Translocation of Liposomes into Cancer Cells by Cell-Penetrating Peptides Penetratin and Tat: A Kinetic and Efficacy Study

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

1997 • 2,291 citations

The third helix of the Antennapedia homeodomain translocates through biological membranes.

1994 • 1,964 citations

Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells

2000 • 1,723 citations

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

1991 • 1,591 citations

Tat-mediated delivery of heterologous proteins into cells.

1994 • 1,203 citations

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

1988 • 1,103 citations

Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent

1996 • 1,047 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

2001 • 773 citations

Pharmacokinetics of stealth versus conventional liposomes: effect of dose

1991 • 566 citations

Endocytosis and targeting of exogenous HIV-1 Tat protein.

1991 • 481 citations

Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies.

1995 • 476 citations

Targeting Folate Receptor with Folate Linked to Extremities of Poly(ethylene glycol)-Grafted Liposomes: In Vitro Studies

1999 • 461 citations

Sterically Stabilized Anti-HER2 Immunoliposomes: Design and Targeting to Human Breast Cancer Cells in Vitro

1997 • 438 citations

Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump.

2000 • 401 citations

Endocytosis of liposomes and intracellular fate of encapsulated molecules: Encounter with a low pH compartment after internalization in coated vesicles

1983 • 394 citations

Tumor targeting using anti-her2 immunoliposomes

2001 • 331 citations

Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells.

2001 • 328 citations

Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice.

1992 • 303 citations

Development of anti-p185HER2 immunoliposomes for cancer therapy.

1995 • 258 citations

Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors in vivo.

2001 • 251 citations

Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice.

1993 • 239 citations

A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs

1999 • 232 citations

Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial?

1999 • 222 citations

In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniques with those made by a new post-insertion approach

2001 • 217 citations

Possibility of active targeting to tumor tissues with liposomes

1999 • 211 citations

Endocytosis of liposomes by macrophages: binding, acidification and leakage of liposomes monitored by a new fluorescence assay

1990 • 199 citations

Liposomal Doxorubicin and Conventionally Fractionated Radiotherapy in the Treatment of Locally Advanced Non–Small-Cell Lung Cancer and Head and Neck Cancer

1999 • 189 citations

Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro and in vivo studies

1996 • 179 citations

Efficient cytoplasmic delivery of a fluorescent dye by pH-sensitive immunoliposomes.

1985 • 161 citations

Interactions of immunoliposomes with target cells.

1983 • 146 citations

Imporved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide

1994 • 144 citations

Gemcitabine in Patients With Relapsed or Cisplatin-Refractory Testicular Cancer

1999 • 136 citations

Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: the lack of beneficial effects by coating liposomes with poly(ethylene glycol).

1997 • 124 citations

Anti-HER2 immunoliposomes for targeted therapy of human tumors

1997 • 122 citations

Endocytosis and Transcytosis of an Immunoliposome-Based Brain Drug Delivery System

2000 • 103 citations

A phase II study of pegylated liposomal doxorubicin for treatment of advanced hepatocellular carcinoma

2000 • 95 citations

Antibody-mediated specific binding and cytotoxicity of liposome-entrapped doxorubicin to lung cancer cells in vitro.

1992 • 89 citations

The Effects of pH and Intraliposomal Buffer Strength on the Rate of Liposome Content Release and Intracellular Drug Delivery

1998 • 89 citations

A Novel Chromosome Region Maintenance 1-independent Nuclear Export Signal of the Large Form of Hepatitis Delta Antigen That Is Required for the Viral Assembly

2001 • 85 citations

Poly(ethylene glycol)-Grafted Liposomes with Oligopeptide or Oligosaccharide Ligands Appended to the Termini of the Polymer Chains

1997 • 83 citations

Phase I and pharmacokinetic study of a stable, polyethylene-glycolated liposomal doxorubicin in patients with solid tumors

2001 • 77 citations

Requirements for the internalization of a murine monoclonal antibody directed against the HER-2/neu gene product c-erbB-2.

1991 • 74 citations

Sterically stabilized anti-idiotype immunoliposomes improve the therapeutic efficacy of doxorubicin in a murine B-cell lymphoma model

1999 • 57 citations

Phase II Trial of Liposomal Doxorubicin (Doxil®) in Advanced Soft Tissue Sarcomas

2000 • 47 citations

Kinetic Analysis of Endocytosis and Intracellular Fate of Liposomes in Single Macrophages1

1995 • 37 citations

Programmable fusogenic vesicles for intracellular delivery of antisense oligodeoxynucleotides: enhanced cellular uptake and biological effects

2001 • 31 citations

The effects of polyethyleneglycol (PEG)-derived lipid on the activity of target-sensitive immunoliposome

2000 • 22 citations

Liposomal targeting of leukaemia HL60 cells induced by transferrin‐receptor endocytosis

1996 • 20 citations

Enhanced cytotoxicity of doxorubicin encapsulated in liposomes with reconstituted Sendai F-proteins

2001 • 9 citations

Immunotoxins to the HER-2 oncogene product: Functional and ultrastructural analysis of their cytotoxic activity

1994 • 5 citations