Ligation of 4-1BB (CDw137) Regulates Graft-Versus-Host Disease, Graft-Versus-Leukemia, and Graft Rejection in Allogeneic Bone Marrow Transplant Recipients

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.

1997 • 1,290 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

The JAM test A simple assay for DNA fragmentation and cell death

1991 • 632 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Inducible T cell antigen 4-1BB. Analysis of expression and function.

1993 • 416 citations

cDNA sequences of two inducible T-cell genes.

1989 • 392 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies

1998 • 361 citations

Costimulation of CD28- T lymphocytes by 4-1BB ligand.

1997 • 333 citations

Molecular cloning of a ligand for the inducible T cell gene 4‐1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor

1993 • 328 citations

CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand

1998 • 321 citations

Role of 4-1BB in immune responses

1998 • 312 citations

Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus

1999 • 280 citations

4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses

1999 • 259 citations

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death.

1997 • 256 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 245 citations

Moslecular and biological characterization of human 4‐1BB and its ligands

1994 • 242 citations

4‐1BB T‐cell antigen binds to mature B cells and macrophages, and costimulates anti‐μ‐primed splenic B cells

1994 • 223 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 205 citations

Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy

1999 • 184 citations

Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28.

1995 • 181 citations

Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP.

1995 • 178 citations

CD40-CD40 Ligand Costimulation Is Required for Generating Antiviral CD4 T Cell Responses But Is Dispensable for CD8 T Cell Responses

1999 • 153 citations

Delayed infusion of immunocompetent donor cells after bone marrow transplantation breaks graft-host tolerance allows for persistent antileukemic reactivity without severe graft-versus-host disease

1995 • 137 citations

Recent advances in graft‐versus‐host disease (GVHD) prevention

1997 • 134 citations

Opposing Roles of CD28:B7 and CTLA-4:B7 Pathways in Regulating In Vivo Alloresponses in Murine Recipients of MHC Disparate T Cells

1999 • 127 citations

CTLA4Ig TREATMENT AMELIORATES THE LETHALITY OF MURINE GRAFT-VERSUS-HOST DISEASE ACROSS MAJOR HISTOCOMPATIBILITY COMPLEX BARRIERS

1994 • 123 citations

Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.

1996 • 120 citations

Co-stimulation of antigen-specific CD4 T cells by 4-1BB ligand

2000 • 120 citations

Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts

1995 • 119 citations

Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD) development: CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD.

1996 • 91 citations

CD4+ AND CD8+ T CELLS EACH CAN UTILIZE A PERFORIN-DEPENDENT PATHWAY TO MEDIATE LETHAL GRAFT-VERSUS-HOST DISEASE IN MAJOR HISTOCOMPATIBILITY COMPLEX-DISPARATE RECIPIENTS1

1997 • 90 citations

Involvement of CD40 Ligand-CD40 and CTLA4-B7 Pathways in Murine Acute Graft-Versus-Host Disease Induced by Allogeneic T Cells Lacking CD28

1998 • 88 citations

CD28/B7 interactions are required for sustaining the graft-versus-leukemia effect of delayed post-bone marrow transplantation splenocyte infusion in murine recipients of myeloid or lymphoid leukemia cells.

1997 • 81 citations

Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells.

1997 • 79 citations

New strategies for preventing graft-versus-host disease

1999 • 79 citations

Role of CD28 in Acute Graft-Versus-Host Disease

1998 • 75 citations

The role of cytokines in acute graft-versus-host disease.

1997 • 70 citations

Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses.

2000 • 62 citations

Profound atrophy of the bone marrow reflecting major histocompatibility complex class II-restricted destruction of stem cells by CD4+ cells.

1994 • 60 citations

Dysregulation of Cytokines During Graft-Versus-Host Disease

1996 • 56 citations

THE ROLE OF HOST T CELL SUBSETS IN BONE MARROW REJECTION DIRECTED TO ISOLATED MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I VERSUS CLASS II DIFFERENCES OF bm1 and bm12 MUTANT MICE1,2

1994 • 51 citations

Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules.

1995 • 46 citations

ACUTE GRAFT-VERSUS-HOST DISEASE WITHOUT COSTIMULATION VIA CD281

1997 • 37 citations

The role of T cell subsets in regulating the in vivo efficacy of CTLA4-Ig in preventing graft-versus-host disease in recipients of fully MHC or multiple minor histocompatibility-disparate donor inocula.

1994 • 22 citations