Cell Secretion: Current Structural and Biochemical Insights

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

1998 • 2,377 citations

Membrane Fusion: Grappling with SNARE and SM Proteins

2009 • 1,944 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

1992 • 1,274 citations

Membrane Fusion and Exocytosis

1999 • 1,252 citations

The molecular architecture of the nuclear pore complex

2007 • 1,034 citations

Synaptotagmin I functions as a calcium regulator of release probability

2001 • 964 citations

Supramolecular Structure of the Salmonella typhimurium Type III Protein Secretion System

1998 • 872 citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

1988 • 674 citations

Release of secretory products during transient vesicle fusion

1993 • 582 citations

Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins

2007 • 472 citations

Studies on the mechanism of membrane fusion: evidence for an intermembrane calcium(2+) ion-phospholipid complex, synergism with magnesium(2+) ion, and inhibition by spectrin

1979 • 470 citations

A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis

2006 • 454 citations

Identification of a syntaxin-binding site on N-Type calcium channels

1994 • 429 citations

Single synaptic vesicles fusing transiently and successively without loss of identity

2003 • 414 citations

Helical extension of the neuronal SNARE complex into the membrane

2009 • 413 citations

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

1990 • 409 citations

The nuclear pore complex: nucleocytoplasmic transport and beyond

2003 • 408 citations

The architecture of active zone material at the frog's neuromuscular junction

2001 • 383 citations

Reconstitution of Ca ²⁺ -Regulated Membrane Fusion by Synaptotagmin and SNAREs

2004 • 369 citations

A Clamping Mechanism Involved in SNARE-Dependent Exocytosis

2006 • 363 citations

Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells

2003 • 361 citations

Calcium-dependent interaction of N-type calcium channels with the synaptic core complex

1996 • 350 citations

Munc18-1 binds directly to the neuronal SNARE complex

2007 • 346 citations

Transmembrane Segments of Syntaxin Line the Fusion Pore of Ca ² +-Triggered Exocytosis

2004 • 341 citations

Docked granules, the exocytic burst, and the need for ATP hydrolysis in endocrine cells

1995 • 337 citations

Evaluation of the Therapeutic Usefulness of Botulinum Neurotoxin B, C1, E, and F Compared with the Long Lasting Type A

2003 • 330 citations

Three-Dimensional Architecture of Presynaptic Terminal Cytomatrix

2007 • 324 citations

Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.

1995 • 294 citations

The voltage sensitive Lc-type Ca ²⁺ channel is functionally coupled to the exocytotic machinery

1999 • 280 citations

Surface dynamics in living acinar cells imaged by atomic force microscopy: Identification of plasma membrane structures involved in exocytosis

1997 • 272 citations

Goblet Cells Secretion and Mucogenesis

1990 • 271 citations

Calcium/magnesium specificity in membrane fusion: kinetics of aggregation and fusion of phosphatidylserine vesicles and the role of bilayer curvature

1981 • 252 citations

The aquaporin family of molecular water channels.

1994 • 216 citations

Sly1 Binds to Golgi and ER Syntaxins via a Conserved N-Terminal Peptide Motif

2002 • 213 citations

Structural Evidence for Common Ancestry of the Nuclear Pore Complex and Vesicle Coats

2008 • 213 citations

How Tlg2p/syntaxin 16 'snares' Vps45

2002 • 206 citations

Ultrastructural Organization of Bovine Chromaffin Cell Cortex—Analysis by Cryofixation and Morphometry of Aspects Pertinent to Exocytosis

1997 • 198 citations

On the mechanism of G protein beta gamma subunit activation of the muscarinic K+ channel in guinea pig atrial cell membrane. Comparison with the ATP-sensitive K+ channel.

