Cytochrome P450 and the Individuality of Species

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

1998 • 7,572 citations

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

1996 • 2,895 citations

The Blind Watchmaker

1986 • 2,555 citations

Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome

1998 • 2,163 citations

A molecular timescale for vertebrate evolution

1998 • 1,945 citations

Evidence for a clade of nematodes, arthropods and other moulting animals

1997 • 1,581 citations

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

1999 • 1,263 citations

INSECT P450 ENZYMES

1999 • 979 citations

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

Neurobiology of the Caenorhabditis elegans Genome

1998 • 912 citations

THE INCIDENCE OF ALKAPTONURIA : A STUDY IN CHEMICAL INDIVIDUALITY.

1902 • 768 citations

Pigments of rat liver microsomes

1958 • 634 citations

The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

1996 • 584 citations

Evolution of the P450 gene superfamily:

1990 • 508 citations

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

1994 • 500 citations

Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.

1996 • 498 citations

RESPONSE: Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1999 • 478 citations

Genetic Linkage of Lung Cancer-Associated MspI Polymorphisms with Amino Acid Replacement in the Heme Binding Region of the Human Cytochrome P450IA1 Gene1

1991 • 449 citations

In Search of the First Flower: A Jurassic Angiosperm, Archaefructus , from Northeast China

1998 • 423 citations

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

1990 • 387 citations

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution

1997 • 378 citations

Sequence Analysis and Homology Modeling Suggest That Primary Congenital Glaucoma on 2p21 Results from Mutations Disrupting Either the Hinge Region or the Conserved Core Structures of Cytochrome P4501B1

1998 • 368 citations

Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1998 • 348 citations

PHYSIOLOGICAL IMPLICATIONS OF STEROL BIOSYNTHESIS IN YEAST

1995 • 318 citations

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

1990 • 304 citations

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

1995 • 293 citations

The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase

1997 • 269 citations

Comparative mapping of aflatoxin pathway gene clusters in Aspergillus parasiticus and Aspergillus flavus

1995 • 260 citations

Allelic Variants of Human Cytochrome P450 2C9: Baculovirus-Mediated Expression, Purification, Structural Characterization, Substrate Stereoselectivity, and Prochiral Selectivity of the Wild-Type and I359L Mutant Forms

1996 • 256 citations

The Role of Cytochrome P450 Monooxygenases in Plant-Insect Interactions

1996 • 252 citations

Reliable identification of large numbers of candidate SNPs from public EST data

1999 • 248 citations

Molecular cloning and functional heterologous expression of two alleles encoding (S)‐N‐methylcoclaurine 3′‐hydroxylase (CYP80B1), a new methyl jasmonate‐inducible cytochrome P‐450‐dependent mono‐oxygenase of benzylisoquinoline alkaloid biosynthesis

1998 • 204 citations

Animal evolution: the end of the intermediate taxa?

1999 • 193 citations

Serum parameters of Adriatic sturgeon Acipenser naccarii (Pisces: Acipenseriformes): effects of temperature and stress

1998 • 180 citations

Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele.

1997 • 178 citations

Molecular cloning and heterologous expression of a cDNA encoding berbamunine synthase, a C--O phenol-coupling cytochrome P450 from the higher plant Berberis stolonifera.

1995 • 171 citations

Diversity and Evolution of Plant P450 and P450-Reductases

1995 • 166 citations

The TRI11 Gene of Fusarium sporotrichioides Encodes a Cytochrome P-450 Monooxygenase Required for C-15 Hydroxylation in Trichothecene Biosynthesis

1998 • 142 citations

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

1997 • 109 citations

Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystin

1994 • 104 citations

Detection and characterization of novel polymorphisms in the CYP2E1 gene

1998 • 102 citations

Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype

1994 • 102 citations

An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians

1998 • 100 citations

Characterization of the gene cluster for biosynthesis of macrocyclic trichothecenes in Myrothecium roridum

1998 • 99 citations

Characterization of the alkane-inducible cytochrome P450 (P450alk) gene from the yeast Candida tropicalis: identification of a new P450 gene family

1989 • 91 citations

Characterization of the Critical Amino Acids of an Aspergillus parasiticus Cytochrome P-450 Monooxygenase Encoded by ordA That Is Involved in the Biosynthesis of Aflatoxins B ₁ , G ₁ , B ₂ , and G ₂

1998 • 88 citations

Detection of a CYP3A5 Allelic Variant: A Candidate for the Polymorphic Expression of the Protein?

1996 • 84 citations

CYP52(Cytochrome P450alk) Multigene Family inCandida maltosa:Identification and Characterization of Eight Members

1995 • 82 citations

Review Article Cytochromes P450 in fungi

1998 • 75 citations

Induction by alkaloids and phenobarbital of Family 4 Cytochrome P450s in Drosophila : evidence for involvement in host plant utilization

1998 • 68 citations

Archibald Garrod and the Individuality of Man

1993 • 66 citations

avnA, a gene encoding a cytochrome P-450 monooxygenase, is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus

1997 • 66 citations

CYP51-like gene of Mycobacterium tuberculosis actually encodes a P450 similar to eukaryotic CYP51.

1998 • 64 citations

Isozyme Function of n-Alkane-inducible Cytochromes P450 in Candida maltosa Revealed by Sequential Gene Disruption

1998 • 60 citations

A sterol biosynthetic pathway in Mycobacterium

1998 • 59 citations

Sterols of the phylum Zygomycota: Phylogenetic implications

1997 • 57 citations

Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.

1999 • 56 citations

Nitric Oxide Reductase Cytochrome P-450 Gene, CYP 55, of the Fungus Fusarium oxysporum Containing a Potential Binding-Site for FNR, the Transcription Factor Involved in the Regulation of Anaerobic Growth of Escherichia coli1

1994 • 39 citations

Identification of a New Cytochrome P450 Family, CYP45, from the Lobster,Homarus americanus,and Expression Following Hormone and Xenobiotic Exposures

1998 • 39 citations

A nonsense mutation in the cytochrome P450 CYP2D6 gene identified in a Caucasian with an enzyme deficiency

1995 • 27 citations

Presence and synthesis of cholesterol in stable staphylococcal L-forms

1979 • 26 citations

Archibald Garrod--and the Individuality of Man

1993 • 15 citations

Substitution at residue 473 confers progesterone 21-hydroxylase activity to cytochrome P450 2C2.

1995 • 14 citations

Genetics goes to Hollywood

1997 • 13 citations