The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Determination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation

1991 • 1,123 citations

Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure.

1990 • 1,013 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1993 • 546 citations

Divalent cation regulation of the function of the leukocyte integrin LFA-1.

1992 • 492 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

Model bias in macromolecular crystal structures

1992 • 397 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

1995 • 308 citations

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

1989 • 285 citations

Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand binding

1994 • 220 citations

The superfamily of proteins with von Willebrand factor type A-like domains: one theme common to components of extracellular matrix, hemostasis, cellular adhesion, and defense mechanisms

1991 • 206 citations

Valence Screening of Water in Protein Crystals Reveals Potential Na+Binding Sites

1996 • 205 citations

Protein Flexibility and Adaptability Seen in 25 Crystal Forms of T4 Lysozyme

1995 • 193 citations

Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner

1994 • 164 citations

A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

1995 • 164 citations

Histogram matching as a new density modification technique for phase refinement and extension of protein molecules

1990 • 163 citations

I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1.

1994 • 151 citations

The role of the I domain in ligand binding of the human integrin alpha 1 beta 1.

1994 • 125 citations

The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.

1994 • 118 citations

Involvement of the "I" domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3.

1994 • 102 citations

Crystallization of a fragment of human fibronectin: Introduction of methionine by site‐directed mutagenesis to allow phasing via selenomethionine

1994 • 90 citations

Integrin LFA-1 alpha subunit contains an ICAM-1 binding site in domains V and VI.

1994 • 85 citations

β2 (CD18) Mutations Abolish Ligand Recognition by I Domain Integrins LFA-1 ( αLβ2, CD11a/CD18) and MAC-1 ( αMβ2, CD11b/CD18)

1995 • 83 citations

Identification of Amino Acids in the CD11a I-domain Important for Binding of the Leukocyte Function-associated Antigen-1 (LFA-1) to Intercellular Adhesion Molecule-1 (ICAM-1)

1995 • 73 citations

Variability of conformations at crystal contacts in BPTI represent true low‐energy structures: Correspondence among lattice packing and molecular dynamics structures

1992 • 69 citations

Structure of the Radical Form of Clostridial Flavodoxin: A New Molecular Model

1972 • 61 citations

Labeling of integrin alpha v beta 3 with 58Co(III). Evidence of metal ion coordination sphere involvement in ligand binding

1991 • 58 citations

Energetics of Leukocyte Integrin Activation

1995 • 54 citations

Critical amino acids in the lymphocyte function-associated antigen-1 I domain mediate intercellular adhesion molecule 3 binding and immune function.

1996 • 44 citations

Lymphocyte adhesion molecules

1995 • 41 citations

T lymphocyte adhesion molecules.

1989 • 31 citations