PKR, apoptosis and cancer

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Initiation of Protein Synthesis in Eukaryotic Cells

1996 • 715 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 • 640 citations

The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

1997 • 600 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

A conserved double-stranded RNA-binding domain.

1992 • 540 citations

Translational Regulation of Yeast GCN4

1997 • 533 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

PACT, a protein activator of the interferon-induced protein kinase, PKR

1998 • 442 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1997 • 394 citations

Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR

1991 • 391 citations

The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.

1993 • 383 citations

Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase

1998 • 380 citations

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappa B

1997 • 353 citations

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

1998 • 347 citations

Alternative Translation of Human Fibroblast Growth Factor 2 mRNA Occurs by Internal Entry of Ribosomes

1995 • 332 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

The Interferon-induced Double-Stranded RNA-Activated Protein Kinase Induces Apoptosis

1994 • 322 citations

Protein Phosphorylation Controls Translation Rates

1989 • 303 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

1995 • 288 citations

The eIF‐2α kinases and the control of protein synthesis ¹

1996 • 287 citations

Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.

1995 • 283 citations

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

1990 • 281 citations

Structure of the dsRNA binding domain of E. coli RNase III.

1995 • 279 citations

Elongation factor 1α, translation and the cytoskeleton

1995 • 273 citations

NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5.

1995 • 262 citations

Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2α Kinases PKR and GCN2

1998 • 255 citations

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI.

1992 • 243 citations

Expression of the bcl‐2 gene family in normal and malignant breast tissue: Low bax‐α expression in tumor cells correlates with resistance towards apoptosis

1995 • 242 citations

2-Aminopurine Selectively Inhibits the Induction of β-Interferon, c- fos , and c- myc Gene Expression

1988 • 233 citations

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

1993 • 227 citations

2 The Pathway and Mechanism of Eukaryotic Protein Synthesis

1996 • 225 citations

Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR

1997 • 223 citations

Blockage of NF-κB Signaling by Selective Ablation of an mRNA target by 2-5A Antisense Chimeras

1994 • 217 citations

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.

1994 • 215 citations

Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein.

1991 • 208 citations

PKR—A protein kinase regulated by double-stranded RNA

1997 • 207 citations

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system.

1991 • 207 citations

The Double Stranded RNA-Activated Protein Kinase Induced by Interferon: dsRNA-PK

1989 • 202 citations

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.

1996 • 192 citations

Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells

1997 • 192 citations

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.

1987 • 181 citations

The proto‐oncogene/translation factor eIF4E: A survey of its expression in breast carcinomas

1995 • 180 citations

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.

1992 • 176 citations

Elongation factor-1α gene determines susceptibility to transformation

1992 • 172 citations

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.

1996 • 171 citations

Mechanism of interferon action: Identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2α protein kinase

1992 • 170 citations

A Model for the Double-stranded RNA (dsRNA)-dependent Dimerization and Activation of the dsRNA-activated Protein Kinase PKR

1997 • 169 citations

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.

1995 • 165 citations

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.

1990 • 164 citations

Malignant transformation by overproduction of translation initiation factor eIF4G.

1997 • 163 citations

PDGF2/c-sis mRNA Leader Contains a Differentiation-linked Internal Ribosomal Entry Site (D-IRES)

1997 • 162 citations

The 58,000-Dalton Cellular Inhibitor of the Interferon-Induced Double-Stranded RNA-Activated Protein Kinase (PKR) Is a member of the Tetratricopeptide Repeat Family of Proteins

1994 • 162 citations

Clotrimazole inhibits cell proliferation in vitro and in vivo

1995 • 162 citations

Mechanism of Interferon Action

1996 • 161 citations

Oncogenes and tumor suppressor genes

1994 • 155 citations

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo.

1995 • 147 citations

Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection

1996 • 144 citations

Elongation factor-1α is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma

1996 • 144 citations

Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma

1997 • 143 citations

Mutants of the RNA-Dependent Protein Kinase (PKR) Lacking Double-Stranded RNA Binding Domain I Can Act as Transdominant Inhibitors and Induce Malignant Transformation

1995 • 139 citations

The Translation Initiation Factor eIF3-p48 Subunit Is Encoded byint-6, a Site of Frequent Integration by the Mouse Mammary Tumor Virus Genome

1997 • 137 citations

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins.

1994 • 136 citations

Calcium Depletion from the Endoplasmic Reticulum Activates the Double-stranded RNA-dependent Protein Kinase (PKR) to Inhibit Protein Synthesis

1995 • 134 citations

Translational enhancement of FGF-2 by eIF-4 factors, and alternate utilization of CUG and AUG codons for translation initiation.

