Granulocyte-Macrophage Colony-Stimulating Factor: Pleiotropic Cytokine with Potential Clinical Usefulness

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

There is more than one interleukin 1

1986 • 1,226 citations

The Granulocyte-Macrophage Colony-Stimulating Factors

1985 • 1,007 citations

The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors

1986 • 901 citations

Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis

1988 • 845 citations

Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3

1986 • 823 citations

Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Hematopoietic Reconstitution after High-Dose Chemotherapy and Autologous Bone Marrow Transplantation

1988 • 779 citations

Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.

1986 • 733 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, P cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity

1983 • 702 citations

Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Chemotherapy-Induced Myelosuppression

1988 • 689 citations

Effects of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor in Patients with Myelodysplastic Syndromes

1987 • 653 citations

Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment

1987 • 636 citations

Effect of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor on Myelopoiesis in the Acquired Immunodeficiency Syndrome

1987 • 633 citations

Purification and properties of colony-stimulating factor from mouse lung-conditioned medium.

1977 • 624 citations

Hematopoietic growth factors.

1987 • 621 citations

GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR EXPANDS THE CIRCULATING HAEMOPOIETIC PROGENITOR CELL COMPARTMENT IN MAN

1988 • 585 citations

Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator

1985 • 566 citations

Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells.

1988 • 565 citations

Recombinant human TNF induces production of granulocyte–monocyte colony-stimulating factor

1986 • 528 citations

Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells.

1987 • 523 citations

Biologic properties in vitro of a recombinant human granulocyte- macrophage colony-stimulating factor

1986 • 458 citations

Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte—macrophage colony stimulating factor

1984 • 451 citations

Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts.

1987 • 408 citations

Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF

1986 • 405 citations

Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.

1986 • 396 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

Human CSF-1: Molecular Cloning and Expression of 4-kb cDNA Encoding the Human Urinary Protein

1987 • 381 citations

Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation

1987 • 377 citations

Human Recombinant Granulocyte-Macrophage Colony-Stimulating Factor: A Multilineage Hematopoietin

1985 • 374 citations

Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies.

1980 • 341 citations

Human GM-CSF primes neutrophils for enhanced oxidative metabolism in response to the major physiological chemoattractants

1987 • 333 citations

Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils

1986 • 331 citations

Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor.

1985 • 314 citations

Hierarchical down-modulation of hemopoietic growth factor receptors

1985 • 314 citations

Rapid Cytoplasmic Turnover of c-myc mRNA: Requirement of the 3′ Untranslated Sequences

1987 • 302 citations

Phase I/II study of recombinant human granulocyte-macrophage colony- stimulating factor in aplastic anemia and myelodysplastic syndrome

1988 • 301 citations

Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells.

1987 • 299 citations

Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor.

1986 • 297 citations

Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes--a phase I/II trial

1989 • 293 citations

Identification of lactoferrin as the granulocyte-derived inhibitor of colony-stimulating activity production.

1978 • 293 citations

Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes.

1986 • 284 citations

Hemopoietic responses in mice injected with purified recombinant murine GM-CSF.

1987 • 284 citations

Monocyte-Derived Human B-Cell Growth Factor Identified as Interferon-β ₂ (BSF-2, IL-6)

1988 • 281 citations

Autocrine secretion of GM-CSF in acute myeloblastic leukemia

1986 • 280 citations

The effects of GM-CSF and G-CSF in promoting growth of clonogenic cells in acute myeloblastic leukemia

1987 • 273 citations

Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity

1985 • 273 citations

Use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies

1988 • 271 citations

Control of hemopoiesis by a bone marrow stromal cell clone: lipopolysaccharide- and interleukin-1-inducible production of colony- stimulating factors

1987 • 263 citations

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.

1985 • 262 citations

Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor.

1987 • 259 citations

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes.

1985 • 257 citations

Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor.

1987 • 254 citations

Characterization and Biological Effects of Recombinant Human Erythropoietin

1986 • 250 citations

Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation.

1988 • 247 citations

Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: interleukin 3 and granulocyte/macrophage-colony-stimulating factor are specific for early developmental stages.

1988 • 239 citations

Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia.

1987 • 239 citations

Additive effects of interleukin 1 and tumour necrosis factor-alpha on the accumulation of the three granulocyte and macrophage colony-stimulating factor mRNAs in human endothelial cells.

1987 • 238 citations

Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin.

