Cytolytic Mechanisms and Expression of Activation-Regulating Receptors on Effector-Type CD8+CD45RA+CD27− Human T Cells

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

NK CELL RECEPTORS

1998 • 1,666 citations

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 • 1,391 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

1994 • 788 citations

Characterization of an Antigen That Is Recognized on a Melanoma Showing Partial HLA Loss by CTL Expressing an NK Inhibitory Receptor

1997 • 746 citations

Telomere Fluorescence Measurements in Granulocytes and T Lymphocyte Subsets Point to a High Turnover of Hematopoietic Stem Cells and Memory T Cells in Early Childhood

1999 • 719 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

The CTL's kiss of death

1995 • 504 citations

Quantitative analysis of hepatitis C virus-specific CD8⁺T cells in peripheral blood and liver using peptide-MHC tetramers

1999 • 421 citations

CD28- T lymphocytes. Antigenic and functional properties.

1993 • 403 citations

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

1996 • 401 citations

How do cytotoxic lymphocytes kill their targets?

1998 • 398 citations

Expansion of cytotoxic CD8⁺ CD28⁻ T cells in healthy ageing people, including centenarians

1996 • 355 citations

Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.

1998 • 336 citations

Superantigen-Dependent, Cell-Mediated Cytotoxicity Inhibited by MHC Class I Receptors on T Lymphocytes

1995 • 316 citations

Modelling T-cell memory by genetic marking of memory T cells in vivo

1999 • 310 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation

1988 • 281 citations

Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts.

1996 • 259 citations

Benign Monoclonal Gammapathy

1984 • 249 citations

Human CD8+ T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations.

1996 • 249 citations

Extracellular Granzymes A and B in Humans: Detection of Native Species During CTL Responses In Vitro and In Vivo

1998 • 193 citations

Evidence that human CD8+CD45RA+CD27– cells are induced by antigen and evolve through extensive rounds of division

1999 • 190 citations

Faces and phases of human CD8+ T-cell development

1999 • 187 citations

Interleukin‐15‐induced maturation of human natural killer cells from early thymic precursors: selective expression of CD94/NKG2‐A as the only HLA class I‐specific inhibitory receptor

1997 • 162 citations

Killer cell inhibitory receptors for MHC class I molecules regulate lysis of melanoma cells mediated by NK cells, gamma delta T cells, and antigen-specific CTL.

1998 • 157 citations

Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms

1999 • 152 citations

Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis

1997 • 143 citations

Human gamma interferon and tumor necrosis factor exert a synergistic blockade on the replication of herpes simplex virus

1989 • 126 citations

CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients

1999 • 124 citations

Killer Cell Inhibitory Receptors for MHC Class I Molecules Regulate Lysis of Melanoma Cells Mediated by NK cells, γδ T Cells, and Antigen-Specific CTL

1998 • 121 citations

Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation.

1991 • 118 citations

Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis.

1997 • 114 citations

Subsets of CD8+, CD57+ cells in normal, healthy individuals: correlations with human cytomegalovirus (HCMV) carrier status, phenotypic and functional analyses

1993 • 111 citations

Changes in the Composition of Circulating CD8⁺T Cell Subsets during Acute Epstein‐Barr and Human Immunodeficiency Virus Infections in Humans

2000 • 105 citations

Age‐related accumulation of LFA‐1^high cells in a CD8⁺CD45RA^high T cell population

1993 • 101 citations

HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression.

1996 • 91 citations

T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.

1997 • 59 citations

Dissection of Pathways Leading to Antigen Receptor-Induced and Fas/CD95-Induced Apoptosis in Human B Cells

1998 • 48 citations

The new numerology of immunity mediated by virus-specific CD8+ T cells

1998 • 21 citations

Generation of alloreactive cytolytic T lymphocytes by immobilized anti-CD3 monoclonal antibodies. Analysis of requirements for human cytolytic T-lymphocyte differentiation.

1990 • 20 citations

Stimulatory Receptors in NK and T Cells

1998 • 17 citations