Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

de la Chapelle, A.

1997 • 3,184 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

1990 • 1,793 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

1996 • 1,498 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1995 • 1,171 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

The molecular biology of apoptosis.

1996 • 963 citations

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

1996 • 917 citations

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 • 820 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

1995 • 706 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

A License to Kill

1996 • 649 citations

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

1994 • 622 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

The role of proteases during apoptosis

1996 • 558 citations

Inhibition of apoptosis during development of colorectal cancer.

1995 • 548 citations

Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53‐independent pathway: Implications for the possible role of dietary fibre in the prevention of large‐bowel cancer

1993 • 539 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

The Pancreas : biology, pathobiology, and disease

1993 • 501 citations

Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest.

1994 • 497 citations

Increased Plasma Tumor Necrosis Factor in Severe Alcoholic Hepatitis

1990 • 470 citations

Induction and activation of tissue transglutaminase during programmed cell death

1987 • 467 citations

Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats

1990 • 457 citations

In situ detection of fragmented DNA (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note*1

1995 • 453 citations

Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors

1996 • 438 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Extreme sensitivity of some intestinal crypt cells to X and γ irradiation

1977 • 417 citations

Apoptosis in colorectal tumour cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate

1995 • 411 citations

The molecular biology of apoptoseis.

1996 • 390 citations

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1995 • 377 citations

Potentiation by specific short-chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines.

1994 • 365 citations

Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C

1994 • 363 citations

The cell-death machine

1996 • 351 citations

Regulation of intestinal epithelial cell growth by transforming growth factor type beta.

1989 • 341 citations

The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice

1992 • 334 citations

Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release.

1995 • 332 citations

Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine

1992 • 330 citations

Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species

1996 • 324 citations

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.

1996 • 318 citations

Abrogation of p53-Induced Apoptosis by the Hepatitis B Virus X Gene

2003 • 318 citations

Regulation of Liver Growth: Protooncogenes and Transforming Growth Factors

1990 • 315 citations

Expression of APO‐1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium

1994 • 310 citations

Differential expression of bcl-2 in intestinal epithelia correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia

1995 • 308 citations

Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis

1995 • 302 citations

Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver.

1994 • 274 citations

Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes.

1994 • 270 citations

Apoptosis and hepatobiliary disease

1995 • 268 citations

TGF-β signalling through the Smad pathway

1997 • 265 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: A possible role in ulcerative colitis

1997 • 249 citations

The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis

1996 • 236 citations

Hepatocyte apoptosis: Is transforming growth factor-B1 the kiss of death? Oberhammer FA, Pavelka M, Sharma S, Tietenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc Natl Acad Sci USA 1992;89:5408–5412

1993 • 233 citations

Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells.

1997 • 230 citations

TGF-β1 influences the relative development of the exocrine and endocrine pancreas in vitro

1994 • 215 citations

Activin induces cell death in hepatocytes in vivo and in vitro

1993 • 206 citations

The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model.

1995 • 205 citations

Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins

1997 • 203 citations

Characterization of Radiation-induced Apoptosis in the Small Intestine and Its Biological Implications

1994 • 202 citations

Fas-Mediated Apoptosis in Primary Cultured Mouse Hepatocytes

1994 • 202 citations

Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL.

1995 • 200 citations

Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo

1995 • 196 citations

Epithelial cell growth and differentiation. II. Intestinal apoptosis

1997 • 190 citations

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin.

1994 • 186 citations

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

1997 • 185 citations

Role of Fas Ligand in Apoptosis Induced by Hepatitis C Virus Infection

1994 • 180 citations

Occurrence of cell death (apoptosis) during the involution of liver hyperplasia.

1985 • 174 citations

G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2.

1996 • 173 citations

bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas

1995 • 170 citations

Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas

1997 • 165 citations

Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes

1997 • 165 citations

Bafilomycin inhibits proton flow through the H+ channel of vacuolar proton pumps

1994 • 160 citations

The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins.

1996 • 151 citations

Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat

1996 • 148 citations

Apoptosis is induced by transforming growth factor-beta 1 within 5 hours in regressing liver without significant fragmentation of the DNA.

1993 • 142 citations

Protective effect of hepatocyte growth factor on interferon-gamma—induced cytotoxicity in mouse hepatocytes

1995 • 135 citations

p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma.

1995 • 134 citations

Progress in Liver Diseases.

1970 • 134 citations

The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells

1996 • 131 citations

APOPTOSIS AS A MECHANISM OF CELL DEATH IN LIVER ALLOGRAFT REJECTION1,2

1995 • 124 citations

Epidemiology of adenocarcinomas of the small intestine: is bile a small bowel carcinogen?

