The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

A system for shotgun DNA sequencing

1981 • 2,710 citations

Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undegraded polysomes and messenger ribonucleic acid

1974 • 987 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing

1984 • 563 citations

Crystallization, Characterization and Metabolic Regulation of Two Types of Pyruvate Kinase Isolated from Rat Tissues*

1967 • 456 citations

Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å

1979 • 444 citations

A single mouse α-amylase gene specifies two different tissue-specific mRNAs

1981 • 402 citations

Alternative transcription and two modes of splicing result in two myosin light chains from one gene

1984 • 400 citations

The rat serum albumin gene: analysis of cloned sequences.

1979 • 400 citations

Multimolecular Forms of Pyruvate Kinase from Rat and Other Mammalian Tissues*

1972 • 359 citations

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene

1985 • 314 citations

Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing.

1984 • 265 citations

The structure of cat muscle pyruvate kinase.

1986 • 245 citations

Multimolecular Forms of Pyruvate Kinase

1972 • 156 citations

Intron/exon structure of the chicken pyruvate kinase gene

1985 • 144 citations

[25] Pyruvate kinase isozymes from rat

1982 • 141 citations

[59] Determination of RNA sequences by primer directed synthesis and sequencing of their cDNA transcripts

1980 • 137 citations

Identification of multiple species of calmodulin messenger RNA using a full length complementary DNA.

1983 • 131 citations

Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region.

1985 • 122 citations

Electrophoretic and Kinetic Studies of Mutant Erythrocyte Pyruvate Kinases

1974 • 94 citations

Primary structure of chicken muscle pyruvate kinase mRNA.

1983 • 93 citations

Complete nucleotide and deduced amino acid sequences of rat L‐type pyruvate kinase

1986 • 62 citations

Complete amino acid sequence of rat L-type pyruvate kinase deduced from the cDNA sequence

1986 • 57 citations

Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9

1981 • 47 citations

The M1 and M2 subunits of rat pyruvate kinase are encoded by different messenger RNAs.

1982 • 43 citations

Peptide structures of pyruvate kinase isozymes

1982 • 34 citations

Molecular cloning of DNA complementary to rat L-type pyruvate kinase mRNA. Nutritional and hormonal regulation of L-type pyruvate kinase mRNA concentration.

1983 • 34 citations

ALANINE INHIBITION OF PYRUVATE KINASE IN GLIOMAS AND MENINGIOMAS A DIAGNOSTIC TOOL IN SURGERY FOR GLIOMAS?

1977 • 21 citations

Molecular cloning of cDNA sequences for rat M2-type pyruvate kinase and regulation of its mRNA.

1984 • 20 citations

Muscle and liver pyruvate kinases are closely related: amino acid sequence comparisons

1984 • 18 citations

THE CAUDAL HEART IN THE EEL AND CONGER.

1832 • 1 citations