Selection of tumor-specific internalizing human antibodies from phage libraries

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

By-passing immunization

1991 • 1,603 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Genetic Approach to Facilitate Purification of Recombinant Proteins with a Novel Metal Chelate Adsorbent

1988 • 1,030 citations

Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library

1996 • 1,021 citations

Isolation of high affinity human antibodies directly from large synthetic repertoires.

1994 • 970 citations

"Diabodies": small bivalent and bispecific antibody fragments.

1993 • 861 citations

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides 1 1Edited by I. A. Wilson

2000 • 722 citations

Antibody fragments from a ‘single pot’ phage display library as immunochemical reagents.

1994 • 578 citations

A Large Non-immunized Human Fab Fragment Phage Library That Permits Rapid Isolation and Kinetic Analysis of High Affinity Antibodies

1999 • 527 citations

Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies

1993 • 501 citations

Human anti-self antibodies with high specificity from phage display libraries.

1993 • 480 citations

Sterically Stabilized Anti-HER2 Immunoliposomes: Design and Targeting to Human Breast Cancer Cells in Vitro

1997 • 438 citations

Efficient construction of a large nonimmune phage antibody library: The production of high-affinity human single-chain antibodies to protein antigens

1998 • 437 citations

Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

1996 • 380 citations

Toward cell–targeting gene therapy vectors: Selection of cell–binding peptides from random peptide–presenting phage libraries

1996 • 335 citations

Exploiting recombination in single bacteria to make large phage antibody libraries

2000 • 311 citations

Isolation of High-affinity Monomeric Human Anti-c-erbB-2 Single chain Fv Using Affinity-driven Selection

1996 • 295 citations

Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library.

1995 • 218 citations

Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: selection of specific antibodies from single-chain Fv fusion phage libraries.

1995 • 207 citations

Human Antibody Fragments Specific for Human Blood Group Antigens from a Phage Display Library

1993 • 203 citations

Cell binding and internalization by filamentous phage displaying a cyclic Arg-Gly-Asp-containing peptide.

1994 • 164 citations

Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor cell growth.

1991 • 163 citations

In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library

1995 • 160 citations

Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake.

1995 • 149 citations

Toward Selection of Internalizing Antibodies from Phage Libraries

1999 • 145 citations

A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells.

1996 • 131 citations

Target Cell-specific DNA Transfer Mediated by a Chimeric Multidomain Protein

1996 • 125 citations

Selection of monoclonal antibodies which induce internalization and phosphorylation of P185^HER2 and growth inhibition of cells with HER2/neu gene amplification

1991 • 109 citations

Molecular characterization of murine humoral immune response to botulinum neurotoxin type A binding domain as assessed by using phage antibody libraries

1997 • 105 citations

Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active.

1990 • 105 citations

Isolation of cell surface-specific human monoclonal antibodies using phage display and magnetically-activated cell sorting: applications in immunohematology

1997 • 101 citations

Determination of the binding affinity of an anti-CD34 single-chain antibody using a novel, flow cytometry based assay

1997 • 95 citations

Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragments

1997 • 89 citations

Directed selection of recombinant human monoclonal antibodies to herpes simplex virus glycoproteins from phage display libraries.

1995 • 83 citations

Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase

1993 • 76 citations

An optimized method for cell-based phage display panning

1997 • 73 citations

Monoclonal antibodies against defined epitopes of the human transferrin receptor cytoplasmic tail

1992 • 69 citations

Regulated expression of foreign genes fused tolac:control by glucose levels in growth medium

1990 • 62 citations

In vitro antigen challenge of human antibody libraries for vaccine evaluation: the human immunodeficiency virus type 1 envelope

1996 • 50 citations

Isolation of cDNA clones for the human transferrin receptor.

1983 • 46 citations

Pathfinder selection: in situ isolation of novel antibodies

1998 • 45 citations

A model system for detection and isolation of a tumor cell surface antigen using antibody phage display

1997 • 41 citations

Ligand-like effects induced by anti-c-erbB-2 antibodies do not correlate with and are not required for growth inhibition of human carcinoma cells.

1994 • 30 citations

Methodology for selection of human antibodies to membrane proteins from a phage-display library

1997 • 25 citations

Targeted therapy of Schwannoma cells in immunocompetent rats with an erbB2-specific antibody-toxin

1997 • 23 citations

Differing Sensitivity of Non-Hematopoietic Human Tumors to Synergistic Anti-Transferrin Receptor Monoclonal Antibodies and Deferoxamine in vitro

1995 • 16 citations

The blockage of the human transferrin receptor by a monoclonal antibody, EA.3, induces growth inhibition in leukemia cell lines.

1994 • 4 citations

UCSF targets cancer IND

1998 • 3 citations