1995 • 131 citations

Translation factors as effectors of cell growth and tumorigenesis

1993 • 128 citations

Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA

1997 • 128 citations

Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.

1988 • 126 citations

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.

1995 • 126 citations

Activation of the Double-stranded RNA-regulated Protein Kinase by Depletion of Endoplasmic Reticular Calcium Stores

1995 • 126 citations

Depletion of intracellular Ca ²⁺ stores, phosphorylation of eIF2α, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole

1998 • 126 citations

The Apoptosis Pathway Triggered by the Interferon-Induced Protein Kinase PKR Requires the Third Basic Domain, Initiates Upstream of Bcl-2, and Involves ICE-like Proteases1

1997 • 124 citations

The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.

1994 • 122 citations

Regulation of translation and cell growth by eIF-4E

1994 • 121 citations

Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.

1992 • 121 citations

The Vaccinia Virus E3L Gene Product Interacts with both the Regulatory and the Substrate Binding Regions of PKR: Implications for PKR Autoregulation

1998 • 118 citations

Structural Requirements for Double-Stranded RNA Binding, Dimerization, and Activation of the Human eIF-2α Kinase DAI in Saccharomyces cerevisiae

1995 • 116 citations

Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2α protein kinase from human cells

1992 • 116 citations

Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase.

1994 • 114 citations

Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells.

1996 • 112 citations

Autophosphorylation Sites Participate in the Activation of the Double-Stranded-RNA-Activated Protein Kinase PKR

1996 • 110 citations

Oncogenic ras induces an inhibitor of double-stranded RNA-dependent eukaryotic initiation factor 2 alpha-kinase activation

1992 • 109 citations

Double-Stranded RNA-Independent Dimerization of Interferon-Induced Protein Kinase PKR and Inhibition of Dimerization by the Cellular P58^IPK Inhibitor

1998 • 109 citations

Induction of the death-promoting genebax-? sensitizes cultured breast-cancer cells to drug-induced apoptosis

1996 • 109 citations

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.

1995 • 109 citations

Transcription Stimulation of the Fas-encoding Gene by Nuclear Factor for Interleukin-6 Expression upon Influenza Virus Infection

1995 • 103 citations

The molecular chaperone hsp40 regulates the activity of P58 ^IPK , the cellular inhibitor of PKR

1997 • 103 citations

Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase.

1992 • 101 citations

Rapid modulation of the apoptosis regulatory genes, bcl-2 and bax by prolactin in rat Nb2 lymphoma cells.

1996 • 97 citations

Interaction of the Interferon-Induced PKR Protein Kinase with Inhibitory Proteins P58^IPK and Vaccinia Virus K3L Is Mediated by Unique Domains: Implications for Kinase Regulation

1996 • 96 citations

The regulation of the protein kinase PKR by RNA

1996 • 94 citations

The eukaryotic initiation factor 2-associated 67-kDa polypeptide (p67) plays a critical role in regulation of protein synthesis initiation in animal cells.

1992 • 94 citations

Specific Mutations Near the Amino Terminus of Double-stranded RNA-dependent Protein Kinase (PKR) Differentially Affect Its Double-stranded RNA Binding and Dimerization Properties

1996 • 87 citations

A cis-acting element in the BCL-2 gene controls expression through translational mechanisms.

1996 • 85 citations

Regulation of Interferon-Induced Protein Kinase PKR: Modulation of P58^IPK Inhibitory Function by a Novel Protein, P52^rIPK

1998 • 83 citations

Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase.

1994 • 83 citations

The role of the dsRNA-activated kinase, PKR, in signal transduction

1995 • 82 citations

Protein synthesis, cell growth and oncogenesis

1991 • 82 citations

The P58 Cellular Inhibitor Complexes with the Interferon-induced, Double-stranded RNA-dependent Protein Kinase, PKR, to Regulate Its Autophosphorylation and Activity

1996 • 82 citations

Isolation of the Interferon-Inducible RNA-Dependent Protein KinasePkrPromoter and Identification of a Novel DNA Element within the 5′-Flanking Region of Human and MousePkrGenes

1997 • 81 citations

Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKR

1995 • 81 citations

Brain tumors: L-[1-C-11]tyrosine PET for visualization and quantification of protein synthesis rate.

1995 • 81 citations

Ribosome Targeting of PKR Is Mediated by Two Double-stranded RNA-binding Domains and Facilitates in Vivo Phosphorylation of Eukaryotic Initiation Factor-2

1997 • 80 citations

Molecular Mechanisms Responsible for Malignant Transformation by Regulatory and Catalytic Domain Variants of the Interferon-induced Enzyme RNA-dependent Protein Kinase

1995 • 79 citations

The role of eIF4 in cell proliferation.

