Ligand-targeted liposomal anticancer drugs

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell Lymphoma

2002 • 5,269 citations

Diffusion of univalent ions across the lamellae of swollen phospholipids

1965 • 4,347 citations

Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.

1998 • 2,777 citations

Ligand-targeted therapeutics in anticancer therapy

2002 • 1,592 citations

Making Antibodies by Phage Display Technology

1994 • 1,516 citations

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

1988 • 1,103 citations

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

1998 • 1,013 citations

Folate-mediated delivery of macromolecular anticancer therapeutic agents

2002 • 911 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Treatment of Patients With Low-Grade B-Cell Lymphoma With the Combination of Chimeric Anti-CD20 Monoclonal Antibody and CHOP Chemotherapy

1999 • 878 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Improving the efficacy of antibody-based cancer therapies

2001 • 821 citations

Large unilamellar liposomes with low uptake into the reticuloendothelial system

1987 • 718 citations

Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery.

2002 • 638 citations

Pegylated liposomal doxorubicin (doxil): Reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2

2000 • 593 citations

Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro

1995 • 569 citations

Pharmacokinetics of stealth versus conventional liposomes: effect of dose

1991 • 566 citations

Therapeutic antibodies for human diseases at the dawn of the twenty-first century

2002 • 540 citations

Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target

1991 • 478 citations

Current status of pH-sensitive liposomes in drug delivery

2000 • 467 citations

Targeting Folate Receptor with Folate Linked to Extremities of Poly(ethylene glycol)-Grafted Liposomes: In Vitro Studies

1999 • 461 citations

Long-circulating (sterically stabilized) liposomes for targeted drug delivery

1994 • 449 citations

Sterically Stabilized Anti-HER2 Immunoliposomes: Design and Targeting to Human Breast Cancer Cells in Vitro

1997 • 438 citations

Human immune response to multiple injections of murine monoclonal IgG.

1985 • 425 citations

Chimeric Anti-CD20 (IDEC-C2B8) Monoclonal Antibody Sensitizes a B Cell Lymphoma Cell Line to Cell Killing by Cytotoxic Drugs

1997 • 411 citations

Endocytosis of liposomes and intracellular fate of encapsulated molecules: Encounter with a low pH compartment after internalization in coated vesicles

1983 • 394 citations

Doxorubicin Encapsulated in Liposomes Containing Surface‐Bound Polyethylene Glycol: Pharmacokinetics, Tumor Localization, and Safety in Patients with AIDS‐Related Kaposi's Sarcoma

1996 • 370 citations

Irreversible coupling of immunoglobulin fragments to preformed vesicles. An improved method for liposome targeting.

1982 • 331 citations

Tumor targeting using anti-her2 immunoliposomes

2001 • 331 citations

Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells.

2001 • 328 citations

Attachment of antibodies to sterically stabilized liposomes: evaluation, comparison and optimization of coupling procedures

1995 • 312 citations

Molecular mechanism of the lipid vesicle longevity in vivo

1993 • 305 citations

Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice.

1992 • 303 citations

Oncotic pressure in solid tumors is elevated.

2000 • 293 citations

Pharmacokinetics of long-circulating liposomes

1995 • 288 citations

A new strategy for attachment of antibodies to sterically stabilized liposomes resulting in efficient targeting to cancer cells

1995 • 286 citations

Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs

1999 • 273 citations

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

1994 • 272 citations

High-avidity human IgGκ monoclonal antibodies from a novel strain of minilocus transgenic mice

1996 • 271 citations

p-Nitrophenylcarbonyl-PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups

2001 • 269 citations

Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol) s conjugated at their distal terminals to monoclonal antibodies

1995 • 262 citations

In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma.

1998 • 260 citations

Development of anti-p185HER2 immunoliposomes for cancer therapy.

1995 • 258 citations

Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors in vivo.

2001 • 251 citations

Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs.

2002 • 244 citations

Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice.

1993 • 239 citations

Translocation of Liposomes into Cancer Cells by Cell-Penetrating Peptides Penetratin and Tat: A Kinetic and Efficacy Study

2002 • 236 citations

A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs

1999 • 232 citations

The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer.

