Therapeutic Potential of 4-1BB (CD137) As a Regulator for Effector CD8⁺T Cells

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

2001 • 1,538 citations

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 • 1,391 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

2001 • 937 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Dendritic Cells in Cancer Immunotherapy

2000 • 698 citations

Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells

1999 • 580 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Dendritic Cell Vaccines for Cancer Immunotherapy

1999 • 497 citations

CD28- T lymphocytes. Antigenic and functional properties.

1993 • 403 citations

Differentiation of Naive CTL to Effector and Memory CTL: Correlation of Effector Function with Phenotype and Cell Division

1998 • 379 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells.

1999 • 379 citations

NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies

1998 • 361 citations

CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1

1998 • 358 citations

Expansion of cytotoxic CD8⁺ CD28⁻ T cells in healthy ageing people, including centenarians

1996 • 355 citations

On guard—activating NK cell receptors

2001 • 350 citations

T cell co-stimulatory molecules other than CD28

1999 • 349 citations

IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men

1999 • 333 citations

Costimulation of CD28- T lymphocytes by 4-1BB ligand.

1997 • 333 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

1999 • 320 citations

TGF-β1 Prevents the Noncognate Maturation of Human Dendritic Langerhans Cells

1999 • 303 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus

1999 • 280 citations

Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+ T Cells Closely Correlates with CD56 Surface Expression

2000 • 263 citations

4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses

1999 • 259 citations

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death.

1997 • 256 citations

NK Markers Are Expressed on a High Percentage of Virus-Specific CD8+ and CD4+ T Cells

2000 • 250 citations

Disruption of T Cell Homeostasis in Mice Expressing a T Cell–Specific Dominant Negative Transforming Growth Factor β II Receptor

2000 • 248 citations

Moslecular and biological characterization of human 4‐1BB and its ligands

1994 • 242 citations

4‐1BB T‐cell antigen binds to mature B cells and macrophages, and costimulates anti‐μ‐primed splenic B cells

1994 • 223 citations

Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway

1998 • 218 citations

Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes.

1993 • 214 citations

Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+CD28– cytotoxic effector clones

1999 • 211 citations

TGF-β1 regulation of dendritic cells

1999 • 205 citations

In Vivo Expression of Natural Killer Cell Inhibitory Receptors by Human Melanoma–Specific Cytolytic T Lymphocytes

1999 • 202 citations

Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.

1998 • 198 citations

Faces and phases of human CD8+ T-cell development

1999 • 187 citations

Studies Using Antigen-Presenting Cells Lacking Expression of Both B7-1 (CD80) and B7-2 (CD86) Show Distinct Requirements for B7 Molecules During Priming Versus Restimulation of Th2 But Not Th1 Cytokine Production

1998 • 175 citations

Immune privilege or inflammation? Insights into the Fas ligand enigma

2001 • 159 citations

Postthymic Development of CD28−CD8+ T Cell Subset: Age-Associated Expansion and Shift from Memory to Naive Phenotype

1999 • 156 citations

The effect of TGF-β1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells

2000 • 154 citations

CD40-CD40 Ligand Costimulation Is Required for Generating Antiviral CD4 T Cell Responses But Is Dispensable for CD8 T Cell Responses

1999 • 153 citations

Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms

1999 • 152 citations

Costimulation in antiviral immunity: differential requirements for CD4+ and CD8+ T cell responses

2000 • 148 citations

Ligation of 4-1BB (CDw137) Regulates Graft-Versus-Host Disease, Graft-Versus-Leukemia, and Graft Rejection in Allogeneic Bone Marrow Transplant Recipients

2001 • 147 citations

CD8+ T Cells Rapidly Acquire NK1.1 and NK Cell-Associated Molecules Upon Stimulation In Vitro and In Vivo

2000 • 147 citations

4-1BB Costimulation Is Required for Protective Anti-Viral Immunity After Peptide Vaccination

2000 • 143 citations

Loss of CD28 expression on CD8+ T cells is induced by IL-2 receptor γ chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis

2000 • 141 citations

Adjuvant Effect of IL-12: Conversion of Peptide Antigen Administration from Tolerizing to Immunizing for CD8+ T Cells In Vivo

1999 • 138 citations

A Shift in the Phenotype of Melan-A-Specific CTL Identifies Melanoma Patients with an Active Tumor-Specific Immune Response

2000 • 138 citations

Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses

1998 • 131 citations

4-1BBL Cooperates with B7-1 and B7-2 in Converting a B Cell Lymphoma Cell Line into a Long-Lasting Antitumor Vaccine

1999 • 130 citations

Large clonal expansions of human virus‐specific memory cytotoxic T lymphocytes within the CD57⁺ CD28^– CD8⁺ T‐cell population

1999 • 127 citations

TGF-beta inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes.