1996 • 76 citations

Regulation of ornithine decarboxylase in a transformed cell line that overexpresses translation initiation factor eIF-4E.

1996 • 72 citations

Double-stranded (ds) RNA Binding and Not Dimerization Correlates with the Activation of the dsRNA-dependent Protein Kinase (PKR)

1996 • 71 citations

Activation of the Double‐Stranded‐RNA‐Activated Protein Kinase and Induction of Vascular Cell Adhesion Molecule‐1 by Poly (I) · Poly (C) in Endothelial Cells

1995 • 67 citations

Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins

1997 • 67 citations

Expression of the protein kinase PKR in modulated by IRF-1 and is reduced in 5q- associated leukemias.

1996 • 67 citations

Viral evasion of cellular defense mechanisms: regulation of the protein kinase DAI by RNA effectors

1993 • 66 citations

Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2α in transformed cells

1996 • 64 citations

Growth Control of Translation in Mammalian Cells

1995 • 64 citations

Proteins that interact with PKR

1994 • 63 citations

Expression of an elongation factor 1 γ-related sequence in adenocarcinomas of the colon

1992 • 62 citations

Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2α kinase homolog

1998 • 60 citations

The Interferon-Induced Double-Stranded RNA-Activated Human p68 Protein Kinase Potently Inhibits Protein Synthesis in Cultured Cells

1993 • 59 citations

Transformed cells have lost control of ribosome number through their growth cycle

1979 • 58 citations

Homologous Regions of the α Subunit of Eukaryotic Translational Initiation Factor 2 (eIF2α) and the Vaccinia Virus K3L Gene Product Interact with the Same Domain within the dsRNA‐Activated Protein Kinase (PKR)

1997 • 58 citations

Fte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria.

1992 • 56 citations

p53 and translational control

1996 • 55 citations

Detection of protein kinase homologues and viral RNA-binding domains utilizing polyclonal antiserum prepared against a baculovirus-expressed ds RNA-activated 68,000-Da protein kinase

1992 • 53 citations

Use of positron emission tomography in oncology.

1993 • 53 citations

The Kinase Insert Domain of Interferon-induced Protein Kinase PKR Is Required for Activity but Not for Interaction with the Pseudosubstrate K3L

1996 • 51 citations

Endogenous inhibitors of the dsRNA-dependent eIF-2α protein kinase PKR in normal and ras-transformed cells

1994 • 50 citations

Games viruses play: a strategic initiative against the interferon-induced dsRNA activated 68,000 Mr protein kinase

1993 • 50 citations

Protein synthesis rates in colon and liver: stimulation by gastrointestinal pathologies.

1992 • 50 citations

Expression of the Double-Stranded RNA-Dependent Protein Kinase (p68) in Human Breast Tissues

1996 • 49 citations

Abnormal levels and minimal activity of the dsRNA-activated protein kinase, PKR, in breast carcinoma cells

1999 • 48 citations

The Translational Repression Mediated by the Platelet-derived Growth Factor 2/c-sis mRNA Leader Is Relieved during Megakaryocytic Differentiation

1995 • 47 citations

P21 v-ras Inhibits Induction of c-myc and c-fos Expression by Platelet-Derived Growth Factor

1988 • 47 citations

Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts.

1991 • 46 citations

Structural Organization of the Human Gene (PKR) Encoding an Interferon-Inducible RNA-Dependent Protein Kinase (PKR) and Differences from Its Mouse Homolog

1996 • 46 citations

Interferon-induced dsRNA-activated protein kinase (PKR)*: antiproliferative, antiviral and antitumoral functions

1993 • 45 citations

Deregulation of protein synthesis as a mechanism of neoplastic transformation

1996 • 44 citations

The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin κ Gene

1995 • 44 citations

Mechanism of action of a cellular inhibitor of the dsRNA-dependent protein kinase from 3T3-F442A cells.

1992 • 42 citations

Interruption of Myogenesis by Transforming Growth Factor β1 or EGTA Inhibits Expression and Activity of the Myogenic-Associated (2′-5′) Oligoadenylate Synthetase and PKR

1995 • 41 citations

Reversal of the double‐stranded‐RNA‐induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR

1993 • 38 citations

CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.

1992 • 37 citations

Expression of p68 in Human Colon Cancer

1995 • 37 citations

Effect of decreased fte-1 gene expression on protein synthesis, cell growth, and transformation.