1996 • 221 citations

In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniques with those made by a new post-insertion approach

2001 • 217 citations

Intracellular targeting therapy of cisplatin‐encapsulated transferrin‐polyethylene glycol liposome on peritoneal dissemination of gastric cancer

2002 • 215 citations

Immunospecific targeting of liposomes to cells: a novel and efficient method for covalent attachment of Fab' fragments via disulfide bonds

1981 • 214 citations

Possibility of active targeting to tumor tissues with liposomes

1999 • 211 citations

Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells

2001 • 208 citations

Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface‐grafted poly(ethylene glycol)

1996 • 203 citations

Immunogenicity and pharmacokinetic attributes of poly(ethylene glycol)-grafted immunoliposomes

1997 • 199 citations

Ammonium Sulfate Gradients for Efficient and Stable Remote Loading of Amphipathic Weak Bases into Liposomes and Ligandoliposomes.

1994 • 195 citations

Strategy for the treatment of acute myelogenous leukemia based on folate receptor β–targeted liposomal doxorubicin combined with receptor induction using all-trans retinoic acid

2002 • 194 citations

Selection of tumor-specific internalizing human antibodies from phage libraries

2000 • 190 citations

Folate targeting of haptens to cancer cell surfaces mediates immunotherapy of syngeneic murine tumors

2002 • 182 citations

Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro and in vivo studies

1996 • 179 citations

Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis

2002 • 178 citations

Vascular endothelial growth factor as a marker of tumor endothelium.

1998 • 168 citations

Immunoliposomes bearing polyethyleneglycol‐coupled Fab′ fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo

1997 • 168 citations

Immunoliposomes for the targeted delivery of antitumor drugs

1999 • 162 citations

Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding activity and cytotoxicity.

2002 • 153 citations

Doxorubicin-loaded Fab' fragments of anti-disialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice.

2003 • 148 citations

Monoclonal Circulating B Cells in Multiple Myeloma

1992 • 148 citations

Interactions of immunoliposomes with target cells.

1983 • 146 citations

pH-sensitive immunoliposomes as an efficient and target-specific carrier for antitumor drugs.

1986 • 145 citations

Imporved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide

1994 • 144 citations

Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes

1993 • 137 citations

Long Circulating Liposomes: Old Drugs, New Therapeutics

1998 • 133 citations

Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors.

1994 • 125 citations

Therapeutic opportunities for targeted liposomal drug delivery

1996 • 125 citations

By-passing of P-glycoprotein Using Immunoliposomes

2002 • 123 citations

Anti-HER2 immunoliposomes for targeted therapy of human tumors

1997 • 122 citations

Targeted drug delivery to C6 glioma by transferrin-coupled liposomes

2000 • 121 citations

CD34+ Cells in the Blood of Patients With Multiple Myeloma Express CD19 and IgH mRNA and Have Patient-Specific IgH VDJ Gene Rearrangements

1997 • 118 citations

Anti-neovascular therapy using novel peptides homing to angiogenic vessels

2002 • 116 citations

Immunoliposomes for Cancer Treatment

1997 • 116 citations

Targetability of novel immunoliposomes prepared by a new antibody conjugation technique

1999 • 115 citations

Characterization of In Vivo Immunoliposome Targeting to Pulmonary Endothelium

1990 • 112 citations

Novel pH-sensitive liposomes: liposomes bearing a poly(ethylene glycol) derivative with carboxyl groups

1994 • 106 citations

Liposomes : rational design

1999 • 105 citations

Investigation of the cellular uptake of E-Selectin-targeted immunoliposomes by activated human endothelial cells

2001 • 105 citations

Immune clearance of liposomes inhibited by an anti-Fc receptor antibody in vivo.

1986 • 101 citations

Uptake and processing of immunoglobulin-coated liposomes by subpopulations of rat liver macrophages

1988 • 98 citations

In vitro characterization of a novel polymeric-based pH-sensitive liposome system

2000 • 96 citations

Targeting Stealth liposomes in a murine model of human small cell lung cancer

2001 • 93 citations

Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice.

