Cytochrome P450 and Vascular Homeostasis

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

On the local reactions of the arterial wall to changes of internal pressure

1902 • 1,485 citations

Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors

1996 • 1,226 citations

Anti-inflammatory Properties of Cytochrome P450 Epoxygenase-Derived Eicosanoids

1999 • 1,158 citations

Cytochrome P450 2C is an EDHF synthase in coronary arteries

1999 • 909 citations

Human Cytochrome P450 Enzymes

1995 • 731 citations

Cytochrome P450 and the Individuality of Species

1999 • 573 citations

Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase

2000 • 546 citations

Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and γ-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus

2001 • 485 citations

Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450 Arachidonic Acid Epoxygenase Highly Expressed in Heart

1996 • 469 citations

Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids

2000 • 458 citations

Endothelium-Derived Hyperpolarizing Factor Synthase (Cytochrome P450 2C9) Is a Functionally Significant Source of Reactive Oxygen Species in Coronary Arteries

2001 • 434 citations

Nitric Oxide Attenuates the Release of Endothelium-Derived Hyperpolarizing Factor

1996 • 433 citations

Characterization of endothelium‐derived hyperpolarizing factor as a cytochrome P450‐derived arachidonic acid metabolite in mammals.

1994 • 430 citations

Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation

2000 • 336 citations

Renal cytochrome P450-related arachidonate metabolite inhibits (Na+ + K+)ATPase

1985 • 314 citations

Human sympathetic and vagal baroreflex responses to sequential nitroprusside and phenylephrine

1999 • 297 citations

Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.

1981 • 295 citations

Signaling by dual specificity kinases

1998 • 291 citations

High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors.

1992 • 280 citations

Overexpression of Cytochrome P450 CYP2J2 Protects against Hypoxia-Reoxygenation Injury in Cultured Bovine Aortic Endothelial Cells

2001 • 266 citations

Epoxyeicosatrienoic Acids Activate K ⁺ Channels in Coronary Smooth Muscle Through a Guanine Nucleotide Binding Protein

1997 • 262 citations

Flow-Induced Dilation of Human Coronary Arterioles

2001 • 257 citations

Identification and Functional Characterization of a New CYP2C9 Variant (CYP2C9*5) Expressed among African Americans

2001 • 253 citations

Production of Reactive Oxygen Species by Microsomes Enriched in Specific Human Cytochrome P450 Enzymes

1998 • 244 citations

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

2001 • 239 citations

Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species

1994 • 235 citations

Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors.

1998 • 234 citations

Molecular Cloning, Expression, and Functional Significance of a Cytochrome P450 Highly Expressed in Rat Heart Myocytes

1997 • 228 citations

Coronary arteriolar myogenic response is independent of endothelium.

1990 • 226 citations

Cytochrome P450: progress and predictions

1992 • 211 citations

Pulsatile Stretch Stimulates Superoxide Production and Activates Nuclear Factor-κB in Human Coronary Smooth Muscle

1997 • 206 citations

Human Coronary Arteriolar Dilation to Bradykinin Depends on Membrane Hyperpolarization

1999 • 202 citations

Inhibition of 20-HETE Production Contributes to the Vascular Responses to Nitric Oxide

1997 • 198 citations

Activation of K+ channel in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acid

1993 • 196 citations

Molecular Characterization of an Arachidonic Acid Epoxygenase in Rat Brain Astrocytes

1996 • 193 citations

20-HETE and the kidney: resolution of old problems and new beginnings

1999 • 191 citations

Display of the characteristics of endothelium‐derived hyperpolarizing factor by a cytochrome P450‐derived arachidonic acid metabolite in the coronary microcirculation

1994 • 189 citations

CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells

1999 • 188 citations

Pulsatile Stretch Stimulates Superoxide Production in Human Aortic Endothelial Cells

1997 • 186 citations

Eicosanoid regulation of the renal vasculature

2000 • 183 citations

In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors

1996 • 178 citations

Pressure and flow‐dependent vascular tone

1991 • 176 citations

A transferable, beta‐naphthoflavone‐inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells.

1996 • 174 citations

Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole.

1997 • 172 citations

Isolation of preferentially expressed genes in the kidneys of hypertensive rats.

1991 • 170 citations

Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats.

1994 • 169 citations

Human Coronary Arteriolar Dilation to Arachidonic Acid Depends on Cytochrome P-450 Monooxygenase and Ca ²⁺ -Activated K ⁺ Channels

1998 • 165 citations

Cytochrome P450 Metabolites of Arachidonic Acid as Intracellular Signaling Molecules in Vascular Tissue

1997 • 165 citations

Nitric Oxide-20–Hydroxyeicosatetraenoic Acid Interaction in the Regulation of K ⁺ Channel Activity and Vascular Tone in Renal Arterioles

1998 • 164 citations

Cytochrome P-450 may link intracellular Ca2+ stores with plasma membrane Ca2+ influx

1991 • 164 citations

Inhibition of Cardiac L-Type Calcium Channels by Epoxyeicosatrienoic Acids

1999 • 164 citations

20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase.

