Two Functional States of the CD11b A-Domain: Correlations with Key Features of Two Mn2+-complexed Crystal Structures

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex.

1985 • 593 citations

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1993 • 546 citations

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

1993 • 523 citations

Biospecific interaction analysis using biosensor technology

1993 • 522 citations

Localization of an Arg-Gly-Asp Recognition Site Within an Integrin Adhesion Receptor

1988 • 402 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

1995 • 308 citations

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol).

1983 • 303 citations

The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor.

1988 • 279 citations

Crystal Structure of the I Domain from Integrin α2β1

1997 • 275 citations

The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit.

1988 • 238 citations

Specificity of Membrane Complement Receptor Type Three (CR3) for ß-Glucans

1987 • 233 citations

The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand

1998 • 225 citations

Incorporation of fast Fourier transforms to speed restrained least-squares refinement of protein structures

1987 • 221 citations

7E3 Monoclonal Antibody Directed Against the Platelet Glycoprotein IIb/IIIa Cross-reacts With the Leukocyte Integrin Mac-1 and Blocks Adhesion to Fibrinogen and ICAM-1

1997 • 220 citations

Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand binding

1994 • 220 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

Long range propagation of conformational changes in integrin alpha IIb beta 3.

1993 • 188 citations

Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).

1994 • 184 citations

Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies.

1986 • 174 citations

Integrin α2 I-domain is a binding site for collagens

1995 • 172 citations

Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner

1994 • 164 citations

A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

1995 • 164 citations

C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp.

1987 • 163 citations

Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor.

1988 • 160 citations

Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion.

1991 • 154 citations

Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation.

1994 • 154 citations

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.

1992 • 151 citations

I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1.

1994 • 151 citations

Mutation of a ligand binding domain of beta 3 integrin. Integral role of oxygenated residues in alpha IIb beta 3 (GPIIb-IIIa) receptor function.

1994 • 147 citations

Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.

1993 • 144 citations

A novel LFA-1 activation epitope maps to the I domain.

1993 • 136 citations

Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain.

1994 • 135 citations

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1996 • 134 citations

A Mutational Analysis of the Binding of Two Different Proteins to the Same Antibody

1996 • 131 citations

Analysis of active antibody concentration. Separation of affinity and concentration parameters

1993 • 131 citations

Identification of putative ligand-binding sites of the integrin α4β1 (VLA-4, CD49d/CD29)

1995 • 128 citations

The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.

1994 • 118 citations

Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain.

1995 • 114 citations

The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF.

1994 • 113 citations

Involvement of the "I" domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3.

1994 • 102 citations

Critical Threonine and Aspartic Acid Residues within the I Domains of β2 Integrins for Interactions with Intercellular Adhesion Molecule 1 (ICAM-1) and C3bi

1995 • 95 citations

Overlapping, but Not Identical, Sites Are Involved in the Recognition of C3bi, Neutrophil Inhibitory Factor, and Adhesive Ligands by the αMβ2 Integrin

1996 • 91 citations

Cation binding to the integrin CD11b I domain and activation model assessment

1998 • 73 citations

Interactions of human complement component C3 with factor B and with complement receptors type 1 (CR1, CD35) and type 3 (CR3, CD11b/CD18) involve an acidic sequence at the N-terminus of C3 alpha'-chain.

1994 • 65 citations

Long range propagation of conformational changes in integrin αIIbβ3

1994 • 63 citations

Distinct Ligand Binding Sites in the I Domain of Integrin αMβ2 That Differentially Affect a Divalent Cation-dependent Conformation

1995 • 59 citations

Solvent-accessible Residues on the Metal Ion-dependent Adhesion Site Face of Integrin CR3 Mediate Its Binding to the Neutrophil Inhibitory Factor

1996 • 57 citations

Energetics of Leukocyte Integrin Activation

1995 • 54 citations

A Discrete Site Modulates Activation of I Domains

1996 • 46 citations

C3bi受容器(3型補体受容器)によるArg‐Gly‐Asp鎖を含むC3領域の認識

1987 • 46 citations

Biosynthesis and function of membrane bound and secreted forms of recombinant CD11b/CD18 (Mac‐1)

1993 • 14 citations

Deleted Work

1955 • 0 citations