Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

The structure and evolution of the human β-globin gene family

1980 • 1,398 citations

pEMBL: a new family of single stranded plasmids

1983 • 1,231 citations

Are snRNPs involved in splicing?

1980 • 1,206 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes

1983 • 627 citations

Recognition of cap structure in splicing in vitro of mRNA precursors

1984 • 575 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1984 • 474 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts

1983 • 396 citations

Lariat structures are in vivo intermediates in yeast pre-mRNA splicing

1984 • 379 citations

Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products

1983 • 373 citations

A single-base change at a splice site in a β0-thalassemic gene causes abnormal RNA splicing

1982 • 372 citations

Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site

1982 • 353 citations

Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.

1984 • 342 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

A minimal intron length but no specific internal sequence is required for splicing the large rabbit β-globin intron

1984 • 328 citations

Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: The role of intragenic sequences

1984 • 312 citations

Messenger RNA splicing in vitro: An excised intervening sequence and a potential intermediate

1984 • 262 citations

SYNTHESIS AND USE OF SYNTHETIC OLIGONUCLEOTIDES

1984 • 260 citations

cis and trans activation of globin gene transcription in transient assays.

1983 • 257 citations

Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: Implications for U1 RNA and metazoan mRNA splicing

1983 • 239 citations

Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene

1983 • 235 citations

Characterization of the branch site in lariat RNAs produced by splicing of mRNA precursors

1985 • 232 citations

In vivo splicing products of the rabbit β-globin pre-mRNA

1984 • 209 citations

BKV splice sequences based on analysis of preferred donor and acceptor sites

1979 • 198 citations

In vivo characterization of yeast mRNA processing intermediates

1984 • 152 citations

Simple, efficientin vitrosynthesis of capped RNA useful for direct expression of cloned eukaryoti genes

1982 • 152 citations

Simian virus 40 enhancer increases number of RNA polymerase II molecules on linked DNA

1985 • 138 citations

Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing

1979 • 123 citations

Abnormal RNA splicing causes one form of α thalassemia

1982 • 120 citations

The RNA lariat: A new ring to the splicing of mRNA precursors

1984 • 113 citations

An adenovirus mutant defective in splicing RNA from early region 1A

1981 • 78 citations

Nucleotide sequence deletions within the coding region for small-t antigen of simian virus 40

1979 • 72 citations

Deletions at intervening sequence splice sites in the alcohol dehydrogenase gene ofDrosophila

1982 • 70 citations

Nucleotide sequence analysis of viable deletion mutants lacking segments of the simian virus 40 genome coding for small t antigen

1979 • 64 citations

EXPRESSION OF β-GLOBIN GENES MODIFIED BY RESTRUCTURING AND SITE-DIRECTED MUTAGENESIS

1981 • 11 citations