Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Clinical staging of chronic lymphocytic leukemia

1975 • 2,706 citations

Germinal Centers

1994 • 1,680 citations

The LY‐1B Cell Lineage

1986 • 603 citations

Progenitors for Ly-1 B cells are distinct from progenitors for other B cells.

1985 • 599 citations

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1981 • 509 citations

The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1994 • 390 citations

Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes.

1991 • 364 citations

Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.

1984 • 344 citations

B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL

1991 • 298 citations

Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.

1993 • 298 citations

Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia.

1989 • 290 citations

Residues that mediate DNA binding of autoimmune antibodies.

1993 • 268 citations

Clonal evolution of a follicular lymphoma: evidence for antigen selection.

1992 • 255 citations

Small rearrangements in structures of Fv and Fab fragments of antibody D 1.3 on antigen binding

1990 • 247 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies

1990 • 222 citations

T Cell Helper Defect in Patients with Chronic Lymphocytic Leukemia

1979 • 197 citations

Chronic lymphocytic leukemic (CLL) cells secrete multispecific autoantibodies

1988 • 179 citations

Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes.

1978 • 173 citations

Evolutionary nucleotide replacements in DNA

1979 • 169 citations

B-1 cells are made, not born

1993 • 141 citations

Immunoglobulin gene ‘fingerprinting’: an approach to analysis of B lymphoid clonality in lymphoproliferative disorders

1991 • 135 citations

Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors.

1993 • 129 citations

Polymemse Chain Reaction Using Mixed Primers: Cloning of Human Monoclonal Antibody Variable Region Genes from Single Hybridoma Cells

1989 • 123 citations

IgG subclass expression by human B lymphocytes and plasma cells: B lymphocytes precommitted to IgG subclass can be preferentially induced by polyclonal mitogens with T cell help.

1983 • 118 citations

CLASS, SUBCLASS, AND ALLELIC EXCLUSION OF MEMBRANE-BOUND Ig OF HUMAN B LYMPHOCYTES

1972 • 100 citations

High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia.

1987 • 99 citations

The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.

1991 • 91 citations

CD5 and immunoglobulin V gene expression in B-cell lymphomas and chronic lymphocytic leukemia

1990 • 87 citations

A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma.

1994 • 67 citations

Structural Patterns in Anti-DNA Antibodies from MRL/lpr Mice

1989 • 65 citations

The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis

1992 • 61 citations

Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia.

1992 • 60 citations

V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytic leukemia and displaying autoantibody activity

1993 • 60 citations

Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen.

1992 • 58 citations

Structure of the V_H and V_L segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli β-galactosidase

1993 • 58 citations

自己免疫疾患に関与するLy-1B細胞の分化

1986 • 57 citations

Intraclonal diversity in the VH genes expressed by CD5- chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor.

1990 • 57 citations

Idiotypic analysis of myeloma proteins: anti-DNA activity of monoclonal immunoglobulins bearing an SLE idiotype is more common in IgG than IgM antibodies.

1987 • 56 citations

An apparently common mechanism of generating antibody diversity: Length variation of the VL-JL junction

1994 • 51 citations

A cross-reactive idiotype on anti-DNA antibodies defines a H chain determinant present almost exclusively on IgG antibodies.

1989 • 49 citations

Differential usage of an Ig heavy chain variable region gene by human B- cell tumors

1993 • 49 citations

Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia.

1993 • 47 citations

Surface Markers, Heavy Chain Sequences and B Cell Lineages

1992 • 40 citations

Expression of CD5 and CD38 by human CD5⁻ B cells: Requirement for special stimuli

1994 • 39 citations

Immunoglobulin genes in chronic lymphocytic leukemia.

1993 • 39 citations

Polymorphism of the human Ig VH4 gene family.

1991 • 37 citations

Expression of members of the immunoglobulin V_H3 gene families is not restricted at the level of individual genes in human chronic lymphocytic leukemia

1992 • 37 citations

Evidence for differential responsiveness of human CD5⁺ and CD5⁻ B cell subsets to T cell‐independent mitogens

1991 • 36 citations

The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes.

1993 • 28 citations

Biased Usage of Variable and Constant‐Region Ig Genes by IgG⁺, CD5⁺ Human Leukemic B Cells^a

1992 • 21 citations

IgG⁺, CD5⁺Human Chronic Lymphocytic Leukemia B Cells. Production of IgG Antibodies That Exhibit Diminished Autoreactivity and IgG Subclass Skewing

1994 • 19 citations

Vχ gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the Vχ locus and do not show somatic mutation

1993 • 16 citations

SAW: a graphical user interface for the analysis of immunoglobulin variable domain sequences.

1993 • 11 citations