Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

A rapid method for the isolation of functional thymus‐derived murine lymphocytes

1973 • 4,203 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

Cytokine-induced survival of activated T cellsin vitroandin vivo

1998 • 395 citations

cDNA sequences of two inducible T-cell genes.

1989 • 392 citations

Costimulation of CD28- T lymphocytes by 4-1BB ligand.

1997 • 333 citations

Clonal expansion precedes anergy and death of V_β8⁺ peripheral T cells responding to staphylococcal enterotoxin B in vivo

1991 • 330 citations

Role of 4-1BB in immune responses

1998 • 312 citations

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death.

1997 • 256 citations

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen.

1993 • 241 citations

Lipopolysaccharide interferes with the induction of peripheral T cell death

1995 • 240 citations

Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses

1995 • 225 citations

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

1996 • 196 citations

T‐Cell Unresponsiveness in vivo and in vitro: Fine Specificity of Induction and Molecular Characterization of the Unresponsive State

1987 • 190 citations

CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.

1997 • 148 citations

CD40 Activation Boosts T Cell Immunity In Vivo by Enhancing T Cell Clonal Expansion and Delaying Peripheral T Cell Deletion

1999 • 83 citations

Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen.

1996 • 82 citations

Response of mature unprimed CD8+ T cells to Mlsa determinants.

1990 • 47 citations