1998 • 124 citations

CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients

1999 • 124 citations

IL-12 Enhances CD8 T Cell Homeostatic Expansion

2001 • 121 citations

Immunomodulatory Gene Therapy With Interleukin 12 and 4-1BB Ligand: Long- Term Remission of Liver Metastases in a Mouse Model

2000 • 120 citations

CD40 Ligand-Mediated Interactions Are Involved in the Generation of Memory CD8⁺Cytotoxic T Lymphocytes (CTL) but Are Not Required for the Maintenance of CTL Memory following Virus Infection

1998 • 120 citations

Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells.

1998 • 117 citations

IFN-gamma and CD8+ T cells restore host defenses against Pneumocystis carinii in mice depleted of CD4+ T cells.

1999 • 116 citations

Emergence of CD8+ T Cells Expressing NK Cell Receptors in Influenza A Virus-Infected Mice

2000 • 112 citations

TGF-β Inhibits IL-12-Induced Activation of Jak-STAT Pathway in T Lymphocytes

1998 • 107 citations

Dendritic Cells Generated Either from CD34+ Progenitor Cells or from Monocytes Differ in Their Ability to Activate Antigen-Specific CD8+ T Cells

1999 • 106 citations

IFN-γ and CD8+ T Cells Restore Host Defenses AgainstPneumocystis cariniiin Mice Depleted of CD4+ T Cells

1999 • 106 citations

Low Dose TGF-β Attenuates IL-12 Responsiveness in Murine Th Cells

1998 • 96 citations

Functionally distinct CD8+ memory T cell subsets in persistent EBV infection are differentiated by migratory receptor expression

2000 • 95 citations

Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40

2000 • 93 citations

Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation.

2001 • 92 citations

Rejection of Disseminated Metastases of Colon Carcinoma by Synergism of IL-12 Gene Therapy and 4-1BB Costimulation

2000 • 88 citations

Cord blood T lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes

1995 • 88 citations

Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses

2001 • 88 citations

Host T Cells Resist Graft-Versus-Host Disease Mediated by Donor Leukocyte Infusions

2000 • 80 citations

Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines.

1995 • 78 citations

Cytolytic Mechanisms and Expression of Activation-Regulating Receptors on Effector-Type CD8+CD45RA+CD27− Human T Cells

2000 • 77 citations

Phenotypic characterization of CD8+NKT cells

2000 • 75 citations

Therapeutic Vaccination for Cancer

2000 • 74 citations

Recognition of tumor cells by the innate immune system

2001 • 71 citations

Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).

1999 • 68 citations

Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12

1999 • 68 citations

Characterization of a novel subset of CD8(+) T cells that expands in patients receiving interleukin-12.

1998 • 65 citations

Vaccines With Interleukin-12–Transduced Acute Myeloid Leukemia Cells Elicit Very Potent Therapeutic and Long-Lasting Protective Immunity

1999 • 64 citations

Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses.

2000 • 62 citations

Dendritic cells and immunotherapy for malignant disease

2001 • 61 citations

Tumour rejection by gene transfer of 4-1BB ligand into a CD80+ murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells

2000 • 59 citations

In vivo tracking of tumor-specific T cells

2001 • 59 citations

The use of dendritic cells for cancer vaccination.

1999 • 58 citations

Developmental regulation of dendritic cell function

1999 • 57 citations

Peripheral human CD8+CD28+T lymphocytes give rise to CD28–progeny, but IL-4 prevents loss of CD28 expression

1999 • 53 citations

Vaccines With Interleukin-12–Transduced Acute Myeloid Leukemia Cells Elicit Very Potent Therapeutic and Long-Lasting Protective Immunity

1999 • 46 citations

Antigen-Independent Th2 Cell Differentiation by Stimulation of CD28: Regulation Via IL-4 Gene Expression and Mitogen-Activated Protein Kinase Activation

2001 • 44 citations

Relative Diabetogenic Properties of Islet-Specific Tc1 and Tc2 Cells in Immunocompetent Hosts

2000 • 41 citations

Enhanced Cytotoxic T Cell Activity in IL-4-Deficient Mice

1999 • 40 citations

Immune deviation and Fas-mediated deletion limit antitumor activity after multiple dendritic cell vaccinations in mice.

2000 • 39 citations

Cytokine-deficient CD8+ Tc1 cells induced by IL-4: retained inflammation and perforin and Fas cytotoxicity but compromised long term killing of tumor cells.

1997 • 29 citations

4-1BB Costimulation Promotes Human T Cell Adhesion to Fibronectin

1999 • 21 citations

CD80 Costimulation Is Required for Th2 Cell Cytokine Production But Not for Antigen-Specific Accumulation and Migration into the Lung

2001 • 21 citations

Expression of Co-stimulatory 4-1BB Ligand Induces Significant Tumor Regression and Protective Immunity

1999 • 15 citations

CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients

1999 • 6 citations

The effect of TGF-β1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells

2000 • 5 citations