1992 • 195 citations

Secretin Promotes Osmotic Water Transport in Rat Cholangiocytes by Increasing Aquaporin-1 Water Channels in Plasma Membrane

1997 • 187 citations

Motors and membrane traffic

1997 • 187 citations

Frequency-Dependent Kinetics and Prevalence of Kiss-and-Run and Reuse at Hippocampal Synapses Studied with Novel Quenching Methods

2006 • 169 citations

Disruption of Pancreatic β-Cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis

2004 • 166 citations

Imaging single membrane fusion events mediated by SNARE proteins

2004 • 164 citations

Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles

2002 • 158 citations

Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusion.

1995 • 150 citations

Control of mucus hydration as a Donnan equilibrium process

1981 • 145 citations

Functional and physical coupling of voltage‐sensitive calcium channels with exocytotic proteins: ramifications for the secretion mechanism

2001 • 140 citations

Role of Lipid Microdomains in P/Q-type Calcium Channel (Cav2.1) Clustering and Function in Presynaptic Membranes

2004 • 138 citations

Syntaxin 1 interacts with the L _D subtype of voltage-gated Ca ²⁺ channels in pancreatic β cells

1999 • 138 citations

Secretory traffic in the eukaryotic parasite Toxoplasma gondii

2002 • 138 citations

Selective nucleotide-release from dense-core granules in insulin-secreting cells

2005 • 136 citations

Molecular Mechanism of Mucin Secretion: I. The Role of Intragranular Charge Shielding

1987 • 136 citations

Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity

2004 • 134 citations

Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells.

1995 • 134 citations

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic β cells

2006 • 132 citations

Structure and Composition of the Fusion Pore

2003 • 129 citations

Inhibition of Cholesterol Biosynthesis Impairs Insulin Secretion and Voltage-Gated Calcium Channel Function in Pancreatic β-Cells

2008 • 126 citations

“Kiss-and-Run” Glutamate Secretion in Cultured and Freshly Isolated Rat Hippocampal Astrocytes

2005 • 126 citations

Zones of exocytotic release on bovine adrenal medullary cells in culture.

1994 • 125 citations

The Secretory Granule Matrix: A Fast-Acting Smart Polymer

1993 • 125 citations

Compound vesicle fusion increases quantal size and potentiates synaptic transmission

2009 • 123 citations

Exocytosis in chromaffin cells. Possible involvement of the heterotrimeric GTP-binding protein G(o)

1993 • 122 citations

G _i regulation of secretory vesicle swelling examined by atomic force microscopy

1997 • 117 citations

Structure and Dynamics of the Fusion Pores in Live GH-Secreting Cells Revealed Using Atomic Force Microscopy

2002 • 117 citations

Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha 1A subunit of the P/Q-type calcium channel

1997 • 116 citations

Reconstituted Fusion Pore

2003 • 115 citations

SNAREs in Opposing Bilayers Interact in a Circular Array to Form Conducting Pores

2002 • 114 citations

The Heterotrimeric G-protein Gi Is Localized to the Insulin Secretory Granules of β-Cells and Is Involved in Insulin Exocytosis

1995 • 113 citations

A Gain-of-Function Mutation in Synaptotagmin-1 Reveals a Critical Role of Ca²⁺-Dependent SolubleN-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Binding in Synaptic Exocytosis

2006 • 113 citations

Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation

2009 • 110 citations

Evidence That Vesicles Undergo Compound Fusion on the Synaptic Ribbon

2008 • 110 citations

STRUCTURE AND DYNAMICS OF THE FUSION PORE IN LIVE CELLS

2002 • 105 citations

Irreversible swelling of secretory granules during exocytosis caused by calcium

1985 • 103 citations

The surface-connected canalicular system of blood platelets--a fenestrated membrane system.

1980 • 101 citations

Calcium drives fusion of SNARE‐apposed bilayers

2003 • 100 citations

Structure, isolation, composition and reconstitution of the neuronal fusion pore

2004 • 98 citations

Myosin-Va Regulates Exocytosis through the Submicromolar Ca²+-dependent Binding of Syntaxin-1A

2005 • 98 citations

Reversible condensation of mast cell secretory products in vitro

1991 • 98 citations

Vesicle swelling regulates content expulsion during secretion

2004 • 89 citations

Is swelling of the secretory granule matrix the force that dilates the exocytotic fusion pore?