1988 • 238 citations

The Human Gene Encoding GM-CSF Is at 5q21-q32, the Chromosome Region Deleted in the 5q ^- Anomaly

1985 • 237 citations

The Molecular Control of Blood Cell Development

1987 • 234 citations

Evidence for the Involvement of GM-CSF and FMS in the Deletion (5q) in Myeloid Disorders

1986 • 233 citations

Stimulation by Granulocyte-Macrophage Colony-Stimulating Factor of Leishmania Tropica Killing by Macrophages

1979 • 227 citations

GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor

1988 • 227 citations

Effects of recombinant human GM-CSF on proliferation of clonogenic cells in acute myeloblastic leukemia

1986 • 223 citations

Human granulocyte-monocyte colony-stimulating factor and interleukin 3 stimulate monocyte cytotoxicity through a tumor necrosis factor- dependent mechanism

1988 • 221 citations

GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism

1988 • 219 citations

Biosynthetic human GM-CSF modulates the number and affinity of neutrophil f-Met-Leu-Phe receptors.

1986 • 218 citations

Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma.

1987 • 215 citations

The effects of three recombinant growth factors, IL-3, GM-CSF, and G- CSF, on the blast cells of acute myeloblastic leukemia maintained in short-term suspension culture

1987 • 215 citations

Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor.

1987 • 212 citations

Biosynthetic (recombinant) human granulocyte-macrophage colony- stimulating factor: effect on normal bone marrow and leukemia cell lines

1986 • 203 citations

Characterization of the human granulocyte-macrophage colony-stimulating factor receptor.

1988 • 202 citations

Granulocyte-macrophage colony-stimulating factor induces cytokine secretion by human polymorphonuclear leukocytes.

1989 • 201 citations

Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor.

1985 • 195 citations

Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages.

1987 • 194 citations

Chemotactic activity of human recombinant granulocyte-macrophage colony-stimulating factor.

1987 • 194 citations

Effects of Bacterially Synthesized Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Patients with Advanced Malignancy

1989 • 194 citations

Activation of granulocyte cytotoxic function by purified mouse colony-stimulating factors.

1983 • 193 citations

Granulocyte-macrophage colony-stimulating factor enhances neutrophil function in acquired immunodeficiency syndrome patients.

1988 • 193 citations

Recombinant human TNF alpha stimulates production of granulocyte colony- stimulating factor

1987 • 189 citations

Human granulocyte-macrophage colony-stimulating factor and other cytokines prime human neutrophils for enhanced arachidonic acid release and leukotriene B4 synthesis.

1988 • 189 citations

Stimulation of Myelopoiesis in Patients with Aplastic Anemia by Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

1988 • 188 citations

Leukotriene production in human neutrophils primed by recombinant human granulocyte/macrophage colony-stimulating factor and stimulated with the complement component C5A and FMLP as second signals.

1988 • 185 citations

Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model.

1987 • 179 citations

Human granulocyte-macrophage colony-stimulating factor induces expression of the tumor necrosis factor gene by the U937 cell line and by normal human monocytes.

1987 • 178 citations

Structure-function studies of a colony stimulating factor (CSF-1).

1982 • 175 citations

Keratinocyte growth regulation by the products of immune cells.

1988 • 172 citations

Expression of the macrophage-specific colony-stimulating factor in human monocytes treated with granulocyte-macrophage colony-stimulating factor

1987 • 169 citations

Effects of recombinant IL-3, GM-CSF, and G-CSF on proliferation of leukemic clonogenic cells in short-term and long-term cultures.

1987 • 166 citations

Granulocyte/macrophage colony-stimulating factor induces interleukin 1 production by human polymorphonuclear neutrophils.

1988 • 165 citations

Production of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor by human mononuclear cells stimulated with granulocyte- macrophage colony-stimulating factor [see comments]

1988 • 165 citations

Recombinant human GM-CSF induces leukocytosis and activates peripheral blood polymorphonuclear neutrophils in nonhuman primates

1987 • 164 citations

Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor.

1986 • 164 citations

Effects of recombinant human granulocyte and macrophage colony-stimulating factors on signal transduction pathways in human granulocytes.

1987 • 160 citations

Assignment of CSF-1 to 5q33.1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders.

1987 • 158 citations

Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release.

1988 • 158 citations

Synergism between recombinant growth factors, GM-CSF and G-CSF, acting on the blast cells of acute myeloblastic leukemia [published erratum appears in Blood 1987 Jul;70(1):339]

1987 • 156 citations

Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity.

