p-Nitrophenylcarbonyl-PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

2000 • 6,190 citations

Determination of free amino groups in proteins by trinitrobenzenesulfonic acid

1966 • 2,029 citations

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

1990 • 1,962 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

1991 • 1,591 citations

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

1988 • 1,103 citations

Liposomes as drug carriers

1977 • 664 citations

Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes

1994 • 532 citations

Vascular and interstitial barriers to delivery of therapeutic agents in tumors

1990 • 485 citations

Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target

1991 • 478 citations

Which polymers can make nanoparticulate drug carriers long-circulating?

1995 • 476 citations

Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity

1994 • 463 citations

Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues

1998 • 451 citations

Radioactive Labeling of Antibody: A Simple and Efficient Method

1983 • 416 citations

Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice.

1989 • 351 citations

New Amphipatic Polymer-Lipid Conjugates Forming Long-Circulating Reticuloendothelial System-Evading Liposomes

1994 • 344 citations

Attachment of antibodies to sterically stabilized liposomes: evaluation, comparison and optimization of coupling procedures

1995 • 312 citations

Molecular mechanism of the lipid vesicle longevity in vivo

1993 • 305 citations

A new strategy for attachment of antibodies to sterically stabilized liposomes resulting in efficient targeting to cancer cells

1995 • 286 citations

Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times

1993 • 284 citations

Delivery of molecular and cellular medicine to solid tumors

1997 • 268 citations

Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol) s conjugated at their distal terminals to monoclonal antibodies

1995 • 262 citations

Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection

1985 • 252 citations

Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo

1994 • 234 citations

Formation and properties of 1000-A-diameter, single-bilayer phospholipid vesicles.

1979 • 228 citations

Targeted accumulation of polyethylene glycol‐coated immunoliposomes in infarcted rabbit myocardium

1992 • 215 citations

Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization / cleavage step

1996 • 213 citations

Possibility of active targeting to tumor tissues with liposomes

1999 • 211 citations

Lectin-bearing polymerized liposomes as potential oral vaccine carriers.

1996 • 193 citations

Why do Polyethylene Glycol-Coated Liposomes Circulate So Long?: Molecular Mechanism of Liposome Steric Protection with Polyethylene Glycol: Role of Polymer Chain Flexibility

1994 • 167 citations

Monoclonal Antibody to Cardiac Myosin: Imaging of Experimental Myocardial Infarction

1984 • 156 citations

Acute myocardial infarct imaging with indium-111-labeled monoclonal antimyosin Fab.

1987 • 145 citations

Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes

1993 • 137 citations

Preservation of antimyosin antibody activity after covalent coupling to liposomes

1979 • 137 citations

Gadolinium-labeled liposomes: targeted MR contrast agents for the liver and spleen.

1987 • 135 citations

Liposomes as targetable drug carriers.

1985 • 126 citations

Vesicle Size Distributions Measured by Flow Field-Flow Fractionation Coupled with Multiangle Light Scattering

1998 • 124 citations

Targetability of novel immunoliposomes prepared by a new antibody conjugation technique

1999 • 115 citations

Optical characterization of liposomes by right angle light scattering and turbidity measurement

2000 • 110 citations

A new hydrophobic anchor for the attachment of proteins to liposomal membranes

1986 • 98 citations

Phosphatidyl polyglycerols prolong liposome circulation in vivo

1994 • 92 citations

Poly(ethylene glycol)-coated anti-cardiac myosin immunoliposomes: factors influencing targeted accumulation in the infarcted myocardium

1996 • 92 citations

Phase II Trial of Liposome-Encapsulated Doxorubicin, Cyclophosphamide, and Fluorouracil as First-Line Therapy in Patients With Metastatic Breast Cancer

1999 • 86 citations

A novel class of antitumor antibodies: nucleosome-restricted antinuclear autoantibodies (ANA) from healthy aged nonautoimmune mice.

1997 • 83 citations

Klinische Wirksamkeit und Ausblicke für die Anwendung von pegyliertem liposomalem Doxorubicin bei der Behandlung von Ovarial- und Mammakarzinomen

1997 • 83 citations

Selective targeting of immunoliposomal doxorubicin against human multiple myeloma in vitro and ex vivo

2000 • 56 citations

Anti-nuclear autoantibodies of the aged reactive against the surface of tumor but not normal cells

1995 • 52 citations

Comparison of dynamic and integrated light-scattering techniques in the study of the interaction of Candida rugosa lipase with DPPC liposomes

1999 • 9 citations