Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

The nucleotide sequence of the rat cytoplasmic β–actin gene

1983 • 1,059 citations

Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

1980 • 947 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Computer methods to locate signals in nucleic acid sequences

1984 • 673 citations

The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro

1983 • 593 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

The structure and evolution of the two nonallelic rat preproinsulin genes

1979 • 500 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1984 • 474 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts

1983 • 396 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein

1983 • 333 citations

Messenger RNA splicing in vitro: An excised intervening sequence and a potential intermediate

1984 • 262 citations

Alternative RNA splicing of the murine αA-crystallin gene: Protein-coding information within an intron

1983 • 251 citations

Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: Implications for U1 RNA and metazoan mRNA splicing

1983 • 239 citations

U2 RNA shares a structural domain with U1, U4, and U5 RNAs.

1982 • 236 citations

Nucleotide sequence of the rat skeletal muscle actin gene

1982 • 207 citations

The primary structure of the human ε-globin gene

1980 • 195 citations

The complete nucleotide sequence of the Neurospora crassa am (NADP-specific glutamate dehydrogenase) gene

1983 • 175 citations

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

1981 • 161 citations

A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events

1980 • 158 citations

Base-pairing interactions between small nuclear RNAs and nuclear RNA precursors as revealed by psoralen cross-linking in vivo

1981 • 148 citations

Complete nucleotide sequence of the human δ-globin gene

1980 • 146 citations

Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes.

1980 • 138 citations

The genes coding for histone H3 and H4 inNeurospora crassaare unique and contain intervening sequences

1983 • 137 citations

Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.

1980 • 136 citations

Polyadenylylated nuclear RNA contains branches

1983 • 120 citations

Complete nucleotide sequence of mouse imunoglobulin μ gene and comparison with other immunoglobulin heavy chain genes

1980 • 108 citations

Small Nuclear RNAs and RNA Processing

1983 • 90 citations

Post-transcriptional processing of simian virus 40 late transcripts in injected frog oocytes

1983 • 88 citations

Isolation and structure of a rat cytochrome c gene.

1981 • 87 citations

The nucleotide sequence of a rat myosin light chain 2 gene

1984 • 83 citations

Small Nuclear RNA U2 Is Base-Paired to Heterogeneous Nuclear RNA

1982 • 67 citations

The complete nucleotide sequence of mouse immunoglobulin γ2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer

1981 • 66 citations

Nucleotide sequence analysis of viable deletion mutants lacking segments of the simian virus 40 genome coding for small t antigen

1979 • 64 citations

Yeast is unable to excise foreign intervening sequences from hybrid gene transcripts.

1983 • 64 citations

Strict co-linearity of genetic and protein folding domains in an intragenically duplicated rat lens γ-crystallin gene

1983 • 56 citations

DNA sequence of two linked actin genes of sea urchin.

1983 • 40 citations

Aberrant splicing of Drosophila alcohol dehydrogenase transcripts in Saccharomyces cerevisiae.

1983 • 38 citations

DNA Sequence of Two Linked Actin Genes of Sea Urchin

1983 • 16 citations

RNA processing: Sequences that signal where to splice

1983 • 15 citations