1985 • 156 citations

Colony-Stimulating Factors and Host Defense

1989 • 155 citations

Interleukin 1 stimulates T lymphocytes to produce granulocyte-monocyte colony-stimulating factor.

1988 • 150 citations

Characterization of the cell surface receptor for granulocyte-macrophage colony-stimulating factor.

1986 • 149 citations

Specific binding of radioiodinated granulocyte-macrophage colony-stimulating factor to hemopoietic cells.

1985 • 149 citations

In vitro actions on hemopoietic cells of recombinant murine GM‐CSF purified after production in Escherichia coli: Comparison with purified native GM‐CSF

1986 • 149 citations

Clonal analysis of progenitor cell commitment to granulocyte or macrophage production

1982 • 145 citations

Kinetics of human hemopoietic cells after in vivo administration of granulocyte-macrophage colony-stimulating factor.

1989 • 144 citations

Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor.

1986 • 141 citations

Recombinant murine granulocyte macrophage colony-stimulating factor has megakaryocyte colony-stimulating activity and augments megakaryocyte colony stimulation by interleukin 3.

1987 • 139 citations

Effects of recombinant GM-CSF on the blast cells of acute myeloblastic leukemia

1986 • 139 citations

Localization of the G-CSF gene on chromosome 17 proximal to the breakpoint in the t(15;17) in acute promyelocytic leukemia

1987 • 135 citations

In vitro modification of human immunodeficiency virus infection by granulocyte-macrophage colony-stimulating factor and gamma interferon.

1986 • 133 citations

The human genes for GM-CSF and IL 3 are closely linked in tandem on chromosome 5

1988 • 129 citations

Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene.

1988 • 129 citations

The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters.

1985 • 129 citations

Primary human myeloid leukemia cells: comparative responsiveness to proliferative stimulation by GM-CSF or G-CSF and membrane expression of CSF receptors.

1987 • 124 citations

Similar molecular properties of granulocyte-macrophage colony-stimulating factors produced by different mouse organs in vitro and in vivo.

1979 • 119 citations

Increased myelopoiesis during Leishmania major infection in mice: generation of 'safe targets', a possible way to evade the effector immune mechanism.

1986 • 115 citations

Granulocyte/macrophage colony-stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony-stimulating factor

1988 • 112 citations

Demonstration of burst-promoting activity of recombinant human GM-CSF on circulating erythroid progenitors using an assay involving the delayed addition of erythropoietin

1985 • 112 citations

Erythropoietin: Gene Cloning, Protein Structure, and Biological Properties

1986 • 110 citations

Keratinocyte Derived T-Cell Growth Factor (KTGF) Is Identical to Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)

1988 • 102 citations

The effect of recombinant GM-CSF on the recovery of monkeys transplanted with autologous bone marrow

1987 • 102 citations

Monocyte-macrophage-derived acidic isoferritins: normal feedback regulators of granulocyte-macrophage progenitor cells in vitro

1982 • 100 citations

Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor.

1989 • 98 citations

Synergistic and antagonistic effects of recombinant human interleukin (IL) 3, IL-1 alpha, granulocyte and macrophage colony-stimulating factors (G-CSF and M-CSF) on the growth of GM-CSF-dependent leukemic cell lines.

1987 • 97 citations

Analysis of Ia antigen expression in macrophages derived from bone marrow cells cultured in granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating factor

1988 • 95 citations

Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages

1988 • 90 citations

Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: functional analysis based upon the activities of interspecies hybrid growth factors.

1989 • 89 citations

Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro

1987 • 87 citations

Activation and proliferation signals in murine macrophages: Stimulation of glucose uptake by hemopoietic growth factors and other agents

1988 • 87 citations

Purification and characterization of a human T-lymphocyte-derived granulocyte-macrophage colony-stimulating factor

1981 • 87 citations

Histamine-producing cell-stimulating activity. Interleukin 3 and granulocyte-macrophage colony-stimulating factor induce de novo synthesis of histidine decarboxylase in hemopoietic progenitor cells.

1987 • 83 citations

Recovery from severe hematopoietic suppression using recombinant human granulocyte-macrophage colony-stimulating factor.

1988 • 83 citations

Activation and proliferation signals in murine macrophages: Stimulation of Na⁺, K⁺‐ATPase activity by hemopoietic growth factors and other agents

1988 • 82 citations

Granulocyte-macrophage colony-stimulating factor modulates the excitation-response coupling sequence in human neutrophils.

