Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. Cohen

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Analytical molecular surface calculation

1983 • 2,454 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis

1998 • 514 citations

Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

1997 • 414 citations

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1995 • 400 citations

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

1995 • 308 citations

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

1989 • 285 citations

Pharmacology of competitive inhibitors of HMg-CoA reductase

1995 • 276 citations

Crystal Structure of the I Domain from Integrin α2β1

1997 • 275 citations

[11] Multidimensional heteronuclear nuclear magnetic resonance of proteins

1994 • 269 citations

The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand

1998 • 225 citations

A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1

1998 • 201 citations

A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

1995 • 164 citations

I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1.

1994 • 151 citations

Conformational changes in tertiary structure near the ligand binding site of an integrin I domain

1999 • 143 citations

Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain.

1994 • 135 citations

Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding

1997 • 135 citations

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1996 • 134 citations

Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface

1997 • 132 citations

The role of the I domain in ligand binding of the human integrin alpha 1 beta 1.

1994 • 125 citations

The von Willebrand Factor A3 Domain Does Not Contain a Metal Ion-dependent Adhesion Site Motif

1997 • 115 citations

Regulation of locomotion and cell-cell contact area by the LFA-1 and ICAM-1 adhesion receptors.

1992 • 112 citations

The I Domain of Integrin Leukocyte Function-associated Antigen-1 Is Involved in a Conformational Change Leading to High Affinity Binding to Ligand Intercellular Adhesion Molecule 1 (ICAM-1)

1998 • 101 citations

The effects of intermediate exchange processes on the estimation of equilibrium constants by NMR

1979 • 99 citations

Critical Threonine and Aspartic Acid Residues within the I Domains of β2 Integrins for Interactions with Intercellular Adhesion Molecule 1 (ICAM-1) and C3bi

1995 • 95 citations

Cation binding to the integrin CD11b I domain and activation model assessment

1998 • 73 citations

Identification of Amino Acids in the CD11a I-domain Important for Binding of the Leukocyte Function-associated Antigen-1 (LFA-1) to Intercellular Adhesion Molecule-1 (ICAM-1)

1995 • 73 citations

An E-Selectin Binding Assay Based on a Polyacrylamide-Type Glycoconjugate

1996 • 62 citations

Distinct Ligand Binding Sites in the I Domain of Integrin αMβ2 That Differentially Affect a Divalent Cation-dependent Conformation

1995 • 59 citations

LONG-TERM SURVIVAL OF SOLID ORGAN ALLOGRAFTS BY BRIEF ANTI-LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 MONOCLONAL ANTIBODY MONOTHERAPY

1996 • 55 citations

Monoclonal Antibodies That Block the Activity of Leukocyte Function-associated Antigen 1 Recognize Three Discrete Epitopes in the Inserted Domain of CD11a

1995 • 51 citations

Mapping the Intercellular Adhesion Molecule-1 and -2 Binding Site on the Inserted Domain of Leukocyte Function-associated Antigen-1

1998 • 50 citations

Characterization of molecular interactions between intercellular adhesion molecule-1 and leukocyte function- associated antigen-1.

1996 • 50 citations

Critical amino acids in the lymphocyte function-associated antigen-1 I domain mediate intercellular adhesion molecule 3 binding and immune function.

1996 • 44 citations

Antibodies That Selectively Inhibit Leukocyte Function-associated Antigen 1 Binding to Intercellular Adhesion Molecule-3 Recognize a Unique Epitope within the CD11a I Domain

1996 • 37 citations

Structural basis of integrin-mediated signal transduction

1997 • 36 citations