Development of resistance to the growth inhibitory effects of transforming growth factor beta 1 during the spontaneous transformation of rat liver epithelial cells.

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY

1969 • 940 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Three different fibronectin mRNAs arise by alternative splicing within the coding region

1983 • 713 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Construction of DNA sequences complementary to rat .alpha.1 and .alpha.2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D

1984 • 568 citations

Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation.

1988 • 483 citations

Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

1990 • 413 citations

A simple, rapid method for the purification of poly A+ RNA.

1988 • 382 citations

Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis

1984 • 345 citations

Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets

1983 • 258 citations

The Role of Dna Methylation in Cancer

1990 • 244 citations

Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture.

1986 • 224 citations

An Evaluation of Cellular Lineages in the Pathogenesis of Experimental Hepatocellular Carcinoma

1982 • 176 citations

Labile Methyl Groups and the Promotion of Cancer

1986 • 169 citations

Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet

1984 • 165 citations

Hepatocarcinomas, cholangiocarcinomas, and hepatoblastomas produced by chemically transformed cultured rat liver epithelial cells. A light- and electron-microscopic analysis.

1987 • 143 citations

Test for Malignant Transformation of Rat Liver Cells in Culture: Cytology, Growth in Soft Agar, and Production of Plasminogen Activator

1977 • 123 citations

Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus

1985 • 118 citations

Growth in culture and tumorigenicity after transfection with the ras oncogene of liver epithelial cells from carcinogen-treated rats.

1987 • 116 citations

Synthesis in vitro of Keratin Polypeptides Directed by mRNA Isolated from Newborn and Adult Mouse Epidermis

1980 • 106 citations

Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events.

1991 • 102 citations

Studies of the retinoblastoma gene in human sarcomas.

1989 • 100 citations

Sequential alterations in growth control and cell dynamics of rat hepatocytes in early precancerous steps in hepatocarcinogenesis.

1986 • 88 citations

Transforming growth factors produced by normal and neoplastically transformed rat liver epithelial cells in culture.

1988 • 88 citations

Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine

1984 • 86 citations

Neoplastic Transformation In Vitro of a Clone of Adult Liver Epithelial Cells into Differentiated Hepatoma-Like Cells Under Conditions of Nutritional Stress

1972 • 86 citations

Genetic and Epigenetic Losses of Heterozygosity in Cancer Predisposition and Progression

1990 • 79 citations

Measurement of cell proliferation in microculture using hoechst 33342 for the rapid semiautomated microfluorimetric determination of chromatin DNA

1985 • 73 citations

Cellular distribution of c-myc transcripts during chemical hepatocarcinogenesis in rats.

1988 • 63 citations

Altered responsiveness of rat liver epithelial cells to transforming growth factor beta 1 following their transformation with v-raf.

1990 • 37 citations

A diploid rat liver cell culture

1975 • 35 citations

Altered expression of retrovirus-like sequences and cellular oncogenes in mice fed methyl-deficient diets.

1989 • 33 citations

Hepatomas in Choline Deficiency<xref ref-type="fn" rid="fn1">1</xref>, <xref ref-type="fn" rid="fn2">2</xref>

1955 • 32 citations

Growth modulatory effects of a liver-derived growth inhibitor, transforming growth factor β1, and recombinant tumor necrosis factor α, in normal and neoplastic cells

1989 • 28 citations

Expression and phenotypic alterations caused by an inducible transforming ras oncogene introduced into rat liver epithelial cells.

1988 • 26 citations

Altered tRNA methylation in rats and mice fed lipotrope-deficient diets

1986 • 25 citations

Expression of growth-related genes during tumor progression in v-raf-transformed rat liver epithelial cells.

1990 • 22 citations

Increased sensitivity of nontumorigenic fibroblasts expressing ras or myc oncogenes to malignant transformation induced by 5-aza-2'-deoxycytidine.

1991 • 21 citations

Isolation and characterization of a rat liver epithelial cell line resistant to the antiproliferative effects of transforming growth factor beta (type 1).

1990 • 11 citations