Conformational changes in tertiary structure near the ligand binding site of an integrin I domain

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.

1982 • 615 citations

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1993 • 546 citations

Interactions of protein antigens with antibodies.

1996 • 543 citations

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

1993 • 523 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

1997 • 414 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

1995 • 308 citations

The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.

1988 • 281 citations

Crystal Structure of the I Domain from Integrin α2β1

1997 • 275 citations

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

1991 • 270 citations

Are changes in integrin affinity and conformation overemphasized?

1998 • 257 citations

Crystal Structure of the von Willebrand Factor A1 Domain and Implications for the Binding of Platelet Glycoprotein Ib

1998 • 255 citations

Integrin activation: the link between ligand binding and signal transduction

1996 • 227 citations

Integrin-mediated cell adhesion: the extracellular face.

1994 • 204 citations

Long range propagation of conformational changes in integrin alpha IIb beta 3.

1993 • 188 citations

Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor.

1988 • 160 citations

Dependence of Globin Gene Expression in Mouse Erythroleukemia Cells on the NF-E2 Heterodimer

1995 • 158 citations

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.

1992 • 151 citations

The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1.

1997 • 150 citations

Cell adhesion in vascular biology. New insights into integrin-ligand interaction.

1997 • 139 citations

Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain.

1994 • 135 citations

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1996 • 134 citations

The structure of cell-adhesion molecules

1998 • 108 citations

A structure prediction for the ligand‐binding region of the integrin β subunit: evidence for the presence of a von Willebrand factor A domain

1997 • 104 citations

Use of simian virus 40 replication to amplify Epstein-Barr virus shuttle vectors in human cells

1988 • 88 citations

The structure of cell-adhesion molecules

1998 • 83 citations

Experimental support for a β-propeller domain in integrin α-subunits and a calcium binding site on its lower surface

1998 • 80 citations

Cation binding to the integrin CD11b I domain and activation model assessment

1998 • 73 citations

Multiple loop structures critical for ligand binding of the integrin α4 subunit in the upper face of the β-propeller mode 1

1997 • 60 citations

The Structure of the β-Propeller Domain and C-terminal Region of the Integrin αM Subunit

1998 • 58 citations

A Discrete Site Modulates Activation of I Domains

1996 • 46 citations

Proteolytic degradation of the RGD-binding and non-RGD-binding conformers of human platelet integrin glycoprotein IIb/IIIa: clues for identification of regions involved in the receptor's activation

1994 • 26 citations

Induction of Aquaporin-1 mRNA following Cardiopulmonary Bypass and Reperfusion

1997 • 10 citations