Conformational Regulation of Integrin Structure and Function

Comparative Protein Modelling by Satisfaction of Spatial Restraints

1993 • 12,640 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Integrin Signaling

1999 • 3,705 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

De Novo Protein Design: Fully Automated Sequence Selection

1997 • 1,129 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

2001 • 1,035 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Exposure of platelet fibrinogen receptors by ADP and epinephrine.

1979 • 868 citations

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1990 • 709 citations

Breaking the Integrin Hinge

1996 • 567 citations

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1993 • 546 citations

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

1993 • 523 citations

Chemokines Trigger Immediate β2 Integrin Affinity and Mobility Changes

2000 • 517 citations

[25] Ribbons

1997 • 511 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

Differential Dynamics of α5 Integrin, Paxillin, and α-Actinin during Formation and Disassembly of Adhesions in Migrating Cells

2001 • 439 citations

Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

1997 • 414 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

2001 • 338 citations

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

2002 • 313 citations

Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy.

1992 • 309 citations

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

1995 • 308 citations

Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium

1995 • 281 citations

Crystal Structure of the I Domain from Integrin α2β1

1997 • 275 citations

Are changes in integrin affinity and conformation overemphasized?

1998 • 257 citations

Crystal Structure of the von Willebrand Factor A1 Domain and Implications for the Binding of Platelet Glycoprotein Ib

1998 • 255 citations

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. Cohen

1999 • 255 citations

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.

2001 • 255 citations

Regulation of leukocyte integrin function: Affinity vs. avidity

1996 • 244 citations

Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin αIIbβ3

1998 • 239 citations

Functional Consequences of Integrin Gene Mutations in Mice

2001 • 238 citations

The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand

1998 • 225 citations

Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activityin vivo

2001 • 214 citations

Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis

2000 • 210 citations

Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead

2000 • 205 citations

Integrin-mediated cell adhesion: the extracellular face.

1994 • 204 citations

Domains in plexins: links to integrins and transcription factors

1999 • 204 citations

A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1

1998 • 201 citations

Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the β-subunits of the integrin family

1991 • 197 citations

A mechanism for divalent cation regulation of beta 3-integrins.

1994 • 196 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

Long range propagation of conformational changes in integrin alpha IIb beta 3.

1993 • 188 citations

Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains

2001 • 184 citations

Specific Association Of CD63 with the VLA-3 and VLA-6 Integrins

1995 • 181 citations

Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity

1997 • 176 citations

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

2000 • 165 citations

The Actin Cytoskeleton Regulates LFA-1 Ligand Binding through Avidity Rather than Affinity Changes

1999 • 165 citations

A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

1995 • 164 citations

Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State

2001 • 163 citations

Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin β2 Subunit Reveals Regions that Become Exposed Upon Receptor Activation

2001 • 161 citations

I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1.

1994 • 151 citations

Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences.

1994 • 149 citations

Conformational changes in tertiary structure near the ligand binding site of an integrin I domain

1999 • 143 citations

An Isoleucine-based Allosteric Switch Controls Affinity and Shape Shifting in Integrin CD11b A-domain

2000 • 142 citations

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1996 • 134 citations

Cutting Edge: A Small Molecule Antagonist of LFA-1-Mediated Cell Adhesion

1999 • 133 citations

Integrin Structure

2000 • 132 citations

Computational design of an integrin I domain stabilized in the open high affinity conformation.

2000 • 131 citations

An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond

2001 • 129 citations

Binding Site Elucidation of Hydantoin-Based Antagonists of LFA-1 Using Multidisciplinary Technologies: Evidence for the Allosteric Inhibition of a Protein−Protein Interaction

2001 • 128 citations

Two Functional States of the CD11b A-Domain: Correlations with Key Features of Two Mn2+-complexed Crystal Structures

1998 • 127 citations

Integrin Activation by Dithiothreitol or Mn2+ Induces a Ligand-occupied Conformation and Exposure of a Novel NH2-terminal Regulatory Site on the β1Integrin Chain

1998 • 119 citations

Evolution of domain families

2000 • 101 citations

Multiple Discontinuous Ligand-mimetic Antibody Binding Sites Define a Ligand Binding Pocket in Integrin αIIbβ3

2000 • 97 citations

Structural and Functional Studies with Antibodies to the Integrin β2 Subunit

2000 • 96 citations

Critical Threonine and Aspartic Acid Residues within the I Domains of β2 Integrins for Interactions with Intercellular Adhesion Molecule 1 (ICAM-1) and C3bi