1988 • 82 citations

Keratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages.

1988 • 79 citations

Interferon gamma and granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small-cell lung cancer cell lines.

1986 • 78 citations

Role of carbohydrate in the function of human granulocyte-macrophage colony-stimulating factor

1987 • 78 citations

Stimulation of guanylate cyclase activity and reduction of adenylate cyclase activity by granulocyte-macrophage colony-stimulating factor in human blood neutrophils.

1988 • 71 citations

Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF).

1987 • 71 citations

In vitro expression of colony-stimulating factor genes by human acute myeloblastic leukemia cells.

1988 • 70 citations

Platelet-activating factor production in human neutrophils by sequential stimulation with granulocyte-macrophage colony-stimulating factor and the chemotactic factors C5A or formyl-methionyl-leucyl-phenylalanine.

1989 • 67 citations

Structure-function studies of human granulocyte-macrophage colony-stimulating factor. Identification of residues required for activity.

1988 • 66 citations

Effects of GM‐CSF deprivation on precursors of granulocytes and macrophages

1982 • 65 citations

Clonal heterogeneity in colony stimulating factor production by murine T lymphocytes

1985 • 65 citations

Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin E.

1988 • 61 citations

The effect of colony stimulating factor on the synthesis of ribonucleic acid by mouse bone marrow cells in vitro

1977 • 60 citations

1,25-Dihydroxyvitamin D3 modulates the expression of a lymphokine (granulocyte-macrophage colony-stimulating factor) posttranscriptionally.

1988 • 58 citations

In vivo control of differentiation of myeloid leukemic cells by recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3

1988 • 58 citations

Monocyte-conditioned medium and interleukin 1 induce granulocyte-macrophage colony-stimulating factor production in the adherent cell layer of murine bone marrow cultures.

1986 • 58 citations

Rat Tracheal Epithelial Cells Produce Granulocyte/Macrophage Colony-stimulating Factor

1990 • 58 citations

Assignment of the GM-CSF, CSF-1, and FMS Genes to Human Chromosome 5 Provides Evidence for Linkage of a Family of Genes Regulating Hematopoiesis and for Their Involvement in the Deletion (5q) in Myeloid Disorders

1986 • 56 citations

Colony-forming cells and colony-stimulating activity during listeriosis in genetically resistant or susceptible mice

1986 • 55 citations

Granulocyte-macrophage colony stimulating factor produced by cloned L3T4a+, class II-restricted T cells induces HT-2 cells to proliferate.

1987 • 55 citations

Response of resident murine peritoneal macrophages to in vivo administration of granulocyte-macrophage colony-stimulating factor.

1988 • 55 citations

Growth response of human myeloid leukemia cells to colony-stimulating factors.

1988 • 55 citations

Internalisation and recycling of the granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) receptor on a murine myelomonocytic leukemia

1987 • 51 citations

Mechanism of Inhibition of Granulopoiesis by Ethanol

1984 • 50 citations

Lactoferrin acts on I-A and I-E/C antigen+ subpopulations of mouse peritoneal macrophages in the absence of T lymphocytes and other cell types to inhibit production of granulocyte-macrophage colony stimulatory factors in vitro.

1984 • 50 citations

Structural homologies among the hemopoietins.

1986 • 49 citations

The Role of the Colony‐Stimulating Factors in Resistance to Acute Infections

1987 • 49 citations

Production of granulocyte-macrophage colony-stimulating factor by Abelson virus-induced tumorigenic mast cell lines

1986 • 48 citations

Effects of human colony-stimulating factor on the uptake and destruction of a pathogenic parasite (Trypanosoma cruzi) by human neutrophils.

1986 • 46 citations

Independent regulation of granulocyte-macrophage colony-stimulating factor and multi-lineage colony-stimulating factor production in T lymphocyte clones.

1986 • 46 citations

Osteotropic agents induce the differential secretion of granulocyte-macrophage colony-stimulating factor by the osteoblast cell line MC3T3-E1

1989 • 45 citations

Granulocyte macrophage‐colony stimulating factor stimulates the synthesis of membrane and nuclear proteins in murine neutrophils

1983 • 43 citations

Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Patients with Myelodysplastic Syndromes – a Phase-I/II Trial

1988 • 42 citations

Constitutive production of leukemia differentiation, colony- stimulating, erythroid burst-promoting, and pluripoietic factors by a human hepatoma cell line: characterization of the leukemia differentiation factor

1985 • 41 citations

Colony-stimulating factor (CSF) controls proliferation of CSF-dependent cells by acting during the G1 phase of the cell cycle.

