NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

Discovering High-Affinity Ligands for Proteins: SAR by NMR

1996 • 1,986 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Empirical correlation between protein backbone conformation and C.alpha. and C.beta. 13C nuclear magnetic resonance chemical shifts

1991 • 1,072 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1990 • 709 citations

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

1993 • 523 citations

Divalent cation regulation of the function of the leukocyte integrin LFA-1.

1992 • 492 citations

Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

1997 • 414 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Heteronuclear three-dimensional nmr spectroscopy. A strategy for the simplification of homonuclear two-dimensional NMR spectra

1988 • 382 citations

LFA-1–mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca2+-dependent Protease, Calpain

1998 • 324 citations

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

1995 • 308 citations

Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules

1997 • 282 citations

Crystal Structure of the I Domain from Integrin α2β1

1997 • 275 citations

[11] Multidimensional heteronuclear nuclear magnetic resonance of proteins

1994 • 269 citations

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. Cohen

1999 • 255 citations

Crystal Structure of the von Willebrand Factor A1 Domain and Implications for the Binding of Platelet Glycoprotein Ib

1998 • 255 citations

Regulation of leukocyte integrin function: Affinity vs. avidity

1996 • 244 citations

The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand

1998 • 225 citations

Identification by NMR of the Binding Surface for the Histidine-Containing Phosphocarrier Protein HPr on the N-Terminal Domain of Enzyme I of the Escherichia coli Phosphotransferase System

1997 • 217 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction.

1995 • 167 citations

A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

1995 • 164 citations

I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1.

1994 • 151 citations

Conformational changes in tertiary structure near the ligand binding site of an integrin I domain

1999 • 143 citations

A novel LFA-1 activation epitope maps to the I domain.

1993 • 136 citations

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1996 • 134 citations

KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA‐1‐ and CR3‐dependent adhesion

1993 • 127 citations

Two Functional States of the CD11b A-Domain: Correlations with Key Features of Two Mn2+-complexed Crystal Structures

1998 • 127 citations

Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, HPr and IIAglc

1993 • 126 citations

The von Willebrand Factor A3 Domain Does Not Contain a Metal Ion-dependent Adhesion Site Motif

1997 • 115 citations

Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1.

1993 • 101 citations

The I Domain of Integrin Leukocyte Function-associated Antigen-1 Is Involved in a Conformational Change Leading to High Affinity Binding to Ligand Intercellular Adhesion Molecule 1 (ICAM-1)

1998 • 101 citations

Determinants of Ligand Binding Specificity of the α1β1 and α2β1Integrins

1999 • 96 citations

Critical Threonine and Aspartic Acid Residues within the I Domains of β2 Integrins for Interactions with Intercellular Adhesion Molecule 1 (ICAM-1) and C3bi

1995 • 95 citations

Trench-shaped Binding Sites Promote Multiple Classes of Interactions between Collagen and the Adherence Receptors, α1β1 Integrin and Staphylococcus aureus Cna MSCRAMM

1999 • 94 citations

Identification by NMR Spectroscopy of Residues at Contact Surfaces in Large, Slowly Exchanging Macromolecular Complexes

1999 • 94 citations

Molecular Regulation of the Interaction Between Leukocyte Function-Associated Antigen-1 and Soluble ICAM-1 by Divalent Metal Cations

1998 • 77 citations

Cation binding to the integrin CD11b I domain and activation model assessment

1998 • 73 citations

Identification of Amino Acids in the CD11a I-domain Important for Binding of the Leukocyte Function-associated Antigen-1 (LFA-1) to Intercellular Adhesion Molecule-1 (ICAM-1)

1995 • 73 citations

KIM127, an Antibody that Promotes Adhesion, Maps to a Region of CD18 that Includes Cysteine-Rich Repeats

1995 • 56 citations

Monoclonal Antibodies That Block the Activity of Leukocyte Function-associated Antigen 1 Recognize Three Discrete Epitopes in the Inserted Domain of CD11a

1995 • 51 citations

Mapping the Intercellular Adhesion Molecule-1 and -2 Binding Site on the Inserted Domain of Leukocyte Function-associated Antigen-1

1998 • 50 citations

Identification of the binding site in intercellular adhesion molecule 1 for its receptor, leukocyte function-associated antigen 1.

1997 • 48 citations

A Discrete Site Modulates Activation of I Domains

1996 • 46 citations

IMPLICATIONS OF ATOMIC-RESOLUTION STRUCTURES FOR CELL ADHESION

1997 • 38 citations

Differential regulation of chemoattractant-stimulated beta 2, beta 3, and beta 7 integrin activity.

1998 • 37 citations

Differential Regulation of Chemoattractant-Stimulated β2, β3, and β7 Integrin Activity

1998 • 33 citations