1991 • 124 citations

Assembly of Bcl-2 into microsomal and outer mitochondrial membranes

1994 • 123 citations

Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C

1997 • 122 citations

APOPTOSIS AS A MECHANISM OF CELL DEATH IN LIVER ALLOGRAFT REJECTION1,2

1995 • 118 citations

Characterization of cell volume loss in CEM-C7A cells during dexamethasone-induced apoptosis

1996 • 114 citations

TGF-β expression in the human colon: differential immunostaining along crypt epithelium

1993 • 113 citations

Apoptosis is induced by transforming growth factor-β1 within 5 hours in regressing liver without significant fragmentation of the DNA

1993 • 111 citations

Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer

1997 • 107 citations

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

1996 • 101 citations

The Fate of Effete Epithelial Cells at the Villus Tips of the Human Small Intestine.

1995 • 98 citations

Malignant Tumors of the Small Intestine

1986 • 97 citations

Active cell death (apoptosis) in liver biology and disease.

1995 • 94 citations

Concanavalin A induces perforin-mediated but not Fas-mediated hepatic injury

1996 • 91 citations

Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice.

1997 • 91 citations

Induction of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells.

1995 • 90 citations

Changes in the Mouse Exocrine Pancreas after Pancreatic Duct Ligation: A Qualitative and Quantitative Histological Study.

1995 • 80 citations

Ultrastructural lesions of bile ducts in primary biliary cirrhosis

1981 • 79 citations

Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy.

1995 • 79 citations

Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma

1994 • 79 citations

Growth, regression and cell death in rat liver as related to tissue levels of the hepatomitogen cyproterone acetate

1986 • 77 citations

Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus

1985 • 77 citations

Concanavalin A induces perforin-mediated but not Fas-mediated hepatic injury

1996 • 75 citations

Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor‐beta in fetal hepatocytes in primary culture

1996 • 70 citations

Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration.

1996 • 69 citations

Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor ?

1996 • 68 citations

Ultrastructure of the Rat Pancreas after Experimental Duct Ligation. II. Duct and Stromal Cell Proliferation, Differentiation, and Deletion

1992 • 68 citations

Early detachment of colon carcinoma cells during CD95(APO-1/Fas)-mediated apoptosis. I. De-adhesion from hyaluronate by shedding of CD44.

1996 • 66 citations

Loss of apc protein expressed by human colonic epithelial cells and the appearance of a specific low‐molecular‐weight form is associated with apoptosis IN vitro

1994 • 62 citations

Hepatic fibrogenesis: the puzzle of interacting cells, fibrogenic cytokines, regulatory loops, and extracellular matrix molecules.

1992 • 61 citations

Apoptosis in Human Hepatoma Cell Line Induced by 4,5-Didehydro geranylgeranoic Acid (Acyclic Retinoid) via Down-Regulation of Transforming Growth Factor-α

1996 • 61 citations

Two-stage control of cell proliferation induced in rat liver by alpha-hexachlorocyclohexane.

1977 • 61 citations

Paneth cells express high levels of CD95 ligand transcripts: a unique property among gastrointestinal epithelia.

1996 • 60 citations

Hepatic transdifferentiation in the pancreas

1995 • 59 citations

Development of resistance to the growth inhibitory effects of transforming growth factor beta 1 during the spontaneous transformation of rat liver epithelial cells.

1991 • 58 citations

Biology of Disease Regulation of Liver Growth: Protooncogenes and Transforming Growth Factors

1990 • 53 citations

Increased nitric oxide synthase activity as a cause of mitochondrial dysfunction in rat hepatocytes: roles for tumor necrosis factor ?

1996 • 52 citations

Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice

1997 • 48 citations

Ethionine-Induced Atrophy of Rat Pancreas Involves Apoptosis of Acinar Cells

1993 • 44 citations

Automatic Counting of Microscopic Particles

1952 • 43 citations

Induction of Apoptosis Reduces the Severity of Caerulein-Induced Pancreatitis in Mice

1996 • 43 citations

Elevated plasma levels of hyaluronic acid indicate endothelial cell dysfunction in the initial stages of alcoholic liver disease in the rat

1996 • 38 citations

Cell acidification in apoptosis

1996 • 38 citations

Familial Pancreatic Cancer and the Genetics of Pancreatic Cancer

1995 • 37 citations

DNA alterations in cells from hereditary non-polyposis colorectal cancer patients.

1994 • 35 citations

Transforming growth factor beta 1: in situ expression in the liver of patients with chronic hepatitis C treated with alpha interferon.

1993 • 26 citations

Apoptosis of acinar cells in the pancreas of rats fed on a copper-depleted diet

1994 • 25 citations

Hepatocyte growth factor (HGF) and its receptor (Met) in liver regeneration, neoplasia, and disease

1995 • 17 citations

Malignant Tumors of the Small Bowel

1984 • 14 citations

Inhibition of growth and induction of TGF-β1 in human hepatocellular carcinoma with androgen receptor by cyproterone acetate in male nude mice

1996 • 10 citations

Cis-acting elements required for expression of the nonspecific cross- reacting antigen gene in colorectal carcinoma

1997 • 6 citations

Deleted Work

1955 • 0 citations