Apoptosis in the embryo and tumorigenesis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Death in Embryonic Systems

1966 • 943 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Viral oncogenes

1985 • 605 citations

The MYC protein activates transcription of the alpha-prothymosin gene.

1991 • 589 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

The cell biology of transforming growth factor β

1990 • 537 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

THE EFFECT OF CELLS TRANSFERRED INTO THE MOUSE BLASTOCYST ON SUBSEQUENT DEVELOPMENT

1974 • 512 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Impairment of function in aging neutrophils is associated with apoptosis.

1993 • 467 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1991 • 412 citations

IN SITU NEUROBLASTOMAS: A CONTRIBUTION TO THE NATURAL HISTORY OF NEURAL CREST TUMORS.

1963 • 395 citations

Major Problems in Developmental Biology

1966 • 364 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.

1991 • 332 citations

Expression of bcl-2 in fetal tissues suggests a role in morphogenesis.

1993 • 320 citations

Apoptosis in metanephric development.

1992 • 310 citations

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

1989 • 300 citations

Differential expression of TGF β1, β2 and β3 genes during mouse embryogenesis

1991 • 296 citations

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.

1992 • 282 citations

Autocrine secretion of GM-CSF in acute myeloblastic leukemia

1986 • 280 citations

Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells.

1993 • 280 citations

bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells

1992 • 276 citations

Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells.

1986 • 271 citations

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis

1990 • 266 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle

1993 • 252 citations

Expression of p53 during mouse embryogenesis

1991 • 249 citations

Precursor lesions of Wilms tumor: Clinical and biological implications

1993 • 242 citations

Cytokine networks in the uteroplacental unit: Macrophages as pivotal regulatory cells

1989 • 240 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

Cell Death in Morphogenesis

1966 • 232 citations

Granulocyte-Macrophage Colony-Stimulating Factor: Pleiotropic Cytokine with Potential Clinical Usefulness

1990 • 227 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.

1993 • 214 citations

Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex

1986 • 210 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 195 citations

Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells

1993 • 194 citations

In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1.

1992 • 190 citations

Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.

1992 • 188 citations

Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk.

1992 • 187 citations

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice.

1992 • 181 citations

Cell death in the morphogenesis and teratogenesis of the heart

1975 • 178 citations

Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.

1993 • 177 citations

Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma.

1992 • 176 citations

The Morphologic Basis of Antibody Formation Development during the Neonatal Period

1959 • 160 citations

Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment.

1984 • 154 citations

Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death.

1993 • 152 citations

Hematopoiesis in young human embryos

1940 • 150 citations

Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells.

1993 • 147 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 145 citations

Expression of TGF-β isoforms during first trimester human embryogenesis

1990 • 139 citations

Cell death in embryogenesis

1981 • 138 citations

Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia

1990 • 138 citations

Fertilization of the Human Egg In Vitro

1983 • 131 citations

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.

1993 • 131 citations

The trophoblast as an integral component of a macrophage‐cytokine network

1993 • 127 citations

The kit receptor and its ligand, steel factor, as regulators of hemopoiesis.

1991 • 125 citations

The expression of T cell receptor-associated proteins during T cell ontogeny in man.

1989 • 122 citations

Induction of apoptosis--new targets for cancer chemotherapy.

1992 • 121 citations

Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53.

1993 • 118 citations

Human T cell antigen expression during the early stages of fetal thymic maturation.

1985 • 118 citations

The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis.

1990 • 113 citations

CD3‐mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin‐1, interleukin‐2, interferon‐γ and accessory cells

1993 • 113 citations

Cell-type-specific pattern of myc protooncogene expression in developing human embryos.

1985 • 111 citations

A subset of anti‐CD21 antibodies promote the rescue of germinal center B cells from apoptosis

1993 • 109 citations

Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia

1990 • 108 citations

RECONSTITUTION OF B AND T LYMPHOCYTE FUNCTION IN SEVERE COMBINED IMMUNODEFICIENCY DISEASE AFTER TRANSPLANTATION WITH THYMIC EPITHELIUM

1976 • 107 citations

Role of colony stimulating factor‐1 (CSF‐1) and other lympho‐hematopoietic growth factors in mouse pre‐implantation development

1991 • 106 citations

Cell redundancy in the zona-intact preimplantation mouse blastocyst: a light and electron microscope study of dead cells and their fate.

1974 • 102 citations

Immunohistochemical detection of p53 and bcl‐2 proteins in non‐Hodgkin's lymphoma

1993 • 101 citations

Ultrastructure of human yolk sac: Endoderm, mesenchyme, tubules and mesothelium

1969 • 100 citations

The implications of a unified theory of programmed cell death, polyamines, oxyradicals and histogenesis in the embryo.

1993 • 99 citations

Mechanism of programmed cell death in the blastocyst.

1989 • 98 citations

Ontogeny of human hematopoietic cells: analysis utilizing monoclonal antibodies.

