Identification and Functional Characterization of a New CYP2C9 Variant (CYP2C9*5) Expressed among African Americans

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

1992 • 1,168 citations

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

1998 • 820 citations

The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

1996 • 584 citations

Biochemistry and molecular biology of the human CYP2C subfamily

1994 • 534 citations

Ethnicity as a variable in epidemiological research

1994 • 530 citations

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

1994 • 500 citations

‘Cold SSCP’: a simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses

1993 • 335 citations

Genetic association between sensitivity to warfarin and expression of CYP2C9*3

1997 • 309 citations

Genetic analysis of the human cytochrome P450 CYP2C9 locus

1996 • 300 citations

The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase

1997 • 269 citations

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

2000 • 257 citations

Allelic Variants of Human Cytochrome P450 2C9: Baculovirus-Mediated Expression, Purification, Structural Characterization, Substrate Stereoselectivity, and Prochiral Selectivity of the Wild-Type and I359L Mutant Forms

1996 • 256 citations

Validation of Methods for CYP2C9 Genotyping: Frequencies of Mutant Alleles in a Swedish Population

1999 • 251 citations

Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: Regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes

1995 • 239 citations

A novel mutant variant of the CYP2D6 gene (CYP2D617) common in a black African population: association with diminished debrisoquine hydroxylase activity

1996 • 193 citations

Comparative Studies on the Catalytic Roles of Cytochrome P450 2C9 and Its Cys- and Leu-Variants in the Oxidation of Warfarin, Flurbiprofen, and Diclofenac by Human Liver Microsomes

1998 • 169 citations

Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele

1999 • 169 citations

Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359allele as low-Kmcatalysts of cyclophosphamide and ifosfamide activation

1997 • 132 citations

Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus

2000 • 130 citations

Genetic Polymorphism of the CYP2C Subfamily and Excessive Serum Phenytoin Concentration With Central Nervous System Intoxication

2000 • 121 citations

CYP2D6 phenotype ??? genotype relationships in African-Americans and Caucasians in Los Angeles

1998 • 110 citations

A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin

1999 • 100 citations

Enzymatic Determinants of the Substrate Specificity of CYP2C9: Role of B‘−C Loop Residues in Providing the π-Stacking Anchor Site for Warfarin Binding

1999 • 83 citations

Catalytic Activity of Three Variants (Ile, Leu, and Thr) at Amino Acid Residue 359 in Human CYP2C9 Gene and Simultaneous Detection Using Single-Strand Conformation Polymorphism Analysis

2000 • 71 citations

Phenotypic and genotypic investigations of a healthy volunteer deficient in the conversion of losartan to its active metabolite E-3174

1999 • 70 citations

The possession of the CYP2C9*3 allele is associated with low dose requirement of acenocoumarol

2000 • 52 citations

Highly sensitive and specific high-performance liquid chromatographic analysis of 7-hydroxywarfarin, a marker for human cytochrome P-4502C9 activity

1995 • 47 citations

Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid

1998 • 45 citations

Ethnic Differences in Drug Disposition and Response

1998 • 42 citations

High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data.

1998 • 39 citations

Targeted Antipeptide Antibodies to Cytochrome P450 2C18 Based on Epitope Mapping of an Inhibitory Monoclonal Antibody to P450 2C51

1997 • 35 citations

Mutagenicity of 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid treated with nitrite in the presence of alcohols

1996 • 33 citations

Structural flexibility and functional versatility of cytochrome P450 and rapid evolution

1996 • 32 citations

Oxygenated cytochrome P-450 as an intermediate in hydroxylation reactions

1971 • 28 citations

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