Functional and physical coupling of voltage‐sensitive calcium channels with exocytotic proteins: ramifications for the secretion mechanism

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

1998 • 2,377 citations

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

1973 • 2,122 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Co‐operative action of calcium ions in transmitter release at the neuromuscular junction

1967 • 1,326 citations

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

1992 • 1,274 citations

Primary structure and functional expression from complementary DNA of a brain calcium channel

1991 • 871 citations

Microdomains of High Calcium Concentration in a Presynaptic Terminal

1992 • 837 citations

C2-domains, Structure and Function of a Universal Ca2+-binding Domain

1998 • 835 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

Intracellular calcium dependence of transmitter release rates at a fast central synapse

2000 • 773 citations

The syntaxin family of vesicular transport receptors

1993 • 656 citations

Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse

1991 • 638 citations

Specificity and regulation of a synaptic vesicle docking complex

1994 • 601 citations

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

1995 • 597 citations

Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin.

1993 • 540 citations

Calcium Sensitivity of Glutamate Release in a Calyx-Type Terminal

2000 • 511 citations

The synaptic SNARE complex is a parallel four-stranded helical bundle

1998 • 497 citations

Transport, capture and exocytosis of single synaptic vesicles at active zones

2000 • 464 citations

Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses

1999 • 438 citations

Identification of a syntaxin-binding site on N-Type calcium channels

1994 • 429 citations

SNARE Complex Formation Is Triggered by Ca 2+ and Drives Membrane Fusion

1999 • 415 citations

Functional impact of syntaxin on gating of N-type and Q-type calcium channels

1995 • 414 citations

Neurotransmitter release — four years of SNARE complexes

1997 • 400 citations

Syntaxin and synaptobrevin function downstream of vesicle docking in drosophila

1995 • 389 citations

Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release

1998 • 388 citations

Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1

1995 • 372 citations

Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function

1998 • 366 citations

Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS

1991 • 366 citations

Structural Organization of the Synaptic Exocytosis Core Complex

1997 • 352 citations

Calcium-dependent interaction of N-type calcium channels with the synaptic core complex

1996 • 350 citations

Defining the functions of trans-SNARE pairs

1998 • 343 citations

SNARE Interactions Are Not Selective

1999 • 322 citations

Genetic and electrophysiological studies of drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission

1995 • 321 citations

Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25.

1996 • 321 citations

Primary structure of a calcium channel that is highly expressed in the rat cerebellum.

1991 • 309 citations

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

1997 • 309 citations

Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release

1999 • 296 citations

Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.

1995 • 294 citations

Inhibition of Neurotransmission by Peptides Containing the Synaptic Protein Interaction Site of N-Type Ca2+ Channels

1996 • 290 citations

SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils.

1994 • 288 citations

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants.

1994 • 286 citations

Ca2+-Dependent Exocytosis in the Somata of Dorsal Root Ganglion Neurons

1996 • 285 citations

The voltage sensitive Lc-type Ca ²⁺ channel is functionally coupled to the exocytotic machinery

1999 • 280 citations

Kinetics of Synaptotagmin Responses to Ca2+ and Assembly with the Core SNARE Complex onto Membranes

1999 • 277 citations

Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1.

1992 • 276 citations

Identification of a Minimal Core of the Synaptic SNARE Complex Sufficient for Reversible Assembly and Disassembly

1998 • 276 citations

Mechanisms Underlying Phasic and Sustained Secretion in Chromaffin Cells from Mouse Adrenal Slices

1999 • 276 citations

HPC-1 is associated with synaptotagmin and omega-conotoxin receptor.

1992 • 275 citations

Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels.

