Three recently described animal virus models for human hepatitis B virus

1981 • 175 citations

Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5.

1983 • 155 citations

Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus

1984 • 155 citations

Comparative sequence analysis of duck and human hepatitis B virus genomes

1985 • 153 citations

Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes.

1984 • 149 citations

Isolation and characterization of the major protein and glycoprotein of hepatitis B surface antigen.

1981 • 147 citations

The membrane-spanning segment of invariant chain (Iγ) contains a potentially cleavable signal sequence

1986 • 142 citations

Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide.

1986 • 142 citations

A stop transfer sequence confers predictable transmembrane orientation to a previously secreted protein in cell-free systems

1983 • 142 citations

Intracellular assembly and packaging of hepatitis B surface antigen particles occur in the endoplasmic reticulum

1986 • 121 citations

Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region

1983 • 113 citations

Australia Antigen (Hepatitis B Antigen): A Conformational Antigen Dependent on Disulfide Bonds

1972 • 106 citations

A cytosolic protein contains a cryptic mitochondrial targeting signal

1987 • 101 citations

A former amino terminal signal sequence engineered to an internal location directs translocation of both flanking protein domains.

1985 • 98 citations

Structure of hepatitis B surface antigen. Correlation of subtype with amino acid sequence and location of the carbohydrate moiety.

1982 • 91 citations

Foreign transmembrane peptides replacing the internal signal sequence of transferrin receptor allow its translocation and membrane binding

1987 • 75 citations

A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin.

1985 • 57 citations

A stop transfer sequence recognizes receptors for nascent chain translocation across the endoplasmic reticulum membrane

1986 • 54 citations

Direct Expression of Hepatitis B Surface Antigen in Monkey Cells from an SV40 Vector

1982 • 53 citations

Mechanism of protein translocation across the endoplasmic reticulum.

1982 • 35 citations

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