Are changes in integrin affinity and conformation overemphasized?

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

Breaking the Integrin Hinge

1996 • 567 citations

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

1993 • 523 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Divalent cation regulation of the function of the leukocyte integrin LFA-1.

1992 • 492 citations

Integrin Activation by R-ras

1996 • 414 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1996 • 343 citations

Post-translational Modifications of Recombinant P-selectin Glycoprotein Ligand-1 Required for Binding to P- and E-selectin

1996 • 340 citations

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

1990 • 328 citations

Activated Conformations of Very Late Activation Integrins Detected by a Group of Antibodies (HUTS) Specific for a Novel Regulatory Region(355-425) of the Common β1 Chain

1996 • 298 citations

Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium

1995 • 281 citations

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.

1988 • 280 citations

The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor.

1988 • 279 citations

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

1991 • 270 citations

Ins and outs of LFA-1

1995 • 260 citations

T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1.

1996 • 249 citations

Regulation of leukocyte integrin function: Affinity vs. avidity

1996 • 244 citations

Integrin activation: the link between ligand binding and signal transduction

1996 • 227 citations

Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand binding

1994 • 220 citations

Integrin-mediated cell adhesion: the extracellular face.

1994 • 204 citations

The Conserved Membrane-proximal Region of an Integrin Cytoplasmic Domain Specifies Ligand Binding Affinity

1995 • 202 citations

Long range propagation of conformational changes in integrin alpha IIb beta 3.

1993 • 188 citations

Regulation of Integrin Affinity States through an NP XY Motif in the β Subunit Cytoplasmic Domain

1995 • 181 citations

Specific Association Of CD63 with the VLA-3 and VLA-6 Integrins

1995 • 181 citations

Mutational Evidence for Control of Cell Adhesion Through Integrin Diffusion/Clustering, Independent of Ligand Binding

1997 • 179 citations

Topography of Ligand-induced Binding Sites, Including a Novel Cation-sensitive Epitope (AP5) at the Amino Terminus, of the Human Integrin β3 Subunit

1995 • 169 citations

Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction.

1995 • 167 citations

A monoclonal antibody reacting with distinct adhesion molecules defines a transition in the functional state of the receptor CD11b/CD18 (Mac-1).

1988 • 166 citations

Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1.

1997 • 166 citations

A conformation-dependent epitope of human platelet glycoprotein IIIa

1990 • 162 citations

Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia.

1986 • 161 citations

Identification of a novel anti‐integrin monoclonal antibody that recognises a ligand‐induced binding site epitope on the β1 subunit

1995 • 151 citations

Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences.

1994 • 149 citations

α4β1Integrin-dependent Cell Adhesion Is Regulated by a Low Affinity Receptor Pool That Is Conformationally Responsive to Ligand

1995 • 147 citations

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1996 • 134 citations

Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified platelet glycoprotein IIb-IIIa.

1987 • 133 citations

Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin.

1993 • 100 citations

Vascular Cell Adhesion Molecule (VCAM)-Ig Fusion Protein Defines Distinct Affinity States of the Very Late Antigen-4 (VLA-4) Receptor

1995 • 98 citations

Control of β1 Integrin Function

1996 • 79 citations

Dynamic regulation of integrins

1995 • 67 citations

A highly conserved sequence of the Arg-Gly-Asp-binding domain of the integrin beta 3 subunit is sensitive to stimulation

1991 • 60 citations

Regulation of Conformation and Ligand Binding Function of Integrin α5β1 by the β1 Cytoplasmic Domain

1996 • 49 citations

Defining Extracellular Integrin α-Chain Sites That Affect Cell Adhesion and Adhesion Strengthening without Altering Soluble Ligand Binding

1997 • 37 citations

Monoclonal antibody to an activation neoepitope of alpha M beta 2 inhibits multiple alpha M beta 2 functions.

1994 • 32 citations

Integrin α chain cytoplasmic tails regulate “antibody‐redirected” cell adhesion, independently of ligand binding

1997 • 18 citations