1984 • 38 citations

Biochemical characterization of regulatory factors derived from T cell hybridomas and spleen cells. I. Separation of T cell growth factor and T cell replacing factor from granulocyte-macrophage colony-stimulating factor.

1982 • 38 citations

Patterns of acute myeloid leukemia colony growth in response to recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF).

1987 • 36 citations

Enhancement of neutrophil function by granulocyte-macrophage colony- stimulating factor involves recruitment of a less responsive subpopulation

1988 • 36 citations

Molecular control of granulocyte and macrophage production.

1985 • 32 citations

Effect of human recombinant granulocyte/macrophage colony-stimulating factor and native granulocyte colony-stimulating factor on clonogenic leukemic blast cells.

1987 • 31 citations

Hemopoietic growth factors and their interactions with specific receptors

1987 • 30 citations

Production of granulocyte-macrophage colony-stimulating factor by primary cultures of unstimulated rat microvascular endothelial cells

1988 • 30 citations

Biologic effects of in vitro X-irradiation of murine long-term bone marrow cultures on the production of granulocyte-macrophage colony-stimulating factors.

1985 • 28 citations

Granulocyte/macrophage colony-stimulating factor from mouse lung conditioned medium. Purification of multiple forms and radioiodination

1986 • 28 citations

Establishment of a cell line of gallbladder carcinoma (GBK-1) producing human colony stimulating factor.

1986 • 26 citations

Specificity of Action of Colony‐Stimulating Factors in the Differentiation of Granulocytes and Macrophages

1986 • 26 citations

Myeloperoxidase and oncogene expression in GM-CSF induced bone marrow differentiation.

1988 • 25 citations

Human gamma interferon enhances release from phytohemagglutinin- stimulated T4+ lymphocytes of activities that stimulate colony formation by granulocyte-macrophage, erythroid, and multipotential progenitor cells

1986 • 24 citations

The differential inhibition of hemopoietic growth factor activity by cytotoxins and interferon-gamma.

1987 • 24 citations

Human granulocyte-macrophage colony-stimulating factor purified from a Hodgkin's tumor cell line

1986 • 24 citations

Haemopoietic growth factors

1988 • 23 citations

Specificity of lithium (Li+) to enhance the production of colony stimulating factor (GM-CSF) from mitogen-stimulated lymphocytes in vitro

1984 • 22 citations

Human trophoblasts: cellular source of colony-stimulating activity in placental tissue

1982 • 21 citations

Biochemical characterization of regulatory factors derived from T cell hybridomas and spleen cells. II. Evidence for glycosylation of T cell growth factor, T cell replacing factor, and granulocyte-macrophage colony-stimulating factor.

1982 • 21 citations

Purified murine granulocyte/macrophage progenitor cells express a high-affinity receptor for recombinant murine granulocyte/macrophage colony-stimulating factor.

1988 • 21 citations

The colony-stimulating factors and myeloid leukemia

1995 • 21 citations

Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor

1989 • 20 citations

Viral infection of vascular endothelial cells alters production of colony-stimulating activity.

1985 • 20 citations

A Model for the Regulation of Myelopoiesis by Specific Factors

1986 • 19 citations

Colony-Stimulating Factor Producing Carcinoma of the Gallbladder

1986 • 19 citations

Regulation of the colony-stimulating activity produced by a murine marrow-derived cell line (H-1).

1982 • 19 citations

Induction of granulocyte-macrophage colony-stimulating activity in mouse skin by inflammatory agents and tumor promoters.

1983 • 19 citations

Lymphokines: from conjecture to the clinic.

1986 • 18 citations

Secretion of Colony-Stimulating Factors by Human Monocytes and Bone Marrow Cells After In Vitro Treatment With Biological Response Modifiers

1985 • 16 citations

Induction of granulocyte-macrophage colony-stimulating factor by lipopolysaccharide and anti-immunoglobulin M-stimulated murine B cell lines.

1987 • 16 citations

Modulation of proto-oncogene expression by colony stimulating factors

1987 • 16 citations

Actions of Hematopoietic Colony-Stimulating Factors in vivo and in vitro

1987 • 15 citations

Ability of Post-endotoxin serum from BCG-infected mice to induce nonspecific resistance and stimulation of granulopoiesis

1983 • 15 citations

Generation of mature CD3+ and T cell receptor (TCR) + T cells from a leukemic analogue of the putative human stem cell by T cell conditioned medium containing IL-3, IL-2, and GM-CSF.