1997 • 156 citations

Role of CYP2C9 polymorphism in losartan oxidation.

2001 • 151 citations

Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors

1999 • 150 citations

EET homologs potently dilate coronary microvessels and activate BK_Cachannels

2001 • 145 citations

Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties.

1991 • 145 citations

Angiotensin II releases 20-HETE from rat renal microvessels

2000 • 143 citations

Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450

2000 • 136 citations

Role of P-450 Arachidonic Acid Epoxygenase in the Response of Cerebral Blood Flow to Glutamate in Rats

1997 • 135 citations

Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4???-hydroxylation activities in livers of Japanese and Caucasian populations

1997 • 134 citations

Epoxyeicosatrienoic Acids and Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation and Induce Mitogenesis in Renal Epithelial Cells

1998 • 134 citations

Potentiation of Endothelium-Dependent Relaxation by Epoxyeicosatrienoic Acids

1997 • 133 citations

Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release

2000 • 129 citations

Nifedipine Increases Cytochrome P4502C Expression and Endothelium-Derived Hyperpolarizing Factor–Mediated Responses in Coronary Arteries

2000 • 128 citations

Vasodilation to Bradykinin Is Mediated by an Ouabain-Sensitive Pathway as a Compensatory Mechanism for Impaired Nitric Oxide Availability in Essential Hypertensive Patients

1999 • 127 citations

The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading

1999 • 124 citations

Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats.

1993 • 122 citations

Renal And Cardiovascular Actions Of 20‐Hydroxyeicosatetraenoic Acid And Epoxyeicosatrienoic Acids

2000 • 122 citations

Interaction of Sulfaphenazole Derivatives with Human Liver Cytochromes P450 2C: Molecular Origin of the Specific Inhibitory Effects of Sulfaphenazole on CYP 2C9 and Consequences for the Substrate Binding Site Topology of CYP 2C9

1996 • 121 citations

Cytochrome P450‐dependent effects of bradykinin in the rat heart

1995 • 121 citations

Epoxygenase Metabolites Contribute to Nitric Oxide-Independent Afferent Arteriolar Vasodilation in Response to Bradykinin

2001 • 119 citations

Inhibition of renal arachidonic acid ω-hydroxylase activity with ABT reduces blood pressure in the SHR

1998 • 118 citations

11,12-Epoxyeicosatrienoic Acid Stimulates Endogenous Mono-ADP-Ribosylation in Bovine Coronary Arterial Smooth Muscle

1999 • 117 citations

Pulsatile Stretch in Coronary Arteries Elicits Release of Endothelium-Derived Hyperpolarizing Factor

1998 • 116 citations

Transfection of an Active Cytochrome P450 Arachidonic Acid Epoxygenase Indicates That 14,15-Epoxyeicosatrienoic Acid Functions as an Intracellular Second Messenger in Response to Epidermal Growth Factor

1999 • 113 citations

Renal cytochrome P-450-arachidonic acid metabolism: localization and hormonal regulation in SHR

1992 • 112 citations

P450 SUBFAMILY CYP2J AND THEIR ROLE IN THE BIOACTIVATION OF ARACHIDONIC ACID IN EXTRAHEPATIC TISSUES*

1999 • 110 citations

The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells

2001 • 109 citations

CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR

2001 • 108 citations

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

1996 • 108 citations

In vivo location and mechanism of EDHF-mediated vasodilation in canine coronary microcirculation

1999 • 107 citations

Flow modulates myogenic responses in isolated microperfused rabbit afferent arterioles via endothelium-derived nitric oxide.

1995 • 107 citations

Arachidonic acid epoxygenase: Structural characterization and quantification of epoxyeicosatrienoates in plasma

1992 • 107 citations

Localization of cytochromeP-450 4A isoforms along the rat nephron

1998 • 106 citations

Age-related changes in renal cytochrome P-450 arachidonic acid metabolism in spontaneously hypertensive rats

1992 • 102 citations

Antisense oligonucleotides against cytochrome P450 2C8 attenuate EDHF‐mediated Ca ²⁺ changes and dilation in isolated resistance arteries

2000 • 101 citations

Functional Implications of a Newly Characterized Pathway of 11,12-Epoxyeicosatrienoic Acid Metabolism in Arterial Smooth Muscle

1996 • 100 citations

Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries

2000 • 99 citations

Cytochrome P450 metabolites of arachidonic acid in the control of renal function

2001 • 98 citations

Afferent Arteriolar Vasodilation to the Sulfonimide Analog of 11,12-Epoxyeicosatrienoic Acid Involves Protein Kinase A

1999 • 98 citations

The lung HETEs (and EETs) up

2001 • 97 citations

14,15-Epoxyeicosatrienoic acid metabolism in endothelial cells.

1993 • 97 citations

The Stoichiometry of the Cytochrome P-450-catalyzed Metabolism of Methoxyflurane and Benzphetamine in the Presence and Absence of Cytochrome b5

1995 • 90 citations

Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney.

2000 • 90 citations

Identification of Arachidonate P-450 Metabolites in Human Platelet Phospholipids

1995 • 87 citations

Is EDHF an epoxyeicosatrienoic acid?