1995 • 95 citations

Trench-shaped Binding Sites Promote Multiple Classes of Interactions between Collagen and the Adherence Receptors, α1β1 Integrin and Staphylococcus aureus Cna MSCRAMM

1999 • 94 citations

Getting integrins into shape: recent insights into how integrin activity is regulated by conformational changes

1996 • 94 citations

Folding and Function of I Domain-deleted Mac-1 and Lymphocyte Function-associated Antigen-1

2000 • 86 citations

Experimental support for a β-propeller domain in integrin α-subunits and a calcium binding site on its lower surface

1998 • 80 citations

Amino Acid Residues in the αIIb Subunit That Are Critical for Ligand Binding to Integrin αIIbβ3 Are Clustered in the β-Propeller Model

2001 • 78 citations

NMR solution structure of the inserted domain of human leukocyte function associated antigen-1

2000 • 78 citations

Molecular Regulation of the Interaction Between Leukocyte Function-Associated Antigen-1 and Soluble ICAM-1 by Divalent Metal Cations

1998 • 77 citations

Micromolar Ca2+ Concentrations Are Essential for Mg2+-dependent Binding of Collagen by the Integrin α2β1 in Human Platelets

2000 • 77 citations

Folding of the β-propeller domain of the integrin α_Lsubunit is independent of the I domain and dependent on the β₂ subunit

1997 • 73 citations

Cation binding to the integrin CD11b I domain and activation model assessment

1998 • 73 citations

The Lymphocyte Function–associated Antigen 1 I Domain Is a Transient Binding Module for Intercellular Adhesion Molecule (ICAM)-1 and ICAM-3 in Hydrodynamic Flow

1997 • 71 citations

von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule.

2000 • 68 citations

Crystal structure of the α1β1 integrin I‐domain: insights into integrin I‐domain function

1999 • 64 citations

Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha 6beta 4

1999 • 64 citations

Long range propagation of conformational changes in integrin αIIbβ3

1994 • 63 citations

Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin β subunits

2001 • 63 citations

Amino Acid Residues in the PSI Domain and Cysteine-rich Repeats of the Integrin β2 Subunit That Restrain Activation of the Integrin αxβ2

2001 • 62 citations

Folding of the conserved domain but not of flanking regions in the integrin β₂subunit requires association with the α subunit

1997 • 61 citations

The Structure of the β-Propeller Domain and C-terminal Region of the Integrin αM Subunit

1998 • 58 citations

A small-molecule antagonist of LFA-1 blocks a conformational change important for LFA-1 function

2001 • 58 citations

KIM127, an Antibody that Promotes Adhesion, Maps to a Region of CD18 that Includes Cysteine-Rich Repeats

1995 • 56 citations

Structure/function analysis of the integrin beta 1 subunit by epitope mapping

1993 • 54 citations

Activation-induced Conformational Changes in the I Domain Region of Lymphocyte Function-associated Antigen 1

2002 • 51 citations

Mapping the Intercellular Adhesion Molecule-1 and -2 Binding Site on the Inserted Domain of Leukocyte Function-associated Antigen-1

1998 • 50 citations

Effects of I Domain Deletion on the Function of the β2 Integrin Lymphocyte Function-associated Antigen-1

2000 • 47 citations

A Discrete Site Modulates Activation of I Domains

1996 • 46 citations

Molecular cloning of the mouse integrin beta 7 subunit.

1992 • 39 citations

The Top of the Inserted-like Domain of the Integrin Lymphocyte Function-associated Antigen-1 β Subunit Contacts the α Subunit β-Propeller Domain near β-Sheet 3

2000 • 37 citations

Structural basis of integrin-mediated signal transduction

1997 • 36 citations

Green fluorescent protein (GFP) tagged to the cytoplasmic tail of αIIb or β3 allows the expression of a fully functional integrin αIIbβ3: effect of β3GFP on αIIbβ3 ligand binding

2001 • 29 citations

Cloning and expression of the chicken CD18 cDNA

1994 • 20 citations

The ’ ligand-induced conformational change’ of α5βl integrin: Relocation of α5 subunit to uncover the β1 stalk region

1998 • 19 citations

Defining the repeating elements in the cysteine‐rich region (CRR) of the CD18 integrin β2 subunit

2001 • 18 citations