Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection

1989 • 836 citations

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

1990 • 742 citations

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

1988 • 703 citations

Microvascular permeability of normal and neoplastic tissues

1986 • 601 citations

Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

1989 • 571 citations

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

1983 • 560 citations

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

1992 • 501 citations

Animal scale-up

1973 • 389 citations

Transport of fluid and macromolecules in tumors

1991 • 362 citations

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics

1990 • 345 citations

Pharmacokinetics of monoclonal immunoglobulin G1, F(ab')2, and Fab' in mice.

1986 • 308 citations

Extravascular diffusion in normal and neoplastic tissues.

1984 • 294 citations

Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors.

1989 • 257 citations

Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice

1993 • 207 citations

Stability, characterization, and kinetics of 111In-labeled monoclonal antitumor antibodies in normal animals and nude mouse-human tumor models.

1983 • 171 citations

Fluid and protein fluxes across small and large pores in the microvasculature. Application of two‐pore equations

1987 • 165 citations

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.

1992 • 135 citations

Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.

1990 • 108 citations

Biodistribution and radiation dose estimates for yttrium- and iodine-labeled monoclonal antibody IgG and fragments in nude mice bearing human colonic tumor xenografts.

1990 • 106 citations

Extracellular Compartments of Solid Tumors

1975 • 105 citations

Monoclonal antibodies to carcinoembryonic antigen: ionic strength as a factor in the selection of antibodies for immunoscintigraphy.

1983 • 96 citations

Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen.

1992 • 89 citations

Carcinoembryonic antigen production, secretion, and kinetics in BALB/c mice and a nude mouse-human tumor model.

1984 • 79 citations

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.

1991 • 77 citations

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.

1992 • 70 citations

Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding.

1990 • 66 citations

Physiologically based pharmacokinetic models for anticancer drugs

1979 • 64 citations

In vitro measurement and screening of monoclonal antibody affinity using fluoroscence photobleaching

1992 • 23 citations

Vascular permeability and interstitial diffusion in superfused tissues: A two-dimensional model

1988 • 18 citations

Characterization of carcinoembryonic antigen-specific monoclonal antibodies and specific carcinoembryonic antigen assay in sera of patients.

1986 • 11 citations