1996 • 273 citations

Botulinum Neurotoxin Type C Cleaves a Single Lys-Ala Bond within the Carboxyl-terminal Region of Syntaxins

1995 • 272 citations

Single calcium channels and acetylcholine release at a presynaptic nerve terminal

1993 • 266 citations

Three types of Ca2+ channel trigger secretion with different efficacies in chromaffin cells

1994 • 263 citations

Rapid and efficient fusion of phospholipid vesicles by the α-helical core of a SNARE complex in the absence of an N-terminal regulatory domain

1999 • 259 citations

Ultrafast Exocytosis Elicited by Calcium Current in Synaptic Terminals of Retinal Bipolar Neurons

1996 • 259 citations

The calcium channel and the organization of the presynaptic transmitter release face

1997 • 242 citations

TheCaenorhabditis elegans unc-64Locus Encodes a Syntaxin That Interacts Genetically with Synaptobrevin

1998 • 223 citations

Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms

1997 • 219 citations

A Structural Change Occurs upon Binding of Syntaxin to SNAP-25

1997 • 214 citations

Purification of the N-type calcium channel associated with syntaxin and synaptotagmin. A complex implicated in synaptic vesicle exocytosis.

1994 • 210 citations

Syntaxin 1A Interacts with Multiple Exocytic Proteins to Regulate Neurotransmitter Release In Vivo

1999 • 204 citations

Molecular determinants of Ca2+ channel function and drug action

1995 • 198 citations

ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner

1998 • 194 citations

Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs

1999 • 189 citations

Alteration of Ca²⁺Dependence of Neurotransmitter Release by Disruption of Ca²⁺Channel/Syntaxin Interaction

1997 • 183 citations

Effect of changes in action potential shape on calcium currents and transmitter release in a calyx–type synapse of the rat auditory brainstem

1999 • 180 citations

Morphologically Docked Synaptic Vesicles Are Reduced insynaptotagminMutants ofDrosophila

1998 • 179 citations

Interaction of the synprint site of N-type Ca ²⁺ channels with the C2B domain of synaptotagmin I

1997 • 178 citations

α-Latrotoxin Receptor CIRL/Latrophilin 1 (CL1) Defines an Unusual Family of Ubiquitous G-protein-linked Receptors

1998 • 178 citations

Crystal Structure of the Cytosolic C2a-C2b Domains of Synaptotagmin III

1999 • 174 citations

Reciprocal regulation of P/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin

1999 • 168 citations

Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A

2000 • 160 citations

Localization of synaptotagmin-binding domains on syntaxin

1996 • 158 citations

Phosphorylation of the Synaptic Protein Interaction Site on N-type Calcium Channels Inhibits Interactions with SNARE Proteins

1997 • 154 citations

Rapid Exocytosis in Single Chromaffin Cells Recorded from Mouse Adrenal Slices

1997 • 147 citations

On the structure of the ‘synaptosecretosome’ Evidence for a neurexin/synaptotagmin/syntaxin/Ca²⁺channel complex

1993 • 144 citations

Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal.

1995 • 144 citations

Biochemical and Functional Studies of Cortical Vesicle Fusion: The SNARE Complex and Ca2+ Sensitivity

1998 • 139 citations

Syntaxin 1 interacts with the L _D subtype of voltage-gated Ca ²⁺ channels in pancreatic β cells

1999 • 138 citations

Interaction of SNARE Complexes with P/Q-type Calcium Channels in Rat Cerebellar Synaptosomes

1996 • 138 citations

Vesicular Quantal Size Measured by Amperometry at Chromaffin, Mast, Pheochromocytoma, and Pancreatic β‐Cells

1996 • 134 citations

Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells.

1995 • 134 citations

Protease Resistance of Syntaxin·SNAP-25·VAMP Complexes

1998 • 125 citations

Zones of exocytotic release on bovine adrenal medullary cells in culture.

1994 • 125 citations

Ca ²⁺ -dependent and -independent interactions of the isoforms of the α _1A subunit of brain Ca ²⁺ channels with presynaptic SNARE proteins

1997 • 122 citations

Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha 1A subunit of the P/Q-type calcium channel

1997 • 116 citations

Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion

1997 • 103 citations

Calcium sensors in regulated exocytosis

1998 • 96 citations

Calcium Can Disrupt the SNARE Protein Complex on Sea Urchin Egg Secretory Vesicles without Irreversibly Blocking Fusion

1998 • 90 citations

A stable interaction between syntaxin 1a and synaptobrevin 2 mediated by their transmembrane domains

1999 • 89 citations

Targeting of SNAP-25 to Membranes Is Mediated by Its Association with the Target SNARE Syntaxin

2000 • 83 citations

Recent Advances in the Molecular Understanding of Voltage-Gated Ca2+ Channels

1999 • 82 citations

Characterization of the interactions between the glycine transporters GLYT1 and GLYT2 and the SNARE protein syntaxin 1A

2000 • 79 citations

Synaptotagmin restores kinetic properties of a syntaxin‐associated N‐type voltage sensitive calcium channel

1997 • 78 citations

SNAREs and regulated vesicle exocytosis

1997 • 74 citations

Ca(2+)-dependent conformational change in synaptotagmin I.

