Pulsatile Stretch in Coronary Arteries Elicits Release of Endothelium-Derived Hyperpolarizing Factor

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

1994 • 1,704 citations

Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors

1996 • 1,226 citations

Acetylcholine releases endothelium‐derived hyperpolarizing factor and EDRF from rat blood vessels

1988 • 702 citations

Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.

1993 • 469 citations

Nitric Oxide Attenuates the Release of Endothelium-Derived Hyperpolarizing Factor

1996 • 433 citations

Characterization of endothelium‐derived hyperpolarizing factor as a cytochrome P450‐derived arachidonic acid metabolite in mammals.

1994 • 430 citations

Role of shear stress and endothelial prostaglandins in flow- and viscosity-induced dilation of arterioles in vitro.

1993 • 326 citations

Intracellular pH and Tyrosine Phosphorylation but Not Calcium Determine Shear Stress–Induced Nitric Oxide Production in Native Endothelial Cells

1996 • 287 citations

High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors.

1992 • 280 citations

Nitric oxide synthesized from L‐arginine regulates vascular tone in the coronary circulation of the rabbit

1989 • 279 citations

20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles

1996 • 278 citations

An Endogenous Cannabinoid as an Endothelium-Derived Vasorelaxant

1996 • 260 citations

Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed.

1992 • 253 citations

20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.

1993 • 250 citations

Membrane hyperpolarization is a mechanism of endothelium-dependent cerebral vasodilation

1990 • 239 citations

Prostacyclin production by cultured endothelial cell monolayers exposed to step increases in shear stress.

1985 • 232 citations

Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles

1996 • 224 citations

Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery

1997 • 214 citations

Cytochrome P450 mono‐oxygenase‐regulated signalling of Ca2+ entry in human and bovine endothelial cells.

1995 • 214 citations

Display of the characteristics of endothelium‐derived hyperpolarizing factor by a cytochrome P450‐derived arachidonic acid metabolite in the coronary microcirculation

1994 • 189 citations

A transferable, beta‐naphthoflavone‐inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells.

1996 • 174 citations

Anandamide, an endogenous cannabinomimetic eicosanoid: ‘Killing two birds with one stone’

1995 • 165 citations

Cytochrome P450 Metabolites of Arachidonic Acid as Intracellular Signaling Molecules in Vascular Tissue

1997 • 165 citations

Nitric oxide, ACh, and electrical and mechanical properties of canine arterial smooth muscle

1988 • 162 citations

Calcium-Dependent and Calcium-Independent Activation of the Endothelial NO Synthase

1997 • 150 citations

Stretch revealed three components in the hyperpolarization of guinea‐pig coronary artery in response to acetylcholine.

1993 • 141 citations

Calcium responses of endothelial cell monolayers subjected to pulsatile and steady laminar flow differ

1995 • 139 citations

Characterization and modulation of EDHF‐mediated relaxations in the rat isolated superior mesenteric arterial bed

1997 • 138 citations

Cytochrome P450‐dependent effects of bradykinin in the rat heart

1995 • 121 citations

Arachidonic acid-induced endothelial-dependent relaxations of canine coronary arteries: contribution of a cytochrome P-450-dependent pathway.

1987 • 115 citations

Inhibitors of the cytochrome P450‐mono‐oxygenase and endothelium‐dependent hyperpolarizations in the guinea‐pig isolated carotid artery

1996 • 109 citations

Evidence against a role of cytochrome P450‐derived arachidonic acid metabolites in endothelium‐dependent hyperpolarization by acetylcholine in rat isolated mesenteric artery

1997 • 107 citations

Endothelium-dependent hyperpolarization of smooth muscle cells in rabbit femoral arteries is not mediated by EDRF (nitric oxide)

1988 • 88 citations

Effects of cytochrome P450 inhibitors on EDHF‐mediated relaxation in the rat hepatic artery

1996 • 86 citations

Nature of endothelium-derived relaxing factor: are there two relaxing mediators?

1987 • 82 citations

Cholinergic modulation of apical Na+ channels in turtle colon: analysis of CDPC-induced fluctuations

1990 • 82 citations

Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein

1996 • 71 citations

Nature of Endothelium-Derived Relaxing Factor: Are There Two Relaxing Mediators?

1987 • 68 citations

Microsomal cytochrome P450-mediated liver and brain anandamide metabolism

1995 • 67 citations

RPR 106541, a novel, airways‐selective glucocorticoid: effects against antigen‐induced CD4⁺T lymphocyte accumulation and cytokine gene expression in the Brown Norway rat lung

1997 • 55 citations

N G-nitro-l-arginine antagonizes endothelium-dependent dilator responses by inhibiting endothelium-derived relaxing factor release in the isolated rabbit heart

1991 • 51 citations

Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors.

1994 • 45 citations

Photoelectric device for the recording of diameter changes of opaque and transparent blood vessels in vitro

1980 • 29 citations