In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The determination of enzyme inhibitor constants

1953 • 4,050 citations

A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors (Short Communication)

1974 • 908 citations

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1992 • 605 citations

Pharmacokinetic Drug Interactions of Macrolides

1992 • 355 citations

Plasma protein binding displacement interactions—why are they still regarded as clinically important?

1994 • 297 citations

Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug.

1990 • 240 citations

Speculations on the Substrate Structure-Activity Relationship (SSAR) of cytochrome P450 enzymes

1992 • 203 citations

Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin

1991 • 199 citations

Biotransformation of lovastatin

1991 • 195 citations

Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme a reductase

1994 • 191 citations

Clinical Pharmacokinetics and Practical Applications of Simvastatin

1993 • 182 citations

Drug metabolism in human liver in vitro: Establishment of a human liver bank

1980 • 176 citations

Disposition of pravastatin sodium, a tissue‐selective HMG‐CoA reductase inhibitor, in healthy subjects.

1990 • 174 citations

Pharmacokinetics of Fluvastatin After Single and Multiple Doses in Normal Volunteers

1992 • 170 citations

Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver

1993 • 154 citations

Comparative Pharmacokinetics and Pharmacodynamics of Pravastatin and Lovastatin

1990 • 149 citations

Concentrations of Pravastatin and Lovastatin in Cerebrospinal Fluid in Healthy Subjects

1991 • 126 citations

The physiological disposition of lovastatin.

1989 • 123 citations

Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

1989 • 117 citations

In vitro forecasting of drugs which may interfere with the biotransformation of midazolam

1991 • 107 citations

In vivo inhibition profile of cytochrome P450TB (CYP2C9) by (±)-fluvastatin*

1995 • 105 citations

Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics

1993 • 90 citations

[55] Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds

1991 • 84 citations

Pharmacokinetics of Fluvastatin and Specific Drug Interactions

1993 • 82 citations

Pharmacokinetics and pharmacodynamics of pravastatin alone and with cholestyramine in hypercholesterolemia

1990 • 82 citations

Simvastatin: The clinical profile

1989 • 80 citations

Physiological Disposition of Hmg-Coa-Reductase Inhibitors

1990 • 68 citations

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation

1987 • 63 citations

Comparison of Fluvastatin and Lovastatin Blood-Brain Barrier Transfer Using In Vitro and In Vivo Methods

1993 • 59 citations

Lovastatin. Warfarin interaction

1990 • 54 citations

Pharmacokinetic interaction between propranolol and the HMG‐CoA reductase inhibitors pravastatin and lovastatin.

1991 • 43 citations

Tissue-selective action of pravastatin due to hepatocellular uptake via a sodium-independent bile acid transporter

1992 • 38 citations

Binding of Fluvastatin to Blood Cells and Plasma Proteins

1993 • 38 citations

Hepatic vectorial transport of xenobiotics

1994 • 36 citations

Suspected Interaction: Warfarin and Erythromycin

1985 • 23 citations

Steady state serum concentrations of pravastatin and digoxin when given in combination.

1993 • 20 citations