Two conformations of the integrin A-domain (I-domain): a pathway for activation?

Advanced inorganic chemistry

1999 • 14,227 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Advanced inorganic chemistry

1973 • 7,079 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 962 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 785 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1989 • 615 citations

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1993 • 546 citations

Crystal structure of active elongation factor Tu reveals major domain rearrangements

1993 • 533 citations

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

1993 • 523 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1990 • 514 citations

Divalent cation regulation of the function of the leukocyte integrin LFA-1.

1992 • 492 citations

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

1990 • 489 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Integrin-ligarid interactions: a year in review

1994 • 282 citations

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

1991 • 270 citations

Long range propagation of conformational changes in integrin alpha IIb beta 3.

1993 • 188 citations

Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).

1994 • 184 citations

Integrin α2 I-domain is a binding site for collagens

1995 • 172 citations

A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

1995 • 164 citations

Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion.

1991 • 154 citations

I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1.

1994 • 151 citations

Identification of putative ligand binding sites within I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29)

1994 • 148 citations

Data Collection and Processing

1980 • 143 citations

Identification of putative ligand binding sites within I domain of integrin α2β1 (VLA-2,CD49b/CD29).

1996 • 136 citations

A novel LFA-1 activation epitope maps to the I domain.

1993 • 136 citations

Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain.

1994 • 135 citations

The role of the I domain in ligand binding of the human integrin alpha 1 beta 1.

1994 • 125 citations

β2 (CD18) Mutations Abolish Ligand Recognition by I Domain Integrins LFA-1 ( αLβ2, CD11a/CD18) and MAC-1 ( αMβ2, CD11b/CD18)

1995 • 83 citations

Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18.

1991 • 73 citations

Dynamic regulation of integrins

1995 • 67 citations

Long range propagation of conformational changes in integrin αIIbβ3

1994 • 63 citations

Characterization of a gain of function mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa).

1992 • 43 citations

Proteolytic degradation of the RGD-binding and non-RGD-binding conformers of human platelet integrin glycoprotein IIb/IIIa: clues for identification of regions involved in the receptor's activation

1994 • 26 citations

Adhesion Molecules and the Lung

1996 • 17 citations

Deleted Work

1955 • 0 citations