Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

2001 • 2,623 citations

RNAi

2000 • 2,596 citations

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

2000 • 2,422 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

2000 • 1,767 citations

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

2001 • 1,492 citations

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

1999 • 1,174 citations

Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance

2000 • 1,082 citations

An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus

2000 • 1,061 citations

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

2001 • 1,055 citations

ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway

2001 • 1,008 citations

Gene silencing as an adaptive defence against viruses

2001 • 985 citations

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

2000 • 867 citations

A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans

2001 • 853 citations

Targeted mRNA degradation by double-stranded RNA in vitro

1999 • 845 citations

Post-transcriptional gene silencing by double-stranded RNA

2001 • 833 citations

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways

2000 • 832 citations

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

1997 • 777 citations

RNA silencing as a plant immune system against viruses

2001 • 752 citations

RNA interference—2001

2001 • 698 citations

Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi

2001 • 697 citations

Systemic Spread of Sequence-Specific Transgene RNA Degradation in Plants Is Initiated by Localized Introduction of Ectopic Promoterless DNA

1998 • 694 citations

RNA-triggered gene silencing

1999 • 623 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

2000 • 426 citations

Double-Stranded RNA as a Template for Gene Silencing

2000 • 421 citations

Functional Anatomy of a dsRNA Trigger

2000 • 397 citations

Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems

1999 • 368 citations

Post-transcriptional gene silencing across kingdoms

2000 • 353 citations

RNA Interference and Small Interfering RNAs

2001 • 299 citations

Gene silencing by double-stranded RNA

2001 • 288 citations

Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos

2000 • 239 citations

RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans

2000 • 216 citations

Control of developmental timing in Caenorhabditis elegans

2000 • 152 citations

Inducible expression of double-stranded RNA directs specific genetic interference in Drosophila

2000 • 137 citations

Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target

2000 • 105 citations

SHORT INTEGUMENT (SIN1), a gene required for ovule development in Arabidopsis, also controls flowering time

1996 • 85 citations

Detailed characterization of the posttranscriptional gene-silencing-related small RNA in a GUS gene-silenced tobacco

2000 • 66 citations

Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase

2000 • 45 citations

RNA Interference and Small Interfering RNAs

2001 • 44 citations

Non-coding RNAs: Lightning strikes twice

2000 • 34 citations