Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma.

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

A specific chromosomal abnormality in rhabdomyosarcoma

1987 • 326 citations

Gene losses in human tumours

1988 • 280 citations

Mechanisms of p53 loss in human sarcomas.

1990 • 273 citations

Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping

1987 • 273 citations

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors

1993 • 207 citations

Rhabdomyosarcoma in Children

1961 • 182 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.

1990 • 135 citations

Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.

1992 • 98 citations

Characterization of cell lines derived from xenografts of childhood rhabdomyosarcoma.

1987 • 82 citations

Cancer in the families of children with soft tissue sarcoma

1990 • 74 citations

The in vitro growth, heterotransplantation, and differentiation of a human rhabdomyosarcoma cell line.

1986 • 65 citations

In situ selection of a human rhabdomyosarcoma resistant to vincristine with altered beta-tubulins.

1985 • 46 citations

Development of resistance to vincristine in a childhood rhabdomyosarcoma growing in immune‐deprived mice

1981 • 17 citations