1991 • 89 citations

Is Assembly of the SNARE Complex Enough to Fuel Membrane Fusion?

2009 • 87 citations

Involvement of Water Channels in Synaptic Vesicle Swelling

2005 • 84 citations

Regulation of the water channel aquaporin‐1: isolation and reconstitution of the regulatory complex

2003 • 82 citations

Molecular mechanism of product storage and release in mucin secretion. II. The role of extracellular Ca++

1987 • 82 citations

New Structure Involved in Transient Membrane Fusion and Exocytosis

2002 • 80 citations

Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol

2008 • 79 citations

Size of Supramolecular SNARE Complex: Membrane-Directed Self-Assembly

2005 • 78 citations

Globular Tail of Myosin-V Is Bound to VAMP/Synaptobrevin

2001 • 75 citations

Anti-immunoglobulin-induced histamine secretion by rat peritoneal mast cells studied by immunoferritin electron microscopy.

1975 • 72 citations

Ionic control of the size of the vesicle matrix of beige mouse mast cells.

1991 • 72 citations

Dynamic Regulation of the Large Exocytotic Fusion Pore in Pancreatic Acinar Cells

2007 • 71 citations

Structure and dynamics of dimyristoylphosphatidic acid/calcium complexes by deuterium NMR, infrared, and Raman spectroscopies and small-angle x-ray diffraction

1991 • 68 citations

Regulated spacing of synapses and presynaptic active zones at larval neuromuscular junctions in different genotypes of the fliesDrosophila andSarcophaga

1998 • 64 citations

Energy-Dependent Disassembly of Self-Assembled SNARE Complex: Observation at Nanometer Resolution Using Atomic Force Microscopy

2005 • 59 citations

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells

2008 • 56 citations

Targeting of Voltage-Gated K⁺and Ca²⁺Channels and SolubleN-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Proteins to Cholesterol-Rich Lipid Rafts in Pancreatic α-Cells: Effects on Glucagon Stimulus-Secretion Coupling

2007 • 51 citations

Imaging single synaptic vesicles undergoing repeated fusion events: kissing, running, and kissing again

2003 • 51 citations

Interaction of Syntaxin with α-Fodrin, a Major Component of the Submembranous Cytoskeleton

2001 • 50 citations

GTP-binding proteins inhibit cAMP activation of chloride channels in cystic fibrosis airway epithelial cells.

1992 • 50 citations

Membrane behavior of exocytic vesicles: II in fate of the trichocyst membranes in paramecium after induced trichocyst discharge

1976 • 49 citations

ATP sensitive K+ conductance in pancreatic zymogen granules: Block by glyburide and activation by diazoxide

1992 • 48 citations

Influence of Cholesterol on Catecholamine Release from the Fusion Pore of Large Dense Core Chromaffin Granules

2010 • 47 citations

THE NUMBER OF SECRETORY VESICLES REMAINS UNCHANGED FOLLOWING EXOCYTOSIS

2002 • 46 citations

Insulin secretion by ‘kiss-and-run’ exocytosis in clonal pancreatic islet β-cells

2003 • 44 citations

Synthesis and Secretion of Hemoglobin by Retinal Pigment Epithelium

2009 • 44 citations

The Four-helix Bundle of the Neuronal Target Membrane SNARE Complex Is Neither Disordered in the Middle nor Uncoiled at the C-terminal Region

2002 • 43 citations

Secretagogue and second messenger-activated Cl? permeabilities in isolated pancreatic zymogen granules

1989 • 43 citations

EM 3D contour maps provide protein assembly at the nanoscale within the neuronal porosome complex

