Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

1982 • 1,429 citations

The hepatitis B virus

1985 • 1,219 citations

Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis

1985 • 1,069 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

A new retinoic acid receptor identified from a hepatocellular carcinoma

1988 • 613 citations

Risk of Cirrhosis and Primary Liver Cancer in Alpha₁-Antitrypsin Deficiency

1986 • 582 citations

An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice.

1987 • 443 citations

Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma

1986 • 399 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State

1985 • 281 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

Activated Oncogenes in B6C3F1 Mouse Liver Tumors: Implications for Risk Assessment

1987 • 279 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Oncogene-induced liver neoplasia in transgenic mice.

1989 • 249 citations

Pancreatic Neoplasia Induced by SV40 T-Antigen Expression in Acinar Cells of Transgenic Mice

1987 • 243 citations

SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice

1985 • 241 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation

1987 • 202 citations

Deletion in Chromosome 11p Associated with a Hepatitis B Integration Site in Hepatocellular Carcinoma

1985 • 199 citations

Expression and replication of hepatitis B virus genome in transgenic mice.

1989 • 196 citations

Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma

1988 • 192 citations

Detection and identification of activated oncogenes in spontaneously occurring benign and malignant hepatocellular tumors of the B6C3F1 mouse.

1986 • 177 citations

A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state.

1988 • 174 citations

Liver Lesions in B6C3F1 Mice: The National Toxicology Program, Experience and Position

1987 • 159 citations

A morphologic classification of proliferative and neoplastic hepatic lesions in mice.

1979 • 159 citations

Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.

1986 • 155 citations

Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice

1985 • 150 citations

Specific Expression of Hepatitis B Surface Antigen (HBsAg) in Transgenic Mice

1985 • 149 citations

Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis.

1985 • 140 citations

Neonatal Hepatitis Induced by α ₁ -Antitrypsin: a Transgenic Mouse Model

1988 • 139 citations

Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks

1986 • 139 citations

Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome

1988 • 136 citations

Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice.

1987 • 135 citations

Synthesis and encapsidation of duck hepatitis B virus reverse transcriptase do not require formation of core-polymerase fusion proteins

1989 • 132 citations

Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children

1987 • 118 citations

Hepatocellular carcinoma in type I glycogen storage disease

1988 • 115 citations

Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas

1987 • 113 citations

Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line

1985 • 113 citations

Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site.

1985 • 112 citations

Electron microscopy and immunoelectronmicroscopy of cytoplasmic hepatitis B antigen in hepatocytes.

1974 • 110 citations

Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC/PRF/5.

1983 • 98 citations

c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet.

1989 • 95 citations

Chronic ‘Cryptogenic’ Liver Disease and Malignant Hepatoma in Intermediate Alpha_rAntitrypsin Deficiency Identified by a Pi Z-Specific Monoclonal Antibody

1985 • 90 citations

The rapid induction of liver cell death in rats fed a choline-deficient methionine-low diet.

1983 • 90 citations

Skin Carcinogenesis. Mechanisms and Human Relevance.

1989 • 90 citations

Hepatitis B virus structure and biology

1989 • 88 citations

Inversely repeating integrated hepatitis B virus DNA and cellular flanking sequences in the human hepatoma-derived cell line huSP.

1985 • 86 citations

Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region

1987 • 86 citations

Spontaneous tumors in control F344 and Charles River-CD rats and Charles River CD-1 and B6C3HF1 mice

1982 • 85 citations

Cellular Events During Hepatocarcinogenesis In Rats And The Question Of Premalignancy

1987 • 85 citations

Hepatocellular carcinoma in primary biliary cirrhosis: Detection by α-fetoprotein estimation

1984 • 82 citations

Regeneration and the mechanism of epidermal tumor promotion

1985 • 80 citations

T antigen expression and tumorigenesis in transgenic mice containing a mouse major urinary protein/SV40 T antigen hybrid gene.

1989 • 77 citations

Cloning and analysis of integrated hepatitis virus sequences from a human hepatoma cell line

1984 • 75 citations

Molecular cloning of an oncogene from a human hepatocellular carcinoma.

1986 • 71 citations

Activation of ras oncogene in aflatoxin-induced rat liver carcinogenesis.

1988 • 71 citations

Tissue preferential expression of the hepatitis B virus (HBV) surface antigen gene in two lines of HBV transgenic mice

1988 • 67 citations

Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma

1988 • 59 citations

Rat α-fetoprotein—III. Refinement of radioimmunoassay for detection of 1 ng rat α1F

1973 • 56 citations

Visualization of virus-like particles in endoplasmic reticulum of hepatocytes of Australia antigen carriers.

1972 • 56 citations

Background Data and Variations in Tumor Rates of Control Rats and Mice

2015 • 52 citations

Developmental regulation of hepatitis B surface antigen expression in two lines of hepatitis B virus transgenic mice

1989 • 45 citations

Experimental systems for the study of hepadnavirus and hepatitis delta virus infections

1989 • 44 citations

Activated N-ras gene was found in human hepatoma tissue but only in a small fraction of the tumor cells.

1989 • 42 citations

Molecular aspects of persistent woodchuck hepatitis virus and hepatitis B virus infection and hepatocellular carcinoma

1987 • 36 citations

A lack of direct role of hepatitis B virus in the activation of ras and c-myc oncogenes in human hepatocellular carcinogenesis

1988 • 31 citations

Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouse

1989 • 25 citations

Serum alpha-fetoprotein in a mouse strain (C3H-Avy fB) with spontaneous hepatocellular carcinomas.

1977 • 20 citations

Methylation of hepatitis B virus DNA and liver-specific suppression of RNA production in transgenic mouse.

1987 • 16 citations

Epidermal tumor promotion by damage in the skin of mice.

1989 • 13 citations

Over expression of proto-oncogenes: ki-ras, fos and myc in rat liver cells treated in vitro by two liver tumor promoters: phenobarbital and biliverdin

1989 • 13 citations

Organization and expression of hepatitis B sequences cloned from hepatocellular carcinoma tissue DNA

1982 • 9 citations