2000 • 92 citations

Peptide-Mediated Release of Folate-Targeted Liposome Contents from Endosomal Compartments¹

1996 • 91 citations

Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest

1994 • 90 citations

Antibody-Mediated Targeting of Long-Circulating (Stealth^R) Liposomes

1994 • 87 citations

Anti-MUC-1 immunoliposomal doxorubicin in the treatment of murine models of metastatic breast cancer

2001 • 81 citations

Cytotoxic targeting of F9 teratocarcinoma tumours with anti-ED-B fibronectin scFv antibody modified liposomes

2002 • 79 citations

Immunoliposome-mediated targeting of doxorubicin to human ovarian carcinoma in vitro and in vivo

1996 • 77 citations

Receptor-Specific Delivery of Liposomes Via Folate-Peg-Chol

2000 • 76 citations

Selective transfer of a lipophilic prodrug of 5-fluorodeoxyuridine from immunoliposomes to colon cancer cells

1999 • 76 citations

Folate receptor targeted delivery of liposomal daunorubicin into tumor cells.

2002 • 74 citations

Vascular endothelial growth factor and vascular targeting of solid tumors.

2002 • 74 citations

Targeting efficiency of PEG-immunoliposome-conjugated antibodies at PEG terminals

1997 • 72 citations

Cellular Trafficking and Cytotoxicity of Anti-Cd19-Targeted Liposomal Doxorubicin in B Lymphoma Cells

1999 • 71 citations

Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest

1994 • 65 citations

Internalizing antibodies and targeted cancer therapy: direct selection from phage display libraries

2000 • 62 citations

Liposome targeting to tumors using vitamin and growth factor receptors

2000 • 61 citations

ADVENTURES IN TARGETING

2002 • 59 citations

Immunoliposome-mediated targeting of anti-cancer drugs in vivo

1995 • 59 citations

Targeting of anti-Thy 1.1 monoclonal antibody conjugated liposomes in Thy 1.1 mice after intraveneous administration

1987 • 58 citations

Sterically stabilized anti-idiotype immunoliposomes improve the therapeutic efficacy of doxorubicin in a murine B-cell lymphoma model

1999 • 57 citations

Selective targeting of immunoliposomal doxorubicin against human multiple myeloma in vitro and ex vivo

2000 • 56 citations

VIP receptors as molecular targets of breast cancer: implications for targeted imaging and drug delivery

2001 • 56 citations

Systemic therapy with 3BIT, a triple combination cocktail of anti-CD19, -CD22, and -CD38-saporin immunotoxins, is curative of human B-cell lymphoma in severe combined immunodeficient mice.

1997 • 49 citations

pH-Induced destabilization of lipid bilayers by a lipopeptide derived from influenza hemagglutinin

1997 • 48 citations

Intrinsic Expression of the Multidrug Transporter, P-Glycoprotein 170, in Multiple Myeloma: Implications for Treatment

1995 • 47 citations

Possibility of the reversal of multidrug resistance and the avoidance of side effects by liposomes modified with MRK-16, a monoclonal antibody to P-glycoprotein

2001 • 47 citations

A growth factor antagonist as a targeting agent for sterically stabilized liposomes in human small cell lung cancer

2001 • 46 citations

Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro.

2001 • 46 citations

In Vivo Targeting by Liposomes.

2000 • 44 citations

Chronic Lymphocytic Leukemia with an Interfollicular Architecture: Avoiding Diagnostic Confusion with Monocytoid B-cell Lymphoma

1995 • 42 citations

CORRELATIONS BETWEEN THE RATE OF INTRACELLULAR RELEASE OF ENDOCYTOSED LIPOSOMAL DOXORUBICIN AND CYTOTOXICITY AS DETERMINED BY A NEW ASSAY

2001 • 39 citations

Pharmacokinetics of differently designed immunoliposome formulations in rats with or without hepatic colon cancer metastases.

2001 • 38 citations

Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells

1999 • 36 citations

Anti-CD19 antibodies inhibit the function of the P-gp pump in multidrug-resistant B lymphoma cells.

1999 • 32 citations

Immunogenicity of immunoliposomes

1991 • 27 citations

Biodistribution of (111)indium-labeled engineered human antibody CTMO1 in ovarian cancer patients: influence of protein dose.

1996 • 25 citations

Sterically stabilized anti-G(M3), anti-Le(x) immunoliposomes: targeting to B16BL6, HRT-18 cancer cells.

1999 • 19 citations

In vivo targeting of surface-modified liposomes to metastatically growing colon carcinoma cells and sinusoidal endothelial cells in the rat liver

1997 • 13 citations

P₀Protein Mediated Targeting of Liposomes to Melanoma Cells with High Level of ICAM-1 Expression

1999 • 7 citations