Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES

1964 • 3,400 citations

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

The multistep nature of cancer

1993 • 1,872 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer

1991 • 375 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

Pancreatic adenocarcinomas frequently show p53 gene mutations.

1993 • 332 citations

Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies.

1982 • 239 citations

Carcinoma of the Pancreas

1964 • 223 citations

Frequent loss of heterozygosity at the DCC locus in gastric cancer.

1992 • 204 citations

p53 and K-RAS alterations in pancreatic epithelial cell lesions.

1993 • 186 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer

1991 • 173 citations

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes.

1992 • 171 citations

Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma.

1992 • 126 citations

Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein.

1990 • 114 citations

Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts.

1992 • 88 citations

p53 Gene mutations in gastric and esophageal cancers

1992 • 77 citations

CisModification of the Steroid 21-Hydroxylase Gene Prevents Its Expression in the Y1 Mouse Adrenocortical Tumor Cell Line

1990 • 67 citations

Characterization of Clones of a Human Pancreatic Adenocarcinoma Cell Line Representing Different Stages of Differentiation

1989 • 62 citations

Genetic alterations in human gastric cancer.

1991 • 60 citations

Growth factors and oncogenes in pancreatic cancer

1990 • 40 citations

Structural analysis of a new highly metastatic cell line PaTu 8902 from a primary human pancreatic adenocarcinoma

1993 • 40 citations

Loss of heterozygosity on 3p in a renal cell carcinoma in von Hippel-Lindau syndrome

1989 • 29 citations