1994 • 74 citations

Regulation of the Amiloride-sensitive Epithelial Sodium Channel by Syntaxin 1A

1999 • 72 citations

A Neuronal Sec1 Homolog Regulates Neurotransmitter Release at the Squid Giant Synapse

1998 • 69 citations

Timing of Dense-Core Vesicle Exocytosis Depends on the Facilitation L-Type Ca Channel in Adrenal Chromaffin Cells

1998 • 65 citations

Interaction of Syntaxins with the Amiloride-sensitive Epithelial Sodium Channel

1999 • 64 citations

Ca2+ and the regulation of neurotransmitter secretion

1997 • 62 citations

Two components of transmitter release in retinal bipolar cells: exocytosis and mobilization of synaptic vesicles

1997 • 58 citations

Synaptic vesicle docking and fusion

1999 • 56 citations

Block of transmitter release by botulinum C1 action on syntaxin at the squid giant synapse

1997 • 55 citations

Exocytosis in adrenal chromaffin cells.

1993 • 51 citations

The Probability of Quantal Secretion Near a Single Calcium Channel of an Active Zone

2000 • 50 citations

N-type voltage-sensitive calcium channel interacts with syntaxin, synaptotagmin and SNAP-25 in a multiprotein complex.

1998 • 49 citations

Calcium transients and neurotransmitter release at an identified synapse

1999 • 45 citations

RECONSTITUTION OF REGULATED EXOCYTOSIS IN CELL-FREE SYSTEMS: A Critical Appraisal

1999 • 43 citations

Probabilistic secretion of quanta and the synaptosecretosome hypothesis: evoked release at active zones of varicosities, boutons, and endplates

1997 • 42 citations

Functional Analysis of the C2A Domain of Synaptotagmin 1: Implications for Calcium-Regulated Secretion

1998 • 39 citations

Monoclonal antibodies immunoprecipitating ω-conotoxin-sensitive calcium channel molecules recognize two novel proteins localized in the nervous system

1991 • 34 citations

Simultaneous Measurement of Evoked Release and [Ca²⁺]_iin a Crayfish Release Bouton Reveals High Affinity of Release to Ca²⁺

1999 • 33 citations

Specialized release zones in chromaffin cells examined with pulsed-laser imaging

1996 • 31 citations

nSec-1 (munc-18) interacts with both primed and unprimed syntaxin 1A and associates in a dimeric complex on adrenal chromaffin granules

1999 • 27 citations

<b>SYNAPTOCANALIN I, A PROTEIN ASSOCIATED WITH BRAIN ω-CONOTOXIN-SENSITIVE CALCIUM CHANNELS </b>

1992 • 25 citations

Vesicle-Associated Proteins and Quantal Release at Single Active Zones of Amphibian (Bufo marinus) Motor-Nerve Terminals

1999 • 24 citations

A preferential pole for exocytosis in cultured chromaffin cells revealed by confocal microscopy

1999 • 16 citations

HPC-1/Syntaxin 1A Suppresses Exocytosis of PC12 Cells

1999 • 14 citations

nSec-1 (munc-18) interacts with both primed and unprimed syntaxin 1A and associates in a dimeric complex on adrenal chromaffin granules

1999 • 13 citations

A Cell-Free System for Ca2+-Regulated Exocytosis

1998 • 10 citations

Do caged-Ca2+ compounds mimic the physiological stimulus for secretion?

1995 • 9 citations

The voltage sensitive Lc-type Ca 21 channel is functionally coupled to the exocytotic machinery (exocytosisyb-cellsysynaptotagminysyntaxinycapacitance)

1999 • 2 citations