2000 • 86 citations

Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta

1991 • 85 citations

Arachidonic Acid Diols Produced by Cytochrome P-450 Monooxygenases Are Incorporated into Phospholipids of Vascular Endothelial Cells

1996 • 84 citations

High frequency of mutations related to impaired CYP2C9 metabolism in a Caucasian population.

2001 • 84 citations

Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness

1999 • 84 citations

Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes

2000 • 81 citations

Removal of Glutathione Produces Apoptosis and Necrosis in HepG2 Cells Overexpressing CYP2E1

2001 • 77 citations

Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids

1999 • 76 citations

Binding of Cytochrome P450 Monooxygenase and Lipoxygenase Pathway Products by Heart Fatty Acid-Binding Protein

2001 • 76 citations

Cytochrome P-450 Metabolites Mediate Norepinephrine-Induced Mitogenic Signaling

1998 • 73 citations

Abnormal pressure-natriuresis in hypertension: role of cytochrome P450 metabolites of arachidonic acid

2001 • 71 citations

Arachidonic acid epoxygenase

1990 • 70 citations

Enhanced acetylcholine and P2Y-receptor stimulated vascular EDHF-dilatation in congestive heart failure

1999 • 68 citations

Microsomal monooxygenase in apoptosis: another target for cytochrome c signaling?

2001 • 68 citations

Myogenic Responses Are Independent of the Endothelium in Rat Pressurized Posterior Cerebral Arteries

1989 • 63 citations

Functional response of the rat kidney to inhibition of nitric oxide synthesis: role of cytochrome P450‐derived arachidonate metabolites

1998 • 62 citations

Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCA-salt hypertension

1999 • 62 citations

Gene Structure and Upstream Regulatory Regions of Human CYP2C9 and CYP2C18

1993 • 62 citations

Developmentally Regulated Expression of theCYP4AGenes in the Spontaneously Hypertensive Rat Kidney

1997 • 59 citations

Attenuation of coronary autoregulation in the isolated rabbit heart by endothelium derived nitric oxide

1994 • 58 citations

Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs

2001 • 57 citations

Contribution of cytochrome P-450 ω-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension

2000 • 56 citations

Role of Cytochrome P-450 in Elevating Renal Vascular Tone in Spontaneously Hypertensive Rats

1993 • 55 citations

Effect of CYP2C Polymorphisms on the Pharmacokinetics of Phenytoin in Japanese Patients with Epilepsy.

1996 • 52 citations

Pharmacological evaluation of an epoxide as the putative hyperpolarizing factor mediating the nitric oxide-independent vasodilator effect of bradykinin in the rat heart.

1998 • 51 citations

Overexpression of C-terminal Src Kinase Blocks 14,15-Epoxyeicosatrienoic Acid-induced Tyrosine Phosphorylation and Mitogenesis

2000 • 50 citations

Cytochrome P450 metabolites of arachidonic acid may be important mediators in angiotensin II-induced vasoconstriction in the rat mesentery in vivo

2000 • 48 citations

Myogenic activation of canine small renal arteries after nonchemical removal of the endothelium

1994 • 47 citations

Cells in culture from rabbit medullary thick ascending limb of Henle's loop

1989 • 46 citations

Cytochrome P450 metabolites of arachidonic acid: rapid incorporation and hydration of 14,15-epoxyeicosatrienoic acid in arterial smooth muscle cells

1997 • 46 citations

Effect of Protein Kinase C Modulators on 14,15‐Epoxyeicosatrienoic Acid Incorporation into Astroglial Phospholipids

1995 • 45 citations

Metabolism of 5,6-epoxyeicosatrienoic acid by the human platelet. Formation of novel thromboxane analogs.

1991 • 44 citations

A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs)

1987 • 43 citations

Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes

2000 • 41 citations

Human Umbilical Vein Endothelial Cells Express P450 2C8 mRNA: Cloning of Endothelial P450 Epoxygenase

1996 • 39 citations

Joint Time and Time-Frequency Optimal Detection of K-Complexes in Sleep EEG

1998 • 39 citations

Epoxyeicosatrienoic Acid–Mediated Renal Vasodilation to Arachidonic Acid Is Enhanced in SHR

2001 • 32 citations

Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide

2001 • 30 citations

Small GTP binding protein Ras contributes to norepinephrine-induced mitogenesis of vascular smooth muscle cells

2001 • 29 citations

Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices

1990 • 26 citations

Arachidonic acid metabolic pathways regulating activity of renal Na⁺-K⁺-ATPase are age dependent

2000 • 23 citations

BK_Ca channels compensate for loss of NOS-dependent coronary artery relaxation in cardiomyopathy

2000 • 18 citations

Renal functional effects of endothelins: dependency on cytochrome P450-derived arachidonate metabolites.

1998 • 15 citations

Effect of aging on renal cytochrome P450-dependent arachidonic acid metabolism in Dahl rats.

1993 • 11 citations

CYTOCHROME P‐450‐DEPENDENT ARACHIDONATE METABOLITES AND RENAL FUNCTIONS IN THE LYON HYPERTENSIVE RAT

1998 • 5 citations