1988 • 14 citations

Augmented production of colony-stimulating factor in C3H/HeN mice immunized with Nocardia rubra cell wall skeleton

1986 • 14 citations

X‐ray‐induced production of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) by mouse spleen cells in culture

1980 • 14 citations

Granulocyte-macrophage colony-stimulating factor in the sera of Schistosoma japonicum-infected mice

1985 • 13 citations

Hemopoietic colony stimulating factors

1988 • 12 citations

[43] Murine granulocyte-macrophage colony-stimulating factor

1985 • 12 citations

The effect of lipopolysaccharide on the production of GM-EA, GM-CSA, and PGE2 by human monocyte-derived lipid-containing macrophages.

1988 • 12 citations

Enhancement of colony‐stimulating‐factor–dependent clonal growth of murine macrophage progenitors and their phagocytic activity by retinoic acid

1985 • 11 citations

Human bladder carcinoma cell line HTB9, which secretes a factor to stimulate clonogenic leukemic blast growth, expresses the granulocyte-macrophage colony-stimulating factor gene.

1987 • 11 citations

Antigen-Specific Production of Colony-Stimulating Factors by Listeria monocytogenes-Immune, L3T4-Positive Cells

1988 • 10 citations

Effect of plasmacytoma cells on the production of granulocyte-macrophage colony-stimulating activity (GM-CSA) in the spleen of tumor-bearing mice.

1987 • 9 citations

Enhancement of neutrophil‐mediated phagocytosis by human granulocyte‐macrophage colony‐stimulating factor demonstrated using a novel mathematical model

1987 • 9 citations

Early Hemopoietic Differentiation: The Action of Multi‐CSF Is Complemented by Lineage Specific Growth Factors

1987 • 8 citations

A colony-stimulating-factor-producing cell line derived from mouse bone marrow cells transfected with adenovirus DNA.

1983 • 7 citations

Partial purification and characterization of a colony-stimulating factor secreted by a T lymphocyte clone.

1983 • 7 citations

Stimulation of oxidative metabolism of granulocytes by recombinant granulocyte-macrophage-colony-stimulating-factor and a conditioned medium of a urinary bladder carcinoma cell line

1987 • 6 citations

Endogenous inhibitors of human granulocyte/macrophage colony forming cells in vitro are inactivated by free radical scavengers

1986 • 6 citations

Granulocyte-macrophage colony-stimulating factor produced by splenic T lymphocytes of mice infected with Schistosoma japonicum

1986 • 6 citations

Isolation of cDNAs encoding human and gibbon GM-CSF.

1985 • 6 citations

The kinetics of s phase entry by FMP2.1: Effect of il‐3 and gm‐csf receptor expression and ligand affinity

1988 • 6 citations

Granulocyte-macrophage colony-stimulating factor enhances the production of eosinophil chemotactic lymphokine by egg-associated granulomas of Schistosoma japonicum-infected mice

1987 • 6 citations

The in vitro autocrine secretion of CSFs alone does not account for the longterm growth of murine myeloid leukemic cells in suspension cultures

1985 • 5 citations

Synergistic action of lipopolysaccharide and tumor-promoting phorbol esters: two-signal requirement for colony-stimulating factor production by murine bone marrow cells.

1986 • 4 citations

Haemopoietic Growth Factors: Structure and Receptor Interactions

1985 • 3 citations

Regulation of the production of granulocyte‐macrophage colony‐stimulating factor by macrophage‐like tumour cell lines

1985 • 3 citations

Molecular properties of a granulocyte/macrophage colony-stimulating factor obtained from the serum-free culture of Yoshida sarcoma cell Line YSSF-212T.

1983 • 2 citations

Effect of various immunomodulators on the production of granulocyte/macrophage colony-stimulating factor (GM-CSF) in mouse spleen cell cultures.

1983 • 2 citations

Purified human transferrin and "transferrin" released from sorted T8+ lymphocytes suppress release of granulocyte-macrophage colony-stimulating factors from sorted T4+ lymphocytes stimulated by phytohemagglutinin.

1986 • 2 citations

Effect of surgery on granulocyte/macrophage colony‐stimulating factor

1978 • 1 citations