1983 • 91 citations

Fatal Lymphoma after Transplantation of Cultured Thymus in Children with Combined Immunodeficiency Disease

1979 • 84 citations

Fetal hemopoiesis

1973 • 84 citations

Multiple cell cycle access to the apoptotic death programme in human neuroblastoma cells

1993 • 82 citations

The phosphoprotein p53 is down-regulated post-transcriptionally during embryogenesis in vertebrates

1988 • 76 citations

Studies on possible mechanisms of programmed cell death in the chick embryo

1970 • 75 citations

Human Foetal Haematopoiesis

1964 • 72 citations

The human foetal yolk sac

1969 • 70 citations

T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation.

1989 • 68 citations

Mutations of the p53 gene in B-cell lymphoblastic acute leukemia: a report on 60 cases.

1992 • 68 citations

Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture.

1992 • 67 citations

The Early Development of Morphology and Patterns of the Face in the Human Embryo

1985 • 67 citations

Role of platelet-derived growth factor in development of in vitro matured and in vitro fertilized bovine embryos

1993 • 65 citations

Analysis of expression of CD2, CD3, and T cell antigen receptor molecules during early human fetal thymic development.

1988 • 64 citations

Induction of apoptosis in cultured hepatocytes and in the regressing liver by transforming growth factor-β1 occurs without activation of an endonuclease

1992 • 64 citations

Human embryonic hemopoiesis: Control mechanisms underlying progenitor differentiation in vitro

1988 • 63 citations

Genetics of pattern formation and growth control

1991 • 58 citations

Transforming growth factor beta inhibits the proliferation of the blast cells of acute myeloblastic leukemia

1988 • 57 citations

Effects of transforming growth factor beta 1 on growth and apoptosis of human acute myelogenous leukemia cells.

1993 • 56 citations

Different bcl-2 protein expression in high-grade B-cell lymphomas derived from lymph node or mucosa-associated lymphoid tissue.

1991 • 55 citations

Thymic and peripheral apoptosis of antigen‐specific T cells might cooperate in establishing self tolerance

1993 • 54 citations

ANALYSIS OF PROLIFERATION AND DIFFERENTIATION OF FOETAL GRANULOCYTE‐MACROPHAGE PROGENITOR CELLS IN HAEMOPOIETIC TISSUE*

1973 • 52 citations

Glucocorticosteroids induce DNA fragmentation in human lymphoid leukemia cells

1988 • 49 citations

Inhibition of Programmed Cell Death in Mouse Embryonic Palate in Vitro by Cortisol and Phenytoin: Receptor Involvement and Requirement of Protein Synthesis

1983 • 48 citations

T-cell receptor delta gene recombination in common acute lymphoblastic leukemia: preferential usage of V delta 2 and frequent involvement of the J alpha cluster

1991 • 45 citations

Mutations of the p53 tumour suppressor gene in haematologic neoplasms

1992 • 44 citations

Involvement of the interleukin 2 pathway in the rearrangement and expression of both alpha/beta and gamma/delta T cell receptor genes in human T cell precursors.

1988 • 44 citations

The Fine Structure of Normal and Abnormal Human Embryos Developed in Culture

1983 • 38 citations

Trophectoderm in control of murine embryonal carcinoma.

1984 • 38 citations

T-cell receptor delta gene recombination in common acute lymphoblastic leukemia: preferential usage of V delta 2 and frequent involvement of the J alpha cluster

1991 • 35 citations

Rearrangement and expression of T-cell receptor delta genes in T-cell acute lymphoblastic leukemias

1989 • 34 citations

Expression of interleukins 1, 3, 6, stem cell factor and their receptors in acute leukemia blast cells and in normal peripheral lymphocytes and monocytes

1993 • 32 citations

Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours

1992 • 32 citations

Defective c-myc and c-myb RNA turnover in acute myeloid leukemia cells

1992 • 29 citations

Control of Apoptosis and Growth of Malignant T Lymphoma Cells by Lymph Node Stromal Cells

1993 • 28 citations

Hemopoiesis in the human yolk sac

1989 • 27 citations

Programmed cell death (apoptosis) in murine blastocysts: extracellular free-radicals, polyamines, and other cytotoxic agents.

1991 • 27 citations

The role of apoptosis in antibody-dependent cellular cytotoxicity

1993 • 27 citations

Molecular analysis of acute undifferentiated leukemia: two distinct subgroups at the DNA and RNA levels

1989 • 27 citations

Long‐term haemopoiesis in human fetal liver cell cultures

1984 • 24 citations

Cellular Composition of Human Fetal Bone Marrow

1982 • 22 citations

Antibodies to Sperm Surface Antigens and the c-myc Proto-oncogene Product Inhibit Early Embryonic Development in Mice1

1991 • 21 citations

Granulocyte-macrophage colonies in cultures of human fetal liver cells: morphologic and ultrastructural analysis of proliferation and differentiation.

1980 • 19 citations

1-ß-d-arabinosylcytosine and 5-azacytidine induce internucleosomal DNA fragmentation and cell death in thymocytes

1992 • 17 citations

Genetics of pattern formation and growth control

1992 • 15 citations

Zellbildung und Zelluntergang in Zentren sekund�rer Lymphfollikel der Maus

1966 • 14 citations

Differential responses of fetal, neonatal, and adult myelopoietic progenitors to interferon and tumor necrosis factor.

1994 • 9 citations

Early embryonal/fetal lymphopoietic ontogeny and leukemogenesis

1991 • 4 citations

Embryonic stem cells.

1992 • 1 citations