2008 • 43 citations

Ca²⁺–dimethylphosphate complex formation: Providing insight into Ca²⁺‐mediated local dehydration and membrane fusion in cells

2008 • 42 citations

Membrane behavior of exocytic vesicles

1976 • 41 citations

Membrane Dynamics of the Water Transport Protein Aquaporin-1 in Intact Human Red Cells

1999 • 41 citations

Ionic and osmotic dependence of secretion from permeabilised acini of the rat pancreas

1989 • 41 citations

Direct interaction between SNAP-23 and L-type Ca²⁺channel

2005 • 38 citations

Secretagogues activate chloride transport pathways in pancreatic zymogen granules

1988 • 37 citations

Stabilization and swelling of hagfish slime mucin vesicles

2010 • 36 citations

Fusion Step-Specific Influence of Cholesterol on SNARE-Mediated Membrane Fusion

2009 • 36 citations

Involvement of vH⁺‐ATPase in synaptic vesicle swelling

2009 • 35 citations

Porosome in astrocytes

2008 • 31 citations

Membrane Lipids Influence Protein Complex Assembly−Disassembly

2010 • 30 citations

Dual modulation of chloride conductance by nucleotides in pancreatic and parotid zymogen granules

1990 • 30 citations

Circular dichroism (CD) spectroscopy of the assembly and disassembly of SNAREs: The proteins involved in membrane fusion in cells

2008 • 29 citations

Structure of membrane‐associated neuronal SNARE complex: implication in neurotransmitter release

2009 • 28 citations

Structure and Dynamics of the Fusion Pores in Live GH-Secreting Cells Revealed Using Atomic Force Microscopy

2002 • 26 citations

Molecular mechanism of product storage and release in mucin secretion

1986 • 26 citations

Chloride transport across the membrane of parotid secretory granules

1990 • 25 citations

Goblet Cells Secretion And Mucogenesis

1990 • 25 citations

Cholesterol is critical to the integrity of neuronal porosome/fusion pore

2006 • 24 citations

AQPs and Control of Vesicle Volume in Secretory Cells

2006 • 23 citations

Cell Membrane Structures during Exocytosis

2007 • 21 citations

Release of secretory products during transient vesicle fusion

1993 • 20 citations

Effects of cholecystokinin, cholecystokinin JMV‐180 and GTP analogs on enzyme secretion from permeabilized acini and chloride conductance in isolated zymogen granules of the rat pancreas

1991 • 19 citations

Compound Exocytosis in Pituitary Cells

2009 • 17 citations

A preferential pole for exocytosis in cultured chromaffin cells revealed by confocal microscopy

1999 • 16 citations

Granule swelling in stimulated bovine adrenal chromaffin cells: Regulation by internal granule pH

1995 • 15 citations

Cell secretion: an update

2008 • 14 citations

Secretory vesicles transiently dock and fuse at the porosome to discharge contents during cell secretion

2010 • 14 citations

Platelet Secretory Process

1999 • 13 citations

Co-transfection of EYFP-GH and ECFP-rab3B in an experimental pituitary GH3 cell: a role of rab3B in secretion of GH through porosome.

2009 • 12 citations

Cell Secretion: Current Structural and Biochemical Insights

2010 • 11 citations

Platelet Secretory Process

1999 • 10 citations

Effects of valinomycin on osmotic lysis of zymogen granules and amylase exocytosis from parotid acini

1993 • 8 citations

Zones of exocytotic release on bovine adrenal medullary cells in culture

1994 • 6 citations

Swelling of the vesicle is prerequisite for PTH secretion

1996 • 5 citations

Co-transfection of EYFP-GH and ECFP-rab3B in an experimental pituitary GH3 cell: a role of rab3B in secretion of GH through porosome.

2009 • 4 citations

Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells.

1995 • 3 citations

Granule swelling in stimulated bovine adrenal chromaffin cells: regulation by internal granule pH

1994 • 1 citations

Deleted Work

1955 • 0 citations