1996 • 37 citations

Rapid modulation of the apoptosis regulatory genes, bcl-2 and bax by prolactin in rat Nb2 lymphoma cells

1996 • 37 citations

Overexpression of elongation factor-1? protein in colorectal carcinoma

1998 • 36 citations

Chromosomal Assignment of the Interferon-Inducible Double-Stranded RNA-Dependent Protein Kinase (PRKR) to Human Chromosome 2p21-p22 and Mouse Chromosome 17 E2

1993 • 36 citations

Transcription by RNA polymerases I and III: a potential link between cell growth, protein synthesis and the retinoblastoma protein

1998 • 35 citations

Mutations in the Double-stranded RNA-activated Protein Kinase Insert Region That Uncouple Catalysis from eIF2α Binding

1998 • 32 citations

Use of Vertical Slab Isoelectric Focusing and Immunoblotting to Evaluate Steady-State Phosphorylation of eIF2α in Cultured Cells

1997 • 31 citations

A Eukaryotic Translation Initiation Factor 2-Associated 67 kDa Glycoprotein Partially Reverses Protein Synthesis Inhibition by Activated Double-Stranded RNA-Dependent Protein Kinase in Intact Cells

1996 • 31 citations

Interferon-Responsive Protein Kinase (p68) and Proliferating Cell Nuclear Antigen Are Inversely Distributed in Head and Neck Squamous Cell Carcinoma

1998 • 31 citations

Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA.

1989 • 30 citations

p53-Dependent repression of cdk4 synthesis in transforming growth factor-β-induced G1 cell cycle arrest

1996 • 29 citations

Measurement of tumour protein synthesis in vivo in human colorectal and breast cancer and its variability in separate biopsies from the same tumour

1991 • 28 citations

Elements in the murine c-mos messenger RNA 5'-untranslated region repress translation of downstream coding sequences.

1996 • 28 citations

Co‐ordinated downregulation of bcl‐2 and bax expression during granulocytic and macrophage‐like differentiation of the HL60 promyelocytic leukaemia cell line

1996 • 28 citations

AMPLIFICATION OF TRANSLATIONAL CONTROL BY MEMBRANE‐MEDIATED EVENTS: A PLEIOTROPIC EFFECT ON CELLULAR AND VIRAL GENE EXPRESSION*

1980 • 27 citations

P21 v-ras inhibits induction of c-myc and c-fos expression by platelet-derived growth factor.

1988 • 27 citations

Overexpression of an elongation factor‐1 γ‐hybridizing rna in colorectal adenomas

1993 • 27 citations

Expression of the Double-Stranded RNA-Dependent Protein Kinase (p68) in Squamous Cell Carcinoma of the Head and Neck Region

1993 • 27 citations

Looking beneath the Surface: The Cell Death Pathway of Fas/APO-1 (CD95)

1996 • 26 citations

Role of double-stranded RNA-activated protein kinase in human hematological malignancies.

1997 • 26 citations

Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

1994 • 25 citations

Correlation of the expression of double-stranded RNA-dependent protein kinase (p68) with differentiation in head and neck squamous cell carcinoma

1993 • 21 citations

Cellular Inhibitors of the Interferon-Induced, dsRNA-Activated Protein Kinase

1994 • 21 citations

The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNAdependent, interferon-induced protein kinase, PKR

1993 • 20 citations

Positron Emission Tomography: A new tool for characterization of malignant disease and selection of therapy

1994 • 18 citations

Expression of the protein kinase p-68 recognized by the monoclonal antibody TJ4C4 in human lung neoplasms

1992 • 18 citations

Mapping of the gene for interferon‐inducible dsRNA‐dependent protein kinase to chromosome region 2p21‐22: A site of rearrangements in myeloproliferative disorders

1993 • 17 citations

Inhibitor of Interferon‐Induced Double‐Stranded RNA‐ Dependent Protein Kinase and Its Relevance to Alteration of Cellular Protein Kinase Activity Level in Response to External Stimuli

1991 • 17 citations

Enhancement of the Interferon‐Induced Double‐Stranded RNA‐Dependent Protein Kinase Activity by Sindbis Virus Infection and Heat‐Shock Stress

1990 • 16 citations

Effect of Interferon on Protein Translation during Growth Stages of 3T3 Cells

1996 • 16 citations

Positron emission tomography

1994 • 11 citations

Expression of p68 Protein Kinase as Recognized by the Monoclonal Antibody TJ4C4 during Human Fetal Development

1993 • 9 citations

[Mechanism of the induction of apoptosis by influenza virus infection].

1996 • 7 citations

Induction of interferons and interferon-induced genes

1996 • 5 citations

Induction of interferons and interferon